School of Engineering
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Lynette Cegelski
Monroe E. Spaght Professor of Chemistry and Professor, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsOur laboratory uncovers the chemical principles that organize living systems. Across biology - from microbial communities to human disease - chemical and macromolecular composition, molecular interactions, and chemical modifications govern the assembly, function, and persistence of complex biological systems, yet many of these principles remain hidden from conventional approaches. We develop innovative chemical, structural, and biological strategies to preserve and interrogate intact biological systems, revealing chemistry that cannot be observed by studying isolated components alone. Our work has uncovered previously unknown molecular structures, chemical modifications, and mechanisms of biological organization, including the discovery of phosphoethanolamine (pEtN) cellulose, a chemically modified form of cellulose that fundamentally changed our understanding of bacterial extracellular matrices.
In parallel, we discover and engineer molecules that probe, disrupt, and control biological systems. A major focus is the development of new strategies to combat antibiotic resistance and persistent bacterial communities. Our laboratory has introduced first-in-class vancomycin conjugates with multiple modes of action, unusually broad-spectrum activity, and the ability to sterilize biofilms - properties not observed together in other vancomycin conjugates. We also develop anti-biofilm agents, molecular probes, imaging agents, and other chemical tools that both reveal new biology and provide starting points for addressing pressing challenges in human health and disease.
Together, our research spans fundamental chemical discovery and molecular invention: uncovering the chemistry that enables biological systems to assemble and persist, and using those insights to create new ways to interrogate and control them. This work opens opportunities to combat infectious disease, improve human health, preserve marine ecosystems, advance sustainable materials, and deepen our understanding of how chemistry organizes life. -
Rahul Chajwa
Basic Life Research Scientist, Bioengineering
Current Research and Scholarly InterestsMy HFSP project is focussed on understanding the birth, life and death of marine snow. A predictive understanding of the hydrodynamic, biotic, and non-equilibrium aspects of this sinking microbial ecosystem is a notoriously challenging and globally relevant problem and is the central theme of my research at Stanford University. I’m applying my training as a physicist to shed light on the dynamical aspects of microbial life in the ocean, and to contribute insights that can help mitigate the negative impact of human activities on global climate; something I feel strongly about.
