Angela Corvino

All Publications

• PATHY-inspired partial tumor irradiation on a small-animal irradiator: workflow development and first therapeutic evaluation in glioma PHYSICS IN MEDICINE AND BIOLOGY Corvino, A., Juchaux, M., Gilbert, C., Espenon, J., Sebrie, C., Tubin, S., Prezado, Y. 2026; 71 (13)

  Abstract

  Objective. Partial tumor irradiation (PTI) targeting hypoxic/hypovascularized/hypometabolic tumor segment (PATHY) while sparing the peritumoral immune microenvironment has emerged as an innovative radiotherapy (RT) strategy designed to exploit non-targeted and immune-mediated effects. Although promising clinical responses have been reported, the limited availability and technical complexity of preclinical PATHY implementations have constrained mechanistic investigation and rational optimization of treatment parameters. Here, we establish a PATHY-inspired PTI workflow on a Small Animal Radiation Research Platform and evaluate its therapeutic efficacy in a rat glioma model.Approach.A protocol was developed integrating magnetic resonance imaging-based target delineation, millimetric small-field dosimetry, andin vivoquality assurance to selectively irradiate the tumor core using orthovoltage photons. Tumor-bearing rats were assigned to one of three PTI regimens differing in temporal fractionation-conventional fractionation (15 Gy × 3, Δt= 24 h), accelerated fractionation (15 Gy × 3, Δt= 8 h), or single-fraction PTI (30 Gy × 1)-or to a non-irradiated control group.Main results.All PTI regimens significantly prolonged overall survival compared with controls, yielding median survival increases ranging from 32% to 62%. No statistically significant differences were observed among the irradiated groups, indicating that, under the investigated dose and fractionation conditions, interfraction timing did not significantly influence survival outcome in this highly radioresistant and immunosuppressive glioma model.Significance.This study establishes a robust and reproducible preclinical framework for PTI and provides the firstin vivoevidence of its therapeutic potential in glioma. By enabling systematic investigation of partial tumor high-dose irradiation, this platform lays the groundwork for future studies incorporating hypoxia-guided targeting and immune mechanistic endpoints to refine and translate PATHY-based RT strategies.

  View details for DOI 10.1088/1361-6560/ae7232

  View details for Web of Science ID 001808886300001

  View details for PubMedID 42173137

• Monte Carlo-based characterization of proton minibeam radiation therapy across clinically relevant beam parameters PHYSICS & IMAGING IN RADIATION ONCOLOGY Corvino, A., Schneider, T., Prezado, Y. 2026; 40

  View details for DOI 10.1016/j.phro.2026.101032

  View details for Web of Science ID 001846327200001

• On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Prezado, Y., Lamirault, C., Larcher, T., Gilbert, C., Espenon, J., Patriarca, A., de Marzi, L., Corvino, A., Ortiz, R., Juchaux, M. 2025; 205: 110769

  Abstract

  Spatially fractionated radiotherapy is an unconventional radiotherapy approach able to widen the therapeutic window for difficult-to-treat cases today. To unlock its full potential, accurate knowledge of the relationship between the different dosimetry and geometry parameters and the biological response is still needed. When the same beam width is used, the valley dose has been assumed to be the main parameter influencing normal tissue sparing, with peak doses having little relevance. However, a recent retrospective evaluation of preclinical data suggests peak dose plays a major role in the normal tissue sparing of minibeam radiation therapy (MBRT). The goal of this study was to experimentally validate for the first time the significance of the peak dose for normal tissue sparing in proton MBRT.We irradiated the brains of naive rats with two different configurations of pMBRT, resulting in the same valley and average doses but different peak doses. Behavioural tests and histopathological evaluations were carried out.At the same valley dose, a higher peak dose (high peak-to-valley dose ratio (PVDR), larger centre-to-centre (ctc) distance) is more detrimental than a lower peak dose (low PVDR, narrower catch). In the first case, the animals exhibited some hyperactivity in locomotor and exploration activity as well as memory alterations. In addition, the highest peak dose led to a significantly higher cumulative lesion score in the histopathology evaluations than the lowest peak dose.While our study does not exclude the relevant role of the valley dose in tissue sparing, it does highlight the importance of peak doses, contradicting previous assumptions. Our results agree with the conclusion of a recent retrospective evaluation of preclinical studies in micro and minibeam radiation therapy.

  View details for DOI 10.1016/j.radonc.2025.110769

  View details for PubMedID 39947329

• PMC11972043 Photon mini-GRID therapy for preoperative breast cancer tumor treatment: A treatment plan study Corvino, A. 2025

  View details for DOI 10.1002/mp.17634

• β-delayed multiple-particle emitters minibeam radiation therapy: first dosimetric evaluation with Monte Carlo simulations FRONTIERS IN PHYSICS Corvino, A., Schneider, T., Prezado, Y. 2024; 12

  View details for DOI 10.3389/fphy.2024.1390439

  View details for Web of Science ID 001217152600001

• miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches HIGH POWER LASER SCIENCE AND ENGINEERING Corvino, A., Reimold, M., Beyreuther, E., Brack, F., Kroll, F., Pawelke, J., Schilz, J. D., Schneider, M., Schramm, U., Umlandt, M. P., Zeil, K., Ziegler, T., Metzkes-Ng, J. 2024; 12

  View details for DOI 10.1017/hpl.2024.1

  View details for Web of Science ID 001196941600001