Stanford University School of Medicine M.D. '25
University of Cambridge MPhil in Epidemiology '21, using advanced biostatistics to enhance predictive validity of cardiovascular disease biomarkers.
Harvard College A.B. with Honors in Human Evolutionary Biology, Minor in Chemistry '20
Education & Certifications
MPhil, University of Cambridge, Epidemiology (2021)
A.B., Harvard College, Human Evolutionary Biology, Minor in Chemistry (2020)
Galectin-3 and HFpEF: Clarifying an Emerging Relationship.
Current cardiology reviews
HFpEF is a leading cause of death whose burden is projected to increase in the coming decades. The aim of this paper is to interrogate the relationship between levels of circulating galectin-3, an emerging risk factor for cardiovascular disease, and the clinical diagnosis of HFpEF.The authors reviewed peer-reviewed literature and 18 studies met inclusion criteria. Study characteristics, study outcome definitions, assay characteristics, main findings, and measures of association were tabulated and summarized.Five studies found significant associations between galectin-3 and HFpEF diagnosis compared to healthy controls, and one did not. Five studies found significant associations between levels of circulating galectin-3 and severity of diastolic dysfunction. Three studies found significant associations between galectin-3 and all-cause mortality or rehospitalization. Two studies found levels of circulating galectin-3 to be a statistically significant predictor of later HFpEF onset. Finally, two studies examined whether galectin-3 was associated with incident HFpEF, one found a significant association and the other did not.Given the paucity of effective therapeutics for HFpEF, galectin-3 shows promise as a possible HFpEF-linked biomarker that may, with further study, inform and predict treatment course to reduce morbidity and mortality.
View details for DOI 10.2174/1573403X19666230320165821
View details for PubMedID 36959138
Galectin-3 is Associated with Heart Failure Incidence: A Meta-Analysis.
Current cardiology reviews
INTRODUCTION: Heart failure (HF) is a leading cause of death worldwide. The global prevalence of heart failure is projected to increase rapidly in the coming decades, and significant attention has turned to improve biomarker-based risk prediction of incident HF. This paper aimed to qualitatively and quantitatively evaluate the evidence associating levels of galectin-3 with the risk of incident HF.METHODS: A review of PUBMED-indexed peer-reviewed literature was performed. Nine studies met the inclusion criteria, and all nine had data eligible for conversion and pooling. A random-effects meta-analysis was performed using hazard ratios and 95% confidence intervals from a minimally adjusted model, a further adjusted model, and from subgroups within the further-adjusted model.RESULTS: The minimally-adjusted model provided an HR of 1.97 (95% CI 1.74-2.23) when comparing the top quartile of log-gal-3 to the bottom quartile. The further-adjusted model provided an HR of 1.32 (95% CI 1.21-1.44) for the same comparison. The positive, significant association was conserved during sensitivity analysis.CONCLUSION: There is a significant positive association between circulating galectin-3 and the risk of incident heart failure. Given the complex mechanistic relationship between galectin-3 and cardiovascular pathophysiology, further investigation is recommended for the possible implementation of galectin-3 into clinical risk prediction models.
View details for DOI 10.2174/1573403X19666221117122012
View details for PubMedID 36397629
Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction?
EVOLUTION MEDICINE AND PUBLIC HEALTH
2021; 9 (1): 248-255
View details for DOI 10.1093/emph/eoab016
View details for Web of Science ID 000745780600001
Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine.
Journal of visualized experiments : JoVE
Hemorrhage remains the leading cause of preventable deaths in trauma. Endovascular management of non-compressible torso hemorrhage has been at the forefront of trauma care in recent years. Since complete aortic occlusion presents serious concerns, the concept of partial aortic occlusion has gained a growing attention. Here, we present a large animal model of hemorrhagic shock to investigate the effects of a novel partial aortic balloon occlusion catheter and compare it with a catheter that works on the principles of complete aortic occlusion. Swine are anesthetized and instrumented in order to conduct controlled fixed-volume hemorrhage, and hemodynamic and physiological parameters are monitored. Following hemorrhage, aortic balloon occlusion catheters are inserted and inflated in the supraceliac aorta for 60 min, during which the animals receive whole-blood resuscitation as 20% of the total blood volume (TBV). Following balloon deflation, the animals are monitored in a critical care setting for 4 h, during which they receive fluid resuscitation and vasopressors as needed. The partial aortic balloon occlusion demonstrated improved distal mean arterial pressures (MAPs) during the balloon inflation, decreased markers of ischemia, and decreased fluid resuscitation and vasopressor use. As swine physiology and homeostatic responses following hemorrhage have been well-documented and are like those in humans, a swine hemorrhagic shock model can be used to test various treatment strategies. In addition to treating hemorrhage, aortic balloon occlusion catheters have become popular for their role in cardiac arrest, cardiac and vascular surgery, and other high-risk elective surgical procedures.
View details for DOI 10.3791/58284
View details for PubMedID 30199035
View details for PubMedCentralID PMC6231876