Arishna Patel

All Publications

• Who Interviews Residency Applicants? A National Study of Pediatric Programs' Practices. Academic pediatrics Patel, A., Yemane, L., Rassbach, C. E. 2025: 102842

  Abstract

  Interviews play a critical role in assessing applicants for residency. Historically these interviews have been conducted primarily by faculty; however, in recent years, more programs have begun using non-faculty interviewers. We aimed to characterize the identity, prevalence, motivations behind, and perceived benefits and challenges of utilizing non-faculty interviewers during pediatric residency recruitment.We developed and distributed a survey to program leaders of all US categorical pediatric residencies from September - December 2022 to inquire about their interview methods. We analyzed the data using descriptive statistics and inductive content analysis for free-text responses.The response rate was 65% (125/193 programs). Overall, 71% of programs used non-faculty interviewers, with the most common groups being chief residents (if not considered clinical faculty) (58%), residents (31%), and fellows (14%). Perceived benefits of non-faculty interviewers included providing diverse perspectives in evaluating applicants and increasing the number of interviewers. Noted challenges were scheduling difficulties, assuring adequate training and preparation, and uncertainty of applicant perceptions of interviewing with non-faculty members. Many programs felt that each non-faculty interviewer group positively or very positively impacted residency interviews (71%, 87/123).Many programs utilize non-faculty interviewers during pediatric residency recruitment. Respondents described several perceived benefits and challenges related to these interviewers and overall felt their inclusion positively impacted recruitment. These study findings can serve as a resource for program leaders seeking to evaluate and evolve their current interview practices.

  View details for DOI 10.1016/j.acap.2025.102842

  View details for PubMedID 40254053

• Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1. Nature neuroscience Yang, X., Xu, B., Mulvey, B., Evans, M., Jordan, S., Wang, Y. D., Pagala, V., Peng, J., Fan, Y., Patel, A., Peng, J. C. 2019; 22 (3): 362-373

  Abstract

  UTX is a chromatin modifier required for development and neural lineage specification, but how it controls these biological processes is unclear. To determine the molecular mechanisms of UTX, we identified novel UTX protein interaction partners. Here we show that UTX and 53BP1 directly interact and co-occupy promoters in human embryonic stem cells and differentiating neural progenitor cells. Human 53BP1 contains a UTX-binding site that diverges from its mouse homolog by 41%, and disruption of the 53BP1-UTX interaction abrogated human, but not mouse, neurogenesis in vitro. The 53BP1-UTX interaction is required to upregulate key neurodevelopmental genes during the differentiation of human embryonic stem cells into neurons or into cortical organoids. 53BP1 promotes UTX chromatin binding, and in turn H3K27 modifications and gene activation, at a subset of genomic regions, including neurogenic genes. Overall, our data suggest that the 53BP1-UTX interaction supports the activation of key genes required for human neurodevelopment.

  View details for DOI 10.1038/s41593-018-0328-5

  View details for PubMedID 30718900

  View details for PubMedCentralID PMC6511450