Professional Education

  • Bsc, Pisa University, Physics (2019)
  • Msc, Pisa University, Medical Physics (2022)
  • PhD, Paris Saclay University, Medical Physics (2025)

Stanford Advisors

Contact

  • Academic
    acorvino@stanford.edu
    University - Scholar Department: Surgery Position: Postdoctoral Scholar

Additional Info

Current Research and Scholarly Interests

Postdoctoral researcher pioneering the advancement of novel radiotherapy approaches (FLASH, SFRT) to tackle a critical challenge: minimising damage to healthy tissue surrounding difficult to treat tumors. I'm hands-on in all stages of preclinical experimentation, spanning from Monte Carlo simulations for planning and precise dosimetry, to conducting small animal irradiation, follow-ups, and insightful data analysis.

All Publications

  • PATHY-inspired partial tumor irradiation on a small-animal irradiator: workflow development and first therapeutic evaluation in glioma PHYSICS IN MEDICINE AND BIOLOGY Corvino, A., Juchaux, M., Gilbert, C., Espenon, J., Sebrie, C., Tubin, S., Prezado, Y. 2026; 71 (13)

    Abstract

    Objective. Partial tumor irradiation (PTI) targeting hypoxic/hypovascularized/hypometabolic tumor segment (PATHY) while sparing the peritumoral immune microenvironment has emerged as an innovative radiotherapy (RT) strategy designed to exploit non-targeted and immune-mediated effects. Although promising clinical responses have been reported, the limited availability and technical complexity of preclinical PATHY implementations have constrained mechanistic investigation and rational optimization of treatment parameters. Here, we establish a PATHY-inspired PTI workflow on a Small Animal Radiation Research Platform and evaluate its therapeutic efficacy in a rat glioma model.Approach.A protocol was developed integrating magnetic resonance imaging-based target delineation, millimetric small-field dosimetry, andin vivoquality assurance to selectively irradiate the tumor core using orthovoltage photons. Tumor-bearing rats were assigned to one of three PTI regimens differing in temporal fractionation-conventional fractionation (15 Gy × 3, Δt= 24 h), accelerated fractionation (15 Gy × 3, Δt= 8 h), or single-fraction PTI (30 Gy × 1)-or to a non-irradiated control group.Main results.All PTI regimens significantly prolonged overall survival compared with controls, yielding median survival increases ranging from 32% to 62%. No statistically significant differences were observed among the irradiated groups, indicating that, under the investigated dose and fractionation conditions, interfraction timing did not significantly influence survival outcome in this highly radioresistant and immunosuppressive glioma model.Significance.This study establishes a robust and reproducible preclinical framework for PTI and provides the firstin vivoevidence of its therapeutic potential in glioma. By enabling systematic investigation of partial tumor high-dose irradiation, this platform lays the groundwork for future studies incorporating hypoxia-guided targeting and immune mechanistic endpoints to refine and translate PATHY-based RT strategies.

    View details for DOI 10.1088/1361-6560/ae7232

    View details for Web of Science ID 001808886300001

    View details for PubMedID 42173137

  • PMC11972043 Photon mini-GRID therapy for preoperative breast cancer tumor treatment: A treatment plan study Corvino, A. 2025

    View details for DOI 10.1002/mp.17634

https://orcid.org/0009-0006-3198-2934