Wu Tsai Neurosciences Institute
Showing 1-20 of 24 Results
Cholawat Pacharinsak, DVM, PhD
Assistant Professor of Comparative Medicine at the Stanford University Medical Center
BioCholawat Pacharinsak, DVM, PhD Assistant Professor and Director of Anesthesia, Pain Management, and Surgery, at Stanford University’s Department of Comparative Medicine; he is a Diplomate of the American College of Veterinary Anesthesia and Analgesia (DACVAA). He received his DVM from Chulalongkorn University, Thailand and trained in an Anesthesiology/Pain Management residency program and received his Master's degree at Washington State University. He completed his PhD in Comparative and Molecular Biosciences from the University of Minnesota. Prior to arriving at Stanford, Dr. Pacharinsak was a faculty member in Anesthesiology and Pain Management at Michigan State University and Purdue University; and served as a Clinical Specialist at UCLA’s David Geffen School of Medicine. His research focuses on understanding the neurobiology of cancer pain, chemotherapeutic-induced peripheral neuropathy, acute surgical pain models, and methods to improve clinical pain management e.g. sustained release analgesics supporting refinement. Research methodology includes electrophysiologic and behavioral techniques.
Daniel Palanker, PhD
Director of HEPL, Professor of Ophthalmology and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsInteractions of electric field and light with biological cells and tissues and their applications to imaging, diagnostics, therapeutics and prosthetics, primarily in ophthalmology.
Specific fields of interest:
Electronic retinal prosthesis;
Electronic enhancement of tear secretion;
Electronic control of blood vessels;
Non-damaging retinal laser therapy;
Ultrafast laser surgery;
Interferometric imaging of neural signals;
Cell transplantation and retinal plasticity.
Professor of Neurosurgery
Current Research and Scholarly InterestsMembers of the Palmer Lab study the biology of neural stem cells in brain development and in the adult. Our primary goal is to understand how genes and environment synergize in influencing stem cell behavior during development and how mild genetic or environmental risk factors for disease may synergize in their detrimental effects on brain development or in the risk of neuronal loss in age-related degenerative disease.
Karen J. Parker, PhD
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
Current Research and Scholarly InterestsThe Parker Lab conducts research on the biology of social functioning in monkeys, typically developing humans, and patients with social impairments.
Josef Parvizi, MD, PhD
Professor of Neurology and, by courtesy, of Neurosurgery at the Stanford University Medical Center
BioDr Parvizi completed his medical internship at Mayo Clinic and Neurology Residency at BIDMC Harvard Medical School before joining the UCLA for fellowship training in clinical neurophysiology and epilepsy. He has worked at Stanford University Medical Center since 2007 and specializes in treating patients with uncontrollable seizures. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience whose research activities have been supported by National Institute of Health, National Science Foundation, and private foundations. To find out more about Dr Parvizi's scholarly activities please visit http://med.stanford.edu/parvizi-lab.html.
Anca M. Pasca, MD
Assistant Professor of Pediatrics at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly InterestsThe research focus of the lab is to understand molecular mechanisms underlying neurodevelopmental disorders associated with premature birth, neonatal and fetal brain injury with the long-term goal of translating the lab’s findings into therapeutics. The research team employs a multidisciplinary approach involving genetics, molecular and developmental neurobiology, animal models and neural cells differentiated from patient-derived induced pluripotent stem (iPS) cells. In particular, the lab is using a powerful 3D human brain-region specific organoid system developed at Stanford (Nature Methods, 2015; Nature Protocols, 2018) to ask questions about brain injury during development.
Sergiu P. Pasca
Associate Professor of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
Our lab is using pluripotent stem cells derived non-invasively from human individuals to generate in a dish specific regions of the human brain in a functional 3D preparation we have developed. We are using months-to-years long ‘brain-a-dish’ cultures (also known as brain region-specific organoids or spheroids) to understand how neurons find their final position in the brain and how they mature functionally. To investigate how different brain regions talk to each-other in normal and diseased states, we introduced a new approach for in vitro assembly of neural circuits, also known as assembloids.
We employ state-of-the-art stem cell biology, genome engineering, imaging and neuroscience approaches to identify the dynamical processes that go awry in neural cells derived from patients with neuropsychiatric disorders, such as autism or schizophrenia, and what should be therapeutically targeted in these conditions.
Associate Professor of Otolaryngology/Head and Neck Surgery (Rhinology) and, by courtesy, of Neurosurgery at the Stanford University Medical Center
BioDr. Zara M. Patel is Director of Endoscopic Skull Base Surgery and an Associate Professor of Otolaryngology and, by courtesy, of Neurosurgery at Stanford. She was born and raised in St. Louis, completed her MD at the Oregon Health and Sciences University in Portland, Oregon and completed her residency training in otolaryngology at Mount Sinai Medical Center in New York, NY. After pursuing fellowship training in rhinology and endoscopic skull base surgery at Stanford University, she was recruited to join the Emory University faculty in Atlanta in 2011. After four years, the rhinology division recruited her back to the West coast to rejoin the department here at Stanford University.
Dr. Patel is an expert in advanced endoscopic sinus and skull base surgery. She treats patients with a wide variety of rhinologic complaints, including chronic sinus infection or inflammation, sinus disease that has failed medical therapy, sinus disease that has failed prior surgical therapy, cerebrospinal fluid leaks, benign and and malignant sinus and skull base tumors, as well as olfactory disorders.
She is immediate past-Chair of the Education Committee and now Member of the Board of Directors for the American Rhinologic Society and has developed a multitude of educational materials for both physicians and patients to help them better understand rhinologic disorders. She is passionate about educating patients to allow them to make the best decisions about their own care, leading to better outcomes.
Dr. Patel has published widely in topics such as avoiding complications in endoscopic sinus surgery, chronic rhinosinusitis in the immunosuppressed patient population, new devices and techniques for endoscopic skull base surgery, and olfactory dysfunction. She continues to perform research in these areas, and is beginning collaborative efforts with neuroscientists and engineers to develop technology that she hopes will eventually help cure patients with olfactory loss.
John M. Pauly
Reid Weaver Dennis Professor
BioInterests include medical imaging generally, and magnetic resonance imaging (MRI) in particular. Current efforts are focused on medical applications of MRI where real-time interactive imaging is important. Two examples are cardiac imaging, and the interactive guidance of interventional procedures. Specific interests include rapid methods for the excitation and acquisition of the MR signal, and the reconstruction of images from the data acquired using these approaches.
Kim Butts Pauly
Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering and of Bioengineering
Current Research and Scholarly InterestsWe are investigating and developing, and applying focused ultrasound in neuromodulation, blood brain barrier opening, and ablation for both neuro and body applications.
Director, H-STAR, David Jacks Professor of Education and Professor, by courtesy, of Computer Science
Current Research and Scholarly Interestslearning sciences focus on advancing theories, research, tools and social practices of technology-enhanced learning of complex domains
Claudia Katharina Petritsch
Associate Professor (Research) of Neurosurgery
Current Research and Scholarly InterestsWe study cell fate mechanisms to understand intra-tumoral heterogeneity and overcome therapy resistance and immune suppression in brain tumors.
Excessive proliferation, apoptotic evasion, and migratory spread are all hallmarks of tumorigenesis. However, these defects fail to explain the incredible heterogeneity and immune suppression observed in malignant brain tumors, two major hurdles to their treatment, which remains mostly palliative. Only once we elucidate the underlying biologic causes for heterogeneity and immune suppression, will we develop better treatment options for brain tumor patients and prevent malignant progression and tumor growth.
In the healthy brain, neural stem cells generate progenitors, which in turn give rise to differentiating cells that will eventually acquire their final functional state. Cell fate decisions within these hierarchical brain cell lineages are tightly controlled and irreversible: e.g. cells in the state of differentiation will not turn into progenitor cells or stem cells. It is known that brain tumor cells, on the other hand, defy many general principles of neurobiology. This is especially true for malignant glioma cells, which simultaneously express markers of different lineages and states exhibiting incomplete differentiation. Tumor cell hierarchies are poorly understood, providing no explanation for why tumor cells with stem-like, progenitor-like, and differentiated features co-exist and interact with normal brain cells and immune-infiltrating cells within a single tumor entity, and how this heterogeneity relates to the lack of active immune infiltration.
The Petritsch lab broadly investigates underlying causes for the intra-tumoral heterogeneity and immune suppression in brain tumors from a developmental neurobiology perspective. Defects in cell fate control could explain many key defects present in brain tumors and an understanding of how brain cells control the fate of their progeny may identify novel points of vulnerabilities to target with therapeutics. Of special emphasis, we study the establishment of cell fates within normal hierarchical brain lineages for comparison to the dysregulated cell-fate hierarchies seen in brain tumors. Our lab was the first to demonstrate that normal adult oligodendrocyte progenitor cells (OPCs) undergo asymmetric divisions to make cell fate decisions, i.e. to generate OPCs as well as differentiating cells each time they divide. Drawing from these data, we investigate whether brain tumors divide along hierarchical lineages and how oncogenic mutations might affect cell fate decisions within these hierarchies. A major line of investigation in our lab focuses on whether defects in asymmetric division lead to aberrant cell fate decisions that cause the paradigm mixed lineage phenotypes and the intra-tumoral heterogeneity present across tumors.
To study interactions of tumor cells and the immune system, we have developed and utilized transplantable mouse glioma models. We are tasked to facilitate and coordinate the distribution of fresh tissue from the neurosurgery operating room, and have access to fresh brain tissue from patient surgeries, from which we prepare cell culture models for brain tumors and normal progenitors. We complement our work with human cells with studies in genetically engineered mouse models of gliomagenesis to conduct molecular, cellular and bioinformatic analyses
Emma Pfeiffer Merner Professor in the Medical Sciences
Current Research and Scholarly InterestsThe major focuses of our research is to understand the molecular basis of inherited Parkinson's Disease (PD) and to elucidate the molecular mechanisms by which proteins and cholesterol are transported between specific membrane compartments. We focus on the LRRK2 kinase that is inappropriately activated in PD and how it phosphorylates Rab GTPases, blocking the formation of primary cilia in culture and specific regions of the brain.
Associate Professor (Research) of Radiology (Cancer Early Detection-Canary Center)
Current Research and Scholarly InterestsThe Pitteri laboratory is focused on the discovery and validation of proteins that can be used as molecular indicators of risk, diagnosis, progression, and recurrence of cancer. Proteomic technologies, predominantly mass spectrometry, are used to identify proteins in the blood that are differentially regulated and/or post-translationally modified with disease state. Using human plasma samples, tumor tissue, cancer cell lines, and genetically engineered mouse models, the origins of these proteins are being investigated. A major goal of this research is to define novel molecular signatures for breast and ovarian cancers, including particular sub-types of these diseases. This laboratory is also focused on the identification of proteins with expression restricted to the surface of cancer cells which can be used as novel targets for molecular imaging technologies.
Giles W Plant
Associate Professor of NeurosurgeryOn Partial Leave from 01/06/2020 To 01/04/2021
Current Research and Scholarly InterestsOur research focuses on the repair of the injured spinal cord. We investigate the following areas:
- Spinal cord injury (SCI): Axonal regeneration, myelination and gene therapy
- Stem cell transplantation (adult, embryonic and iPS)
- Endogenous stem cell activity after SCI
Kilian M Pohl
Associate Professor (Research) of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
Current Research and Scholarly InterestsThe foundation of the laboratory of Associate Professor Kilian M. Pohl, PhD, is computational science aimed at identifying biomedical phenotypes improving the mechanistic understanding, diagnosis, and treatment of neuropsychiatric disorders. The biomedical phenotypes are discovered by unbiased, machine learning-based searches across biological, neuroimaging, and neuropsychological data. This data-driven discovery currently supports the adolescent brain research of the NIH-funded National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) and the Adolescent Brain Cognitive Development (ABCD), the largest long-term study of brain development and child health in the US. The laboratory also investigates brain patterns specific to alcohol use disorder and the human immunodeficiency virus (HIV) across the adult age range, and have advanced the understanding of a variety of brain diseases including schizophrenia, Alzheimer’s disease, glioma, and aging.
Albert Ray Lang Professor of Psychology and Professor, by courtesy, of Computer Science
Current Research and Scholarly InterestsOur lab uses the tools of cognitive neuroscience to understand how decision making, executive control, and learning and memory are implemented in the human brain. We also develop neuroinformatics tools and resources to help researchers make better sense of data.
Associate Professor of Electrical Engineering
Current Research and Scholarly InterestsOur research focuses on providing theoretical foundations and engineering platforms for realizing electronics that seamlessly integrate with the body. Such systems will allow precise recording or modulation of physiological activity, for advancing basic scientific discovery and for restoring or augmenting biological functions for clinical applications.
Professor of Pediatrics (Stem Cell Transplantation)
Current Research and Scholarly InterestsGenome Editing and Population Dynamics for Gene Therapy and Cancer Research