Independent Labs, Institutes, and Centers (Dean of Research)
Showing 21-30 of 111 Results
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Karen J. Parker, PhD
Truong-Tan Broadcom Endowed Professor and Professor, by courtesy, of Comparative Medicine
Current Research and Scholarly InterestsThe Parker Lab conducts research on the biology of social functioning in monkeys, typically developing humans, and patients with social impairments.
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Vanessa Parli
Director of Research Programs, Institute for Human-Centered Artificial Intelligence (HAI)
BioVanessa Parli is the Director of Research at HAI. She leads the HAI grant programs, research convenings, student groups and “state of AI” reports such as the AI 100 and the AI Index where she is a member of the Steering Committee. Her team also analyzes the effectiveness of these programs to continuously improve HAI’s ability to foster interdisciplinary research collaborations internal and external to Stanford. Prior to Stanford, Vanessa worked in management consulting where she utilized statistics, machine learning and other data science methodologies to advise government agencies, large biotech companies and nonprofit organizations. Vanessa holds an MS in Engineering Management and Computational Mathematics from Johns Hopkins University and a BA in Industrial Engineering from Arizona State University.
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Josef Parvizi, MD, PhD
Professor of Neurology and Neurological Sciences (Adult Neurology) and, by courtesy, of Neurosurgery
BioDr. Parvizi completed his medical internship at Mayo Clinic, neurology training at Harvard, and subspecialty training in clinical neurophysiology and epilepsy at UCLA before joining the Department of Neurology and Neurological Sciences at Stanford in 2007. Dr. Parvizi directs the Stanford Program for Medication Resistant Epilepsies and specializes in surgical treatments of intractable focal epilepsies. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience, where he leads a team of investigators to study the human brain. http://med.stanford.edu/parvizi-lab.html.
Epilepsy patient story: https://www.youtube.com/watch?v=HXy-gXg0t94&t=3s -
Anca M. Pasca, MD
Assistant Professor of Pediatrics
Current Research and Scholarly InterestsThe research focus of the lab is to understand molecular mechanisms underlying neurodevelopmental disorders associated with premature birth, neonatal and fetal brain injury with the long-term goal of translating the lab’s findings into therapeutics. The research team employs a multidisciplinary approach involving genetics, molecular and developmental neurobiology, animal models and neural cells differentiated from patient-derived induced pluripotent stem (iPS) cells. In particular, the lab is using a powerful 3D human brain-region specific organoid system developed at Stanford (Nature Methods, 2015; Nature Protocols, 2018) to ask questions about brain injury during development.
https://www.neopascalab.org/ -
Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain. -
Chirag Patel, MD, PhD
Member, Cardiovascular Institute
Current Research and Scholarly InterestsNeuro-oncology, Clinical Trials, Tumor Treating Fields (TTFields), Molecular/PET Imaging, Neuroimaging, Immunotherapy, Big Data Analysis
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Michele Lanpher Patel
Instructor, Medicine - Stanford Prevention Research Center
BioMichele L. Patel, PhD is an Instructor in the Stanford University School of Medicine. Her research focuses on optimizing digital health interventions for treating & preventing obesity. Digital interventions have potential for serving as first-line obesity treatments given their accessibility, low cost, and personalization. Dr. Patel is interested in testing innovative strategies to enhance engagement in these digital interventions. Leveraging an 'intervention optimization' paradigm (the Multiphase Optimization Strategy, MOST), she examines the unique and combined weight loss effects of intervention strategies. Optimizing interventions facilitates maximizing clinical impact while minimizing patient burden and healthcare costs.
Dr. Patel received a career development award from NIH (K23; 2022-2027). This work investigates the most potent combination of self-monitoring strategies in a behavioral weight loss intervention for 176 adults with overweight or obesity. Dr. Patel is interested in using digital tools such as commercial apps, wearable devices, and text messaging to improve access to and engagement in treatment.
Dr. Patel received her BA in psychology from Duke University in 2010 and her PhD in clinical psychology from Duke in 2018. She completed her clinical internship at the VA Palo Alto, specializing in behavioral medicine, and her postdoctoral fellowship at the Stanford Prevention Research Center.
Primary Research Interests:
-- Conducting clinical trials to optimize & evaluate digital health interventions for obesity
-- Improving engagement in self-monitoring and other behavioral intervention strategies
-- Identifying psychosocial factors (e.g., health literacy, stress) that impact treatment success
Methods:
-- RCTs, including factorial designs
-- embedded trials (study-within-a-trial)
-- systematic reviews
-- signal detection analysis
-- mixed methods & qualitative methods
