Bradley Hamilton

All Publications

• Methylation of CpG Dinucleotides in AAV Vector Plasmids Reduces TLR9 Immune Activation Patil, R., Hamilton, B., Perriman, R., Wright, J. CELL PRESS. 2022: 66-67

  View details for Web of Science ID 000794043700125

• ITRS FROM AAV SEROTYPES DIFFERENTIALLY STIMULATE INNATE IMMUNE SIGNALING THROUGH TLR9 Hamilton, B., Patil, R., Wright, F. ELSEVIER SCIENCE INC. 2022: S92

  View details for Web of Science ID 000890643400145

• Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes. Frontiers in immunology Hamilton, B. A., Wright, J. F. 2021; 12: 675897

  Abstract

  Host immune responses that limit durable therapeutic gene expression and cause clinically significant inflammation remain a major barrier to broadly successful development of adeno-associated virus (AAV)-based human gene therapies. In this article, mechanisms of humoral and cellular immune responses to the viral vector are discussed. A perspective is provided that removal of pathogen-associated molecular patterns in AAV vector genomes to prevent the generation of innate immune danger signals following administration is a key strategy to overcome immunological barriers.

  View details for DOI 10.3389/fimmu.2021.675897

  View details for PubMedID 34084173