School of Engineering
Showing 11-20 of 3,170 Results
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Monther Abu-Remaileh
Assistant Professor of Chemical Engineering
Current Research and Scholarly InterestsThe Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. We also study how these pathways go awry in human diseases such as cancer, neurodegeneration and metabolic syndrome, in order to engineer new therapeutic modalities.
To address these questions, our lab uses a multidisciplinary approach to study the biochemical functions of the lysosome in vitro and in vivo. Lysosomes are membrane-bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. Lysosomal function is critical for organismal homeostasis—mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome.
By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. Using insights from our research, we will engineer novel therapies to modulate the pathways that govern human disease. -
James L. Adams
Professor of Industrial Engineering and Engineering Management and of Mechanical Engineering, Emeritus
Current Research and Scholarly InterestsI have for some time been working on two books. The working title for one is Making, Fixing, and Tinkering, and it concerns the benefits of working with the hands. The other has a working title of Homo Demi Sapiens, and is about the balance of creativity and control in very large groups (societies, religions, etc.). I am also revising a book entitled The Building of an Engineer, which I wrote for my aging mother and self-published. It is somewhat autobiographical, and although it is available on Amazon, I do not consider it quite ready for public reading.
