Contact

  • Academic
    aakwan@stanford.edu
    University - Student Department: Computer Science Position: Graduate

Additional Info

  • Mail Code: 9025

All Publications

  • Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation. Nature nanotechnology Purohit, M. P., Yu, B. J., Roy, K. S., Xiang, Y., Ewbank, S. N., Azadian, M. M., Hart, A. R., Muwanga, G. P., Martinez, P. J., Wang, J. B., Taoube, A. K., Markarian, E., Macedo, N., Kwan, A. K., Lopez, D. G., Airan, R. D. 2025

    Abstract

    Stimulus-responsive drug delivery nanotechnologies promise noninvasive activation of the right drug at the right place at the right time. However, these systems often incorporate non-validated pharmaceutical excipients and other features that limit their clinical translation. Here we engineer the responsiveness of liposomes to a pulsed, low-intensity ultrasound activating stimulus by incorporating a generally regarded as safe excipient that alters the acoustic properties of the liposome core medium. We show that this approach permits loading and ultrasound-induced release of four drugs in vitro. We then leverage this performance to enable drug-mediated noninvasive neuromodulation of each of the central and the peripheral nervous system in vivo. These acoustically activatable liposomes formulated with common and validated pharmaceutical excipients and production processes provide a versatile system for stimulus-responsive site-targeted drug delivery and noninvasive neuromodulation, with high clinical translation potential.

    View details for DOI 10.1038/s41565-025-01990-5

    View details for PubMedID 40826187

    View details for PubMedCentralID 7372945

  • A Clustering Approach for Personalized Coaching Applications Van Buren, A., Kwan, A., Rietdijk, H. H., Dijkhuis, T. B., Conde-Cespedes, P., Oldenhuis, H., Trocan, M. edited by Nguyen, N. T., Franczyk, B., Ludwig, A., Nunez, M., Treur, J., Vossen, G., Kozierkiewicz, A. SPRINGER INTERNATIONAL PUBLISHING AG. 2024: 351-363

    View details for DOI 10.1007/978-3-031-70259-4_27

    View details for Web of Science ID 001331194300027

  • Pharmacokinetics-Pharmacodynamics Dissociation Indicative of Ketamine-Induced Plasticity as Revealed by Ultrasonic Ketamine Uncaging in Rat Medial Prefrontal Cortex Yu, B., Roy, K., Purohit, M., Xiang, Y., Azadian, M., Taoube, A., Kwan, A., Lopez, D., Airan, R. SPRINGERNATURE. 2023: 277-278

    View details for Web of Science ID 001126640300117