John Wright, Postdoctoral Faculty Sponsor
Methylation of CpG Dinucleotides in AAV Vector Plasmids Reduces TLR9 Immune Activation
CELL PRESS. 2022: 66-67
View details for Web of Science ID 000794043700125
ITRS FROM AAV SEROTYPES DIFFERENTIALLY STIMULATE INNATE IMMUNE SIGNALING THROUGH TLR9
ELSEVIER SCIENCE INC. 2022: S92
View details for Web of Science ID 000890643400145
Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes.
Frontiers in immunology
2021; 12: 675897
Host immune responses that limit durable therapeutic gene expression and cause clinically significant inflammation remain a major barrier to broadly successful development of adeno-associated virus (AAV)-based human gene therapies. In this article, mechanisms of humoral and cellular immune responses to the viral vector are discussed. A perspective is provided that removal of pathogen-associated molecular patterns in AAV vector genomes to prevent the generation of innate immune danger signals following administration is a key strategy to overcome immunological barriers.
View details for DOI 10.3389/fimmu.2021.675897
View details for PubMedID 34084173