Wu Tsai Neurosciences Institute
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Cholawat Pacharinsak, DVM, PhD
Associate Professor of Comparative MedicineOn Leave from 08/21/2023 To 12/31/2023
BioCholawat Pacharinsak, DVM, PhD Associate Professor and Director of Anesthesia, Pain Management, and Surgery, at Stanford University’s Department of Comparative Medicine; he is a Diplomate of the American College of Veterinary Anesthesia and Analgesia (DACVAA). He received his DVM from Chulalongkorn University, Thailand and trained in an Anesthesiology/Pain Management residency program and received his Master's degree at Washington State University. He completed his PhD in Comparative and Molecular Biosciences from the University of Minnesota. Prior to arriving at Stanford, Dr. Pacharinsak was a faculty member in Anesthesiology and Pain Management at Michigan State University and Purdue University; and served as a Clinical Specialist at UCLA’s David Geffen School of Medicine. His research focuses on understanding the neurobiology of cancer pain, chemotherapeutic-induced peripheral neuropathy, acute surgical pain models, and methods to improve clinical pain management e.g. sustained release analgesics supporting refinement. Research methodology includes electrophysiologic and behavioral techniques.
Daniel Palanker, PhD
Professor of Ophthalmology and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsInteractions of electric field and light with biological cells and tissues and their applications to imaging, diagnostics, therapeutics and prosthetics, primarily in ophthalmology.
Specific fields of interest:
Electronic retinal prosthesis;
Electronic enhancement of tear secretion;
Electronic control of blood vessels;
Non-damaging retinal laser therapy;
Ultrafast laser surgery;
Interferometric imaging of neural signals;
Cell transplantation and retinal plasticity.
Professor of Neurosurgery, Emeritus
Current Research and Scholarly InterestsMembers of the Palmer Lab study the biology of neural stem cells in brain development and in the adult. Our primary goal is to understand how genes and environment synergize in influencing stem cell behavior during development and how mild genetic or environmental risk factors for disease may synergize in their detrimental effects on brain development or in the risk of neuronal loss in age-related degenerative disease.
David Jaehyun Park
Clinical Instructor, Neurosurgery
BioDavid Park, MD, PhD, is a neurosurgeon who graduated from medical school at the Catholic University of Korea in Seoul, South Korea. He then completed his internship and residency training in the Department of Neurosurgery at Seoul St. Mary’s Hospital. He became a board-certified neurosurgeon in South Korea in 2014 and subsequently completed a 2-year fellowship at the same hospital, specializing in brain tumor surgery and skull base surgery. During his residency, he also attended graduate school while practicing neurosurgery as a trainee and successfully defended his Ph.D. thesis, titled “Combination therapy for gliomas using temozolomide and interferon-beta secreting human bone marrow-derived mesenchymal stem cells,” in 2015.
After completing his fellowship in South Korea, Dr. Park moved to Singapore in 2016 and worked as a Clinical Fellow (Clinical Associate) at the National Neuroscience Institute for one year, focusing on Neurosurgical Oncology and Skull Base Surgery.
In 2017, Dr. Park joined Dr. Christian Badr’s lab at Massachusetts General Hospital, Harvard Medical School, as a Postdoctoral Research Fellow, conducting translational research on glioblastoma and studying the role of fatty acids and lipid metabolism in glioblastoma to complement his clinical expertise.
During this time, Dr. Park also launched a startup based on his invention of an intraoperative diagnostic tool for tumor detection during glioma surgery. He collaborated with bioengineers at M.I.T. to develop a prototype and secured seed funding from the MIT Sandbox Innovation Fund Program. As an alumnus of the MIT Sandbox program, he continues to develop this project.
In 2020, Dr. Park served as a Neurosurgical Oncology and Radiosurgery Fellow (Teaching Associate) for a year at North Shore University Hospital, Zucker School of Medicine at Hofstra/Northwell, in Long Island, New York, where he worked with Dr. Michael Schulder on brain tumor surgery including advanced techniques, such as Laser Interstitial Thermal Therapy (LITT) and Stereotactic Radiosurgery (SRS).
From July 2021 to June 2022, he completed another fellowship in Neurosurgical Oncology and Radiosurgery at the Cleveland Clinic in Cleveland. He devoted his efforts to minimally invasive neurosurgical techniques such as LITT and Gamma Knife SRS, as well as awake brain tumor surgery under the guidance of Drs. Gene Barnett, Lilyana Angelov, and Ali Mohammadi.
As of July 2022, Dr. Park has joined the Department of Neurosurgery at Stanford University as a Clinical Instructor, working with Dr. Steven D. Chang in the fields of Neurosurgical Oncology and CyberKnife SRS.
Karen J. Parker, PhD
Truong-Tan Broadcom Endowed Professor and Professor, by courtesy, of Comparative Medicine
Current Research and Scholarly InterestsThe Parker Lab conducts research on the biology of social functioning in monkeys, typically developing humans, and patients with social impairments.
Josef Parvizi, MD, PhD
Professor of Neurology and, by courtesy, of Neurosurgery
BioDr. Parvizi completed his medical internship at Mayo Clinic, neurology training at Harvard, and subspecialty training in clinical neurophysiology and epilepsy at UCLA before joining the Department of Neurology and Neurological Sciences at Stanford in 2007. Dr. Parvizi directs the Stanford Program for Medication Resistant Epilepsies and specializes in surgical treatments of intractable focal epilepsies. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience, where he leads a team of investigators to study the human brain. http://med.stanford.edu/parvizi-lab.html.
Anca M. Pasca, MD
Assistant Professor of Pediatrics
Current Research and Scholarly InterestsThe research focus of the lab is to understand molecular mechanisms underlying neurodevelopmental disorders associated with premature birth, neonatal and fetal brain injury with the long-term goal of translating the lab’s findings into therapeutics. The research team employs a multidisciplinary approach involving genetics, molecular and developmental neurobiology, animal models and neural cells differentiated from patient-derived induced pluripotent stem (iPS) cells. In particular, the lab is using a powerful 3D human brain-region specific organoid system developed at Stanford (Nature Methods, 2015; Nature Protocols, 2018) to ask questions about brain injury during development.
Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain.
Chirag Patel, MD, PhD
Member, Cardiovascular Institute
Current Research and Scholarly InterestsNeuro-oncology, Clinical Trials, Tumor Treating Fields (TTFields), Molecular/PET Imaging, Neuroimaging, Immunotherapy, Big Data Analysis
Zara Patel, MD
Professor of Otolaryngology - Head & Neck Surgery (OHNS)
BioDr. Zara M. Patel is Director of Endoscopic Skull Base Surgery and a Professor of Otolaryngology and, by courtesy, of Neurosurgery at Stanford. She was born and raised in St. Louis, completed her MD at the Oregon Health and Sciences University in Portland, Oregon and completed her residency training in otolaryngology at Mount Sinai Medical Center in New York, NY. After pursuing fellowship training in rhinology and endoscopic skull base surgery at Stanford University, she was recruited to join the Emory University faculty in Atlanta in 2011. After four years, the rhinology division recruited her back to the West coast to rejoin the department here at Stanford University in 2015.
Dr. Patel is an expert in advanced endoscopic sinus and skull base surgery. She treats patients with a wide variety of rhinologic complaints, including chronic sinus infection or inflammation, sinus disease that has failed medical therapy, sinus disease that has failed prior surgical therapy, cerebrospinal fluid leaks, benign and and malignant sinus and skull base tumors, as well as olfactory disorders.
She has served as Chair of the Education Committee and Member of the Board of Directors for the American Rhinologic Society and has developed a multitude of educational materials for both physicians and patients to help them better understand rhinologic disorders. She is passionate about educating patients to allow them to make the best decisions about their own care, leading to better outcomes.
Dr. Patel has published widely in topics such as avoiding complications in endoscopic sinus surgery, chronic rhinosinusitis in the immunosuppressed patient population, new devices and techniques for endoscopic skull base surgery, and olfactory dysfunction. She continues to perform research in these areas, and is currently collaborating with neuroscientists and engineers to develop technology that she hopes will eventually help cure patients with olfactory loss.
John M. Pauly
Reid Weaver Dennis Professor
BioInterests include medical imaging generally, and magnetic resonance imaging (MRI) in particular. Current efforts are focused on medical applications of MRI where real-time interactive imaging is important. Two examples are cardiac imaging, and the interactive guidance of interventional procedures. Specific interests include rapid methods for the excitation and acquisition of the MR signal, and the reconstruction of images from the data acquired using these approaches.
Kim Butts Pauly
Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering and of Bioengineering
Current Research and Scholarly InterestsWe are investigating and developing, and applying focused ultrasound in neuromodulation, blood brain barrier opening, and ablation for both neuro and body applications.
Director, H-STAR, David Jacks Professor of Education and Professor, by courtesy, of Computer Science
Current Research and Scholarly Interestslearning sciences focus on advancing theories, research, tools and social practices of technology-enhanced learning of complex domains
Jon-Paul Pepper, MD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsFacial paralysis is a debilitating condition that affects thousands of people. Despite excellent surgical technique, we are currently limited by the regenerative capacity of the body. The mission of our research is to identify new treatments that improve current facial paralysis treatments. We do this by exploring the regenerative cues that the body uses to restore tissue after nerve injury, in particular through pathways of neurogenesis and nerve repair in small mammals.
Claudia Katharina Petritsch
Associate Professor (Research) of Neurosurgery
Current Research and Scholarly InterestsThe Petritsch lab broadly investigates underlying causes for the intra-tumoral heterogeneity and immune suppression in brain tumors from a neuro-developmental perspective. Defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity in human brain tumors and may contribute to immune suppression. We use patient-derived models as avatars to study how brain cells control the fate of their progeny, whereby we unravel novel points of vulnerabilities in brain tumor cells.
Emma Pfeiffer Merner Professor of Medical Sciences
Current Research and Scholarly InterestsThe major focus of our research is to understand the molecular basis of inherited Parkinson's Disease (PD). We focus on the LRRK2 kinase that is inappropriately activated in PD and how it phosphorylates Rab GTPases, blocking the formation of primary cilia in specific regions of the brain. The absence of primary cilia renders cells unable to carry out Hedgehog signaling that is critical for neuroprotective pathways that sustain dopamine neurons.
Associate Professor (Research) of Radiology (Cancer Early Detection-Canary Center)
Current Research and Scholarly InterestsThe Pitteri laboratory is focused on the discovery and validation of proteins that can be used as molecular indicators of risk, diagnosis, progression, and recurrence of cancer. Proteomic technologies, predominantly mass spectrometry, are used to identify proteins in the blood that are differentially regulated and/or post-translationally modified with disease state. Using human plasma samples, tumor tissue, cancer cell lines, and genetically engineered mouse models, the origins of these proteins are being investigated. A major goal of this research is to define novel molecular signatures for breast and ovarian cancers, including particular sub-types of these diseases. This laboratory is also focused on the identification of proteins with expression restricted to the surface of cancer cells which can be used as novel targets for molecular imaging technologies.
Sylvia K. Plevritis, PhD
Professor of Biomedical Data Science and of Radiology (Integrative Biomedical Imaging Informatics at Stanford)
Current Research and Scholarly InterestsMy research program focuses on computational modeling of cancer biology and cancer outcomes. My laboratory develops stochastic models of the natural history of cancer based on clinical research data. We estimate population-level outcomes under differing screening and treatment interventions. We also analyze genomic and proteomic cancer data in order to identify molecular networks that are perturbed in cancer initiation and progression and relate these perturbations to patient outcomes.
Kilian M Pohl
Associate Professor (Research) of Psychiatry and Behavioral Sciences (Major Labs and Incubator) and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsThe foundation of the laboratory of Associate Professor Kilian M. Pohl, PhD, is computational science aimed at identifying biomedical phenotypes improving the mechanistic understanding, diagnosis, and treatment of neuropsychiatric disorders. The biomedical phenotypes are discovered by unbiased, machine learning-based searches across biological, neuroimaging, and neuropsychological data. This data-driven discovery currently supports the adolescent brain research of the NIH-funded National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) and the Adolescent Brain Cognitive Development (ABCD), the largest long-term study of brain development and child health in the US. The laboratory also investigates brain patterns specific to alcohol use disorder and the human immunodeficiency virus (HIV) across the adult age range, and have advanced the understanding of a variety of brain diseases including schizophrenia, Alzheimer’s disease, glioma, and aging.
Albert Ray Lang Professor of Psychology
Current Research and Scholarly InterestsOur lab uses the tools of cognitive neuroscience to understand how decision making, executive control, and learning and memory are implemented in the human brain. We also develop neuroinformatics tools and resources to help researchers make better sense of data.
Associate Professor of Electrical Engineering
Current Research and Scholarly InterestsOur research focuses on providing theoretical foundations and engineering platforms for realizing electronics that seamlessly integrate with the body. Such systems will allow precise recording or modulation of physiological activity, for advancing basic scientific discovery and for restoring or augmenting biological functions for clinical applications.
Sutardja Chuk Professor of Definitive and Curative Medicine
BioDr. Porteus was raised in California and was a local graduate of Gunn High School before completing A.B. degree in “History and Science” at Harvard University where he graduated Magna Cum Laude and wrote an thesis entitled “Safe or Dangerous Chimeras: The recombinant DNA controversy as a conflict between differing socially constructed interpretations of recombinant DNA technology.” He then returned to the area and completed his combined MD, PhD at Stanford Medical School with his PhD focused on understanding the molecular basis of mammalian forebrain development with his PhD thesis entitled “Isolation and Characterization of TES-1/DLX-2: A Novel Homeobox Gene Expressed During Mammalian Forebrain Development.” After completion of his dual degree program, he was an intern and resident in Pediatrics at Boston Children’s Hospital and then completed his Pediatric Hematology/Oncology fellowship in the combined Boston Chidlren’s Hospital/Dana Farber Cancer Institute program. For his fellowship and post-doctoral research he worked with Dr. David Baltimore at MIT and CalTech where he began his studies in developing homologous recombination as a strategy to correct disease causing mutations in stem cells as definitive and curative therapy for children with genetic diseases of the blood, particularly sickle cell disease. Following his training with Dr. Baltimore, he took an independent faculty position at UT Southwestern in the Departments of Pediatrics and Biochemistry before again returning to Stanford in 2010 as an Associate Professor. During this time his work has been the first to demonstrate that gene correction could be achieved in human cells at frequencies that were high enough to potentially cure patients and is considered one of the pioneers and founders of the field of genome editing—a field that now encompasses thousands of labs and several new companies throughout the world. His research program continues to focus on developing genome editing by homologous recombination as curative therapy for children with genetic diseases but also has interests in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemias and genetic diseases that affect the muscle. Clinically, Dr. Porteus attends at the Lucille Packard Children’s Hospital where he takes care of pediatric patients undergoing hematopoietic stem cell transplantation.
Kathleen Poston, MD, MS
Edward F. and Irene Thiele Pimley Professor of Neurology and the Neurological Sciences and Professor, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsMy research addresses one of the most devastating and poorly treated symptoms that can develop in people with Parkinson's disease - Dementia. We use multi-modal neuroimaging along with genetic and biological markers to understand the different underlying causes of dementia and to understand why dementia develops more quickly in some patients, but not others.
Associate Professor of Bioengineering, Senior Fellow at the Woods Institute for the Environment and Associate Professor, by courtesy, of Oceans and of Biology
BioWe use interdisciplinary approaches including theory and experiments to understand how computation is embodied in biological matter. Examples include cognition in single cell protists and morphological computing in animals with no neurons and origins of complex behavior in multi-cellular systems. Broadly, we invent new tools for studying non-model organisms with significant focus on life in the ocean - addressing fundamental questions such as how do cells sense pressure or gravity? Finally, we are dedicated towards inventing and distributing “frugal science” tools to democratize access to science (previous inventions used worldwide: Foldscope, Abuzz), diagnostics of deadly diseases like malaria and convening global citizen science communities to tackle planetary scale environmental challenges such as mosquito surveillance or plankton surveillance by citizen sailors mapping the ocean in the age of Anthropocene.
Adjunct Clinical Assistant Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsThe Priest lab seeks a better understanding of the genetics and pathogenesis of congenital heart disease using translational genomics, big-data, and vertebrate models of cardiac development.
Edward F. and Irene Thiele Pimley Professor of Neurology and the Neurological Sciences
Current Research and Scholarly InterestsExperiments examine
1)intrinsic properties of neuronal membranes; actions of neurotransmitters that regulate neocortical and thalamic excitability
2) chronic epileptogenesis following cortical injury; changes in intracortical connectivity and receptors;
3) effects of early injury and activity on cortical development/maldevelopment Electrophysiological, anatomical and pharmacological techniques employed.
4. prophylaxis of postraumatic epilepsy
5. Neocortical interneuronal function/modulation