Professional Education


  • Doctor of Philosophy, Ruprecht Karl Universitat Heidelberg (2017)
  • Master of Science, Ruprecht Karl Universitat Heidelberg (2012)
  • Bachelor of Medicine, Peking University (2009)

All Publications


  • Multi-Omics Profiling, Microscopic Cervical Remodeling, and Parturition: Insights from the Smart Diaphragm Study. Liang, L., Dunn, J. P., Chen, S., Tsai, M., Hornburg, D., Newmann, S., Avina, M., Leng, Y., Holman, R., Lee, T. H., Qureshi, S., Montelongo, E., Zhao, B., Jeliffe, L., Snyder, M., Rand, L. SAGE PUBLICATIONS INC. 2019: 216A
  • Smart Diaphragm Study: Multi-omics profiling and cervical device measurements during pregnancy Liang, L., Dunn, J. P., Chen, S., Tsai, M., Hornburg, D., Newmann, S., Chung, P., Avina, M., Leng, Y., Holman, R., Lee, T. H., Berrios, S., Qureshi, S. A., Baer, R., Etemadi, M., Montelongo, E., Paynter, R., Zhao, B., Roy, S., Jelliffe, L., Snyder, M., Rand, L. MOSBY-ELSEVIER. 2019: S649
  • The role of translationally controlled tumor protein in proliferation of Drosophila intestinal stem cells. Proceedings of the National Academy of Sciences of the United States of America Kwon, Y. V., Zhao, B., Xu, C., Lee, J., Chen, C. L., Vinayagam, A., Edgar, B. A., Perrimon, N. 2019

    Abstract

    Translationally controlled tumor protein (TCTP) is a highly conserved protein functioning in multiple cellular processes, ranging from growth to immune responses. To explore the role of TCTP in tissue maintenance and regeneration, we employed the adult Drosophila midgut, where multiple signaling pathways interact to precisely regulate stem cell division for tissue homeostasis. Tctp levels were significantly increased in stem cells and enteroblasts upon tissue damage or activation of the Hippo pathway that promotes regeneration of intestinal epithelium. Stem cells with reduced Tctp levels failed to proliferate during normal tissue homeostasis and regeneration. Mechanistically, Tctp forms a complex with multiple proteins involved in translation and genetically interacts with ribosomal subunits. In addition, Tctp increases both Akt1 protein abundance and phosphorylation in vivo. Altogether, Tctp regulates stem cell proliferation by interacting with key growth regulatory signaling pathways and the translation process in vivo.

    View details for DOI 10.1073/pnas.1910850116

    View details for PubMedID 31843907

    View details for PubMedCentralID PMC6936429