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  • Methylation of CpG Dinucleotides in AAV Vector Plasmids Reduces TLR9 Immune Activation Patil, R., Hamilton, B., Perriman, R., Wright, J. CELL PRESS. 2022: 66-67
  • Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes. Frontiers in immunology Hamilton, B. A., Wright, J. F. 2021; 12: 675897


    Host immune responses that limit durable therapeutic gene expression and cause clinically significant inflammation remain a major barrier to broadly successful development of adeno-associated virus (AAV)-based human gene therapies. In this article, mechanisms of humoral and cellular immune responses to the viral vector are discussed. A perspective is provided that removal of pathogen-associated molecular patterns in AAV vector genomes to prevent the generation of innate immune danger signals following administration is a key strategy to overcome immunological barriers.

    View details for DOI 10.3389/fimmu.2021.675897

    View details for PubMedID 34084173