School of Engineering


Showing 1-20 of 40 Results

  • Monther Abu-Remaileh

    Monther Abu-Remaileh

    Assistant Professor of Chemical Engineering and, by courtesy, of Genetics

    BioThe Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. We also study how these pathways go awry in human diseases such as cancer, neurodegeneration and metabolic syndrome, in order to engineer new therapeutic modalities.

    To address these questions, our lab uses a multidisciplinary approach to study the biochemical functions of the lysosome in vitro and in vivo. Lysosomes are membrane-bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. Lysosomal function is critical for organismal homeostasis—mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome.

    By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. Using insights from our research, we will engineer novel therapies to modulate the pathways that govern human disease.

  • Zhenan Bao

    Zhenan Bao

    K. K. Lee Professor, and Professor, by courtesy, of Materials Science and Engineering and of Chemistry

    BioZhenan Bao joined Stanford University in 2004. She is currently a K.K. Lee Professor in Chemical Engineering, and with courtesy appointments in Chemistry and Material Science and Engineering. She is the Department Chair of Chemical Engineering from 2018. She is a member of the National Academy of Engineering, the American Academy of Arts and Sciences and the National Academy of Inventors. She founded the Stanford Wearable Electronics Initiative (eWEAR) and is the current faculty director. She is also an affiliated faculty member of Precourt Institute, Woods Institute, ChEM-H and Bio-X. Professor Bao received her Ph.D. degree in Chemistry from The University of Chicago in 1995 and joined the Materials Research Department of Bell Labs, Lucent Technologies. She became a Distinguished Member of Technical Staff in 2001. Professor Bao currently has more than 700 refereed publications and more than 100 US patents. She served as a member of Executive Board of Directors for the Materials Research Society and Executive Committee Member for the Polymer Materials Science and Engineering division of the American Chemical Society. She was an Associate Editor for the Royal Society of Chemistry journal Chemical Science, Polymer Reviews and Synthetic Metals. She serves on the international advisory board for Advanced Materials, Advanced Energy Materials, ACS Nano, Accounts of Chemical Reviews, Advanced Functional Materials, Chemistry of Materials, Chemical Communications, Journal of American Chemical Society, Nature Asian Materials, Materials Horizon and Materials Today. She is one of the Founders and currently sits on the Board of Directors of C3 Nano Co. and PyrAmes, both are silicon valley venture funded companies. She is Fellow of AAAS, ACS, MRS, SPIE, ACS POLY and ACS PMSE. She was a recipient of the ACS Award of Chemistry of Materials 2022, MRS Mid-Career Award in 2021, AICHE Alpha Chi Sigma Award 2021, ACS Central Science Disruptor and Innovator Prize in 2020, ACS Gibbs Medal in 2020, the Wilhelm Exner Medal from the Austrian Federal Minister of Science in 2018, the L'Oreal UNESCO Women in Science Award North America Laureate in 2017. She was awarded the ACS Applied Polymer Science Award in 2017, ACS Creative Polymer Chemistry Award in 2013 ACS Cope Scholar Award in 2011, and was selected by Phoenix TV, China as 2010 Most influential Chinese in the World-Science and Technology Category. She is a recipient of the Royal Society of Chemistry Beilby Medal and Prize in 2009, IUPAC Creativity in Applied Polymer Science Prize in 2008, American Chemical Society Team Innovation Award 2001, R&D 100 Award, and R&D Magazine Editors Choice Best of the Best new technology for 2001. She has been selected in 2002 by the American Chemical Society Women Chemists Committee as one of the twelve Outstanding Young Woman Scientist who is expected to make a substantial impact in chemistry during this century. She is also selected by MIT Technology Review magazine in 2003 as one of the top 100 young innovators for this century. She has been selected as one of the recipients of Stanford Terman Fellow and has been appointed as the Robert Noyce Faculty Scholar, Finmeccanica Faculty Scholar and David Filo and Jerry Yang Faculty Scholar.

  • Stacey Bent

    Stacey Bent

    Vice Provost for Graduate Education & Postdoctoral Affairs, Jagdeep & Roshni Singh Professor in the School of Engineering, Senior Fellow at Precourt and Professor, by courtesy, of Materials Science & Eng, of Electrical Eng and of Chemistry

    BioThe research in the Bent laboratory is focused on understanding and controlling surface and interfacial chemistry and applying this knowledge to a range of problems in semiconductor processing, micro- and nano-electronics, nanotechnology, and sustainable and renewable energy. Much of the research aims to develop a molecular-level understanding in these systems, and hence the group uses of a variety of molecular probes. Systems currently under study in the group include functionalization of semiconductor surfaces, mechanisms and control of atomic layer deposition, molecular layer deposition, nanoscale materials for light absorption, interface engineering in photovoltaics, catalyst and electrocatalyst deposition.

  • Matteo Cargnello

    Matteo Cargnello

    Assistant Professor of Chemical Engineering and, by courtesy, of Materials Science and Engineering

    BioMatteo Cargnello is Assistant Professor of Chemical Engineering and Terman Faculty Fellow. His group research interests are in the preparation and use of uniform and tailored materials for heterogeneous catalysis and photocatalysis and the technological exploitation of nanoparticles and nanocrystals. Reactions of interest are related to sustainable energy generation and use, control of emissions of greenhouse gases, and better utilization of abundant building blocks (methane, biomass). Dr. Cargnello received his Ph.D. in Nanotechnology in 2012 at the University of Trieste (Italy) and he was then a post-doctoral scholar in the Chemistry Department at the University of Pennsylvania (Philadelphia) before joining the Faculty at Stanford.

  • Lynette Cegelski

    Lynette Cegelski

    Associate Professor of Chemistry and, by courtesy, of Chemical Engineering

    Current Research and Scholarly InterestsOur research program integrates chemistry, biology, and physics to investigate the assembly and function of macromolecular and whole-cell systems. The genomics and proteomics revolutions have been enormously successful in generating crucial "parts lists" for biological systems. Yet, for many fascinating systems, formidable challenges exist in building complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell factories. We are inspired by the need for new and unconventional approaches to solve these outstanding problems and to drive the discovery of new therapeutics for human disease.

    Our approach is different from the more conventional protein-structure determinations of structural biology. We employ biophysical and biochemical tools, and are designing new strategies using solid-state NMR spectroscopy to examine assemblies such as amyloid fibers, bacterial cell walls, whole cells, and biofilms. We would like to understand at a molecular and atomic level how bacteria self-assemble extracellular structures, including functional amyloid fibers termed curli, and how bacteria use such building blocks to construct organized biofilm architectures. We also employ a chemical genetics approach to recruit small molecules as tools to interrupt and interrogate the temporal and spatial events during assembly processes and to develop new strategies to prevent and treat infectious diseases. Overall, our approach is multi-pronged and provides training opportunities for students interested in research at the chemistry-biology interface.

  • Ying Chih Chang

    Ying Chih Chang

    Adjunct Professor

    BioDr. Ying Chang is an Adjunct Professor of the Department of Chemical Engineering, an affiliate member of Precision Health and Integrated Diagnostic Center of the School of Medicine, and a Co-Director of the Taiwan-Stanford Partnership program, LEAP, at Stanford University. She is also a Research Fellow at the Genomics Research Center, Academia Sinica, and an Adjunct Professor at the Center of Liquid Biopsy at Kaohsiung Medical University, Taiwan. Formerly, she was an Assistant Professor in the Department of Chemical Engineering and Materials Science, and the Department of Biomedical Engineering at the University of California-Irvine, Irvine, CA. Prior to her academic appointments, Dr. Chang had worked in various industrial R&D laboratories including as a Senior Engineer for the hard drive media at Maxmedia California, San Jose, CA (now Seagate), a Postdoctoral Scientist for the materials design of GeneChip at Affymetrix Corp, Santa Clara, CA (now Thermal Fisher Scientific). Her recent invention in circulating tumor cells platform has led to a startup company, Cellmax Life in 2013. Highlights of her research include integrated nanomaterials, microfluidics, and bioreactors to control stem cell fates for tissue engineering and liquid biopsy for cancer diagnostics and precision medicine. Dr. Chang received her BS from National Taiwan University and PhD from Stanford University in Chemical Engineering.

  • Jennifer R. Cochran

    Jennifer R. Cochran

    Shriram Chair of the Department of Bioengineering, Professor of Bioengineering and, by courtesy, of Chemical Engineering

    Current Research and Scholarly InterestsMolecular Engineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology

  • Joseph M. DeSimone

    Joseph M. DeSimone

    Sanjiv Sam Gambhir Professor of Translational Medicine, Professor of Chemical Engineering and, by courtesy, of Chemistry, of Materials Science and Engineering, and of Operations, Information and Technology at the Graduate School of Business

    BioJoseph M. DeSimone is the Sanjiv Sam Gambhir Professor of Translational Medicine and Chemical Engineering at Stanford University. He holds appointments in the Departments of Radiology and Chemical Engineering with courtesy appointments in the Department of Chemistry and in Stanford’s Graduate School of Business.

    The DeSimone laboratory's research efforts are focused on developing innovative, interdisciplinary solutions to complex problems centered around advanced polymer 3D fabrication methods. In Chemical Engineering and Materials Science, the lab is pursuing new capabilities in digital 3D printing, as well as the synthesis of new polymers for use in advanced additive technologies. In Translational Medicine, research is focused on exploiting 3D digital fabrication tools to engineer new vaccine platforms, enhanced drug delivery approaches, and improved medical devices for numerous conditions, with a current major focus in pediatrics. Complementing these research areas, the DeSimone group has a third focus in Entrepreneurship, Digital Transformation, and Manufacturing.

    Before joining Stanford in 2020, DeSimone was a professor of chemistry at the University of North Carolina at Chapel Hill and of chemical engineering at North Carolina State University. He is also Co-founder, Board Chair, and former CEO (2014 - 2019) of the additive manufacturing company, Carbon. DeSimone is responsible for numerous breakthroughs in his career in areas including green chemistry, medical devices, nanomedicine, and 3D printing. He has published over 350 scientific articles and is a named inventor on over 200 issued patents. Additionally, he has mentored 80 students through Ph.D. completion in his career, half of whom are women and members of underrepresented groups in STEM.

    In 2016 DeSimone was recognized by President Barack Obama with the National Medal of Technology and Innovation, the highest U.S. honor for achievement and leadership in advancing technological progress. He has received numerous other major awards in his career, including the U.S. Presidential Green Chemistry Challenge Award (1997); the American Chemical Society Award for Creative Invention (2005); the Lemelson-MIT Prize (2008); the NIH Director’s Pioneer Award (2009); the AAAS Mentor Award (2010); the Heinz Award for Technology, the Economy and Employment (2017); the Wilhelm Exner Medal (2019); the EY Entrepreneur of the Year Award (2019 U.S. Overall National Winner); and the Harvey Prize in Science and Technology (2020). He is one of only 25 individuals elected to all three branches of the U.S. National Academies (Sciences, Medicine, Engineering). DeSimone received his B.S. in Chemistry in 1986 from Ursinus College and his Ph.D. in Chemistry in 1990 from Virginia Tech.

  • Alexander Dunn

    Alexander Dunn

    Associate Professor of Chemical Engineering

    Current Research and Scholarly InterestsMy lab is deeply interested in uncovering the physical principles that underlie the construction of complex, multicellular animal life.

  • Curtis Frank

    Curtis Frank

    W. M. Keck, Sr. Professor in Engineering, Emeritus

    BioThe properties of ultrathin polymer films are often different from their bulk counterparts. We use spin casting, Langmuir-Blodgett deposition, and surface grafting to fabricate ultrathin films in the range of 100 to 1000 Angstroms thick. Macromolecular amphiphiles are examined at the air-water interface by surface pressure, Brewster angle microscopy, and interfacial shear measurements and on solid substrates by atomic force microscopy, FTIR, and ellipsometry. A vapor-deposition-polymerization process has been developed for covalent grafting of poly(amino acids) from solid substrates. FTIR measurements permit study of secondary structures (right and left-handed alpha helices, parallel and anti-parallel beta sheets) as a function of temperature and environment.

    A broadly interdisciplinary collaboration has been established with the Department of Ophthalmology in the Stanford School of Medicine. We have designed and synthesized a fully interpenetrating network of two different hydrogel materials that have properties consistent with application as a substitute for the human cornea: high water swellability up to 85%,tensile strength comparable to the cornea, high glucose permeability comparable to the cornea, and sufficient tear strength to permit suturing. We have developed a technique for surface modification with adhesion peptides that allows binding of collagen and subsequent growth of epithelial cells. Broad questions on the relationships among molecular structure, processing protocol, and biomedical device application are being pursued.

  • Gerald Fuller

    Gerald Fuller

    Fletcher Jones Professor in the School of Engineering
    On Leave from 10/01/2021 To 12/31/2021

    BioThe processing of complex liquids (polymers, suspensions, emulsions, biological fluids) alters their microstructure through orientation and deformation of their constitutive elements. In the case of polymeric liquids, it is of interest to obtain in situ measurements of segmental orientation and optical methods have proven to be an excellent means of acquiring this information. Research in our laboratory has resulted in a number of techniques in optical rheometry such as high-speed polarimetry (birefringence and dichroism) and various microscopy methods (fluorescence, phase contrast, and atomic force microscopy).

    The microstructure of polymeric and other complex materials also cause them to have interesting physical properties and respond to different flow conditions in unusual manners. In our laboratory, we are equipped with instruments that are able to characterize these materials such as shear rheometer, capillary break up extensional rheometer, and 2D extensional rheometer. Then, the response of these materials to different flow conditions can be visualized and analyzed in detail using high speed imaging devices at up to 2,000 frames per second.

    There are numerous processes encountered in nature and industry where the deformation of fluid-fluid interfaces is of central importance. Examples from nature include deformation of the red blood cell in small capillaries, cell division and structure and composition of the tear film. Industrial applications include the processing of emulsions and foams, and the atomization of droplets in ink-jet printing. In our laboratory, fundamental research is in progress to understand the orientation and deformation of monolayers at the molecular level. These experiments employ state of the art optical methods such as polarization modulated dichroism, fluorescence microscopy, and Brewster angle microscopy to obtain in situ measurements of polymer films and small molecule amphiphile monolayers subject to flow. Langmuir troughs are used as the experimental platform so that the thermodynamic state of the monolayers can be systematically controlled. For the first time, well characterized, homogeneous surface flows have been developed, and real time measurements of molecular and microdomain orientation have been obtained. These microstructural experiments are complemented by measurements of the macroscopic, mechanical properties of the films.

  • Xiaojing Gao

    Xiaojing Gao

    Assistant Professor of Chemical Engineering

    BioHow do we design biological systems as “smart medicine” that sense patients’ states, process the information, and respond accordingly? To realize this vision, we will tackle fundamental challenges across different levels of complexity, such as (1) protein components that minimize their crosstalk with human cells and immunogenicity, (2) biomolecular circuits that function robustly in different cells and are easy to deliver, (3) multicellular consortia that communicate through scalable channels, and (4) therapeutic modules that interface with physiological inputs/outputs. Our engineering targets include biomolecules, molecular circuits, viruses, and cells, and our approach combines quantitative experimental analysis with computational simulation. The molecular tools we build will be applied to diverse fields such as neurobiology and cancer therapy.

  • Daniel Herschlag

    Daniel Herschlag

    Professor of Biochemistry and, by courtesy, of Chemical Engineering and of Chemistry

    Current Research and Scholarly InterestsOur research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.

  • Ngan F. Huang

    Ngan F. Huang

    Assistant Professor of Cardiothoracic Surgery (Cardiothoracic Surgery Research) and, by courtesy, of Chemical Engineering

    Current Research and Scholarly InterestsDr. Huang's laboratory aims to understand the chemical and mechanical interactions between extracellular matrix (ECM) proteins and pluripotent stem cells that regulate vascular and myogenic differentiation. The fundamental insights of cell-matrix interactions are applied towards stem cell-based therapies with respect to improving cell survival and regenerative capacity, as well as engineered vascularized tissues for therapeutic transplantation.

  • Thomas Jaramillo

    Thomas Jaramillo

    Associate Professor of Chemical Engineering, of Photon Science and Senior Fellow at the Precourt Institute for Energy

    BioRecent years have seen unprecedented motivation for the emergence of new energy technologies. Global dependence on fossil fuels, however, will persist until alternate technologies can compete economically. We must develop means to produce energy (or energy carriers) from renewable sources and then convert them to work as efficiently and cleanly as possible. Catalysis is energy conversion, and the Jaramillo laboratory focuses on fundamental catalytic processes occurring on solid-state surfaces in both the production and consumption of energy. Chemical-to-electrical and electrical-to-chemical energy conversion are at the core of the research. Nanoparticles, metals, alloys, sulfides, nitrides, carbides, phosphides, oxides, and biomimetic organo-metallic complexes comprise the toolkit of materials that can help change the energy landscape. Tailoring catalyst surfaces to fit the chemistry is our primary challenge.