Clinical Focus

  • Neurological Surgery

Academic Appointments

Professional Education

  • Residency: Massachusetts General Hospital Neurosurgery Program (2023) MA
  • Medical Education: Harvard Medical School (2016) MA

All Publications

  • Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex. Nature neuroscience Paulk, A. C., Kfir, Y., Khanna, A. R., Mustroph, M. L., Trautmann, E. M., Soper, D. J., Stavisky, S. D., Welkenhuysen, M., Dutta, B., Shenoy, K. V., Hochberg, L. R., Richardson, R. M., Williams, Z. M., Cash, S. S. 1800


    Recent advances in multi-electrode array technology have made it possible to monitor large neuronal ensembles at cellular resolution in animal models. In humans, however, current approaches restrict recordings to a few neurons per penetrating electrode or combine the signals of thousands of neurons in local field potential (LFP) recordings. Here we describe a new probe variant and set of techniques that enable simultaneous recording from over 200 well-isolated cortical single units in human participants during intraoperative neurosurgical procedures using silicon Neuropixels probes. We characterized a diversity of extracellular waveforms with eight separable single-unit classes, with differing firing rates, locations along the length of the electrode array, waveform spatial spread and modulation by LFP events such as inter-ictal discharges and burst suppression. Although some challenges remain in creating a turnkey recording system, high-density silicon arrays provide a path for studying human-specific cognitive processes and their dysfunction at unprecedented spatiotemporal resolution.

    View details for DOI 10.1038/s41593-021-00997-0

    View details for PubMedID 35102333