Bioengineering
Showing 41-60 of 560 Results
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Lacramioara Bintu
Associate Professor of Bioengineering
BioLacra Bintu is an Associate Professor of Bioengineering and a member of the Biophysics Program and Bio-X Institute at Stanford University. She earned undergraduate degrees in Physics, Mathematics, and Neuroscience from Brandeis University. As an undergraduate working with Jane Kondev and Rob Phillips, she used statistical mechanics to model transcription factor binding and gene regulation. She completed her Physics Ph.D. at U.C. Berkeley with Carlos Bustamante, where she used single-molecule approaches to study transcription on nucleosomal templates. As a postdoctoral scholar at Caltech with Michael Elowitz, she used live-cell microscopy to investigate chromatin-mediated gene regulation.
Her group seeks to discover fundamental principles of gene regulation and advance mammalian synthetic biology, with an emphasis on causal mechanisms, dynamic responses, and single-cell variability that enable signal integration at the population level. The lab develops tools to manipulate gene expression, for example by recruiting chromatin, transcriptional, or RNA regulators to defined genomic loci, or building DNA regulatory elements such as signal-responsive enhancers or silencers. To assess gene regulation responses at scale, the lab is using and developing new sequencing and imaging based techniques such as: delivery of large DNA libraries to cells coupled with sorting based on fluorescent and magnetic reporters, time-lapse fluorescence microscopy and in situ sequencing, or single-molecule footprinting of transcription factors and nucleosomes binding in live cells. Her group uses mathematical modeling to capture the fundamental principles underlying the observed gene expression responses and to predict new behaviors. This work provides insight into epigenetic mechanisms underlying development, cancer, and immune function and informs strategies for gene therapies that correct aberrant expression states.
Lacra lives in Menlo Park with her husband Anton and son Manu. They enjoy hiking, cooking, reading, playing board games, and watching birds in their backyard with their two cats. -
Kwabena Boahen
Professor of Bioengineering and of Electrical Engineering
Current Research and Scholarly InterestsBoahen's group analyzes neural behavior computationally to elucidate principles of neural design at the cellular, circuit, and systems levels; and synthesizes neuromorphic electronic systems that scale energy-use with size as efficiently as the brain does. This interdisciplinary research program bridges neurobiology and medicine with electronics and computer science, bringing together these seemingly disparate fields.
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Jenn Brophy
Assistant Professor of Bioengineering
Current Research and Scholarly InterestsWe develop technologies that enable the genetic engineering of plants and their associated microbes with the goal of driving innovation in agriculture for a sustainable future. Our work is focused in synthetic biology and the reprogramming of plant development for enhanced environmental stress tolerance.
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Zev Bryant
Associate Professor of Bioengineering and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsMolecular motors lie at the heart of biological processes from DNA replication to vesicle transport. My laboratory seeks to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work.
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Vivek P. Buch, MD
Assistant Professor of Neurosurgery and, by courtesy, of Bioengineering
BioDr. Buch is a board certified neurosurgeon with fellowship training in pediatric and adult epilepsy, functional, and minimally invasive neurosurgery. He is an Assistant Professor of Neurosurgery and Bioengineering, and the Christina and Hamid Moghadam Endowed Faculty Scholar at Stanford University.
Dr. Buch focuses his expertise on the open and minimally invasive treatment of epilepsy, low grade brain tumors, movement and neuropsychiatric disorders, facial and body pain syndromes, and other complex neurological conditions. He uses advanced and innovative techniques to treat both pediatric and adult patients. For each patient, he develops a personalized care plan that is designed to be both comprehensive and compassionate.
Dr. Buch has conducted extensive research. His academic career goal is to develop restorative bioengineering approaches for complex neurocognitive, neurodevelopmental, and neuropsychiatric disorders. He is creating network-neuroprosthetics and precision molecular therapies to restore abnormal brain circuit function in these vulnerable patient populations. He is further pioneering novel intraoperative technologies including personalized network-based targeting, holographic mixed reality, and artificial intelligence platforms for minimally invasive cranial surgery. He has presented this work at numerous professional conferences at the national and international level.
He has co-authored articles on his research discoveries in Science, Nature, Nature Medicine, Nature Neuroscience, Nature Communications, Neuron, Brain, Annals of Surgery, New England Journal of Medicine, ACS Nano, and many other journals. Articles focus on developing novel network control theory applications to human brain functions and new techniques and technologies to enhance neurosurgical effectiveness and patient outcomes.
He is the AI/Data Science Section Editor for NEUROSURGERY, and a guest editor for Surgical Innovation and Brain Sciences. He also has co-authored chapters in the books Neurosurgical Atlas, Operative Techniques in Epilepsy Surgery, Deep Brain Stimulation, and The Encyclopedia of Medical Robotics.
For his clinical, research, and academic achievements. Dr. Buch has earned many honors. He has won awards from the American Association of Neurological Surgeons, American Roentgen Ray Society, Congress of Neurological Surgeons, and National Institutes of Health, including twice earning the honor of national Young Neurosurgeon award from the Congress of Neurological Surgeons in his first 5 years of practice.
Dr. Buch is a national leader in epilepsy surgery, functional neurosurgery, and surgical AI. He is a member of the Wu Tsai Neuroscience Institute, Human Performance Alliance, Stanford BioX, and Human Centered AI Institute. He is also a member of the American Association of Neurological Surgeons, Congress of Neurological Surgeons, World Society for Stereotactic and Functional Neurosurgery, American Association of Stereotactic and Functional Neurosurgery, American Epeilepsy Soeciety, and Alpha Omega Alpha Medical Honor Society.
He has designed and holds patents on artificial intelligence systems for surgical guidance, neural control signals for closed-loop stimulation therapy, novel arrays for bioelectrical sensing and stimulation, and surgical devices including percutaneous anchoring mechanisms and digital neurological assessment tools.
Essential tremor patient story: https://www.youtube.com/watch?v=fV6BzyU9b3c
Parkinson's disease patient story: https://www.youtube.com/watch?v=vAKP7SRKs08
Epilepsy patient story: https://www.youtube.com/watch?v=HXy-gXg0t94&t=3s
Deep brain stimulation treatment: https://www.youtube.com/watch?v=xLgEcb447gA&t=1s
Laser interstitial thermal therapy treatment: https://www.youtube.com/watch?v=z-nRUMbs2kY&t=2s
MR-guided focused ultrasound treatment: https://www.youtube.com/watch?v=3Bwq2YxD9eU
