School of Humanities and Sciences
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Associate Professor of ChemistryOn Leave from 09/01/2020 To 12/31/2020
Current Research and Scholarly InterestsOur research centers on problems at the interface of quantum and statistical mechanics. Particular themes that occur frequently in our research are hydrogen bonding, the interplay between structure and dynamics, systems with multiple time and length-scales and quantum mechanical effects. The applications of our methods are diverse, ranging from chemistry to biology to geology and materials science. Particular current interests include proton and electron transfer in fuel cells and enzymatic systems, atmospheric isotope separation and the control of catalytic chemical reactivity using electric fields.
Treatment of these problems requires a range of analytic techniques as well as molecular mechanics and ab initio simulations. We are particularly interested in developing and applying methods based on the path integral formulation of quantum mechanics to include quantum fluctuations such as zero-point energy and tunneling in the dynamics of liquids and glasses. This formalism, in which a quantum mechanical particle is mapped onto a classical "ring polymer," provides an accurate and physically insightful way to calculate reaction rates, diffusion coefficients and spectra in systems containing light atoms. Our work has already provided intriguing insights in systems ranging from diffusion controlled reactions in liquids to the quantum liquid-glass transition as well as introducing methods to perform path integral calculations at near classical computational cost, expanding our ability to treat large-scale condensed phase systems.
David Mulvane Ehrsam and Edward Curtis Franklin Professor in Chemistry and Professor of Photon ScienceOn Leave from 09/01/2020 To 12/31/2020
BioTheoretical chemist Todd Martínez develops and applies new methods that predict and explain how atoms move in molecules. These methods are used both to design new molecules and to understand the behavior of those that already exist. His research group studies the response of molecules to light (photochemistry) and external force (mechanochemistry). Photochemistry is a critical part of human vision, single-molecule spectroscopy, harnessing solar energy (either to make fuels or electricity), and even organic synthesis. Mechanochemistry represents a novel scheme to promote unusual reactions and potentially to create self-healing materials that resist degradation. The underlying tools embody the full gamut of quantum mechanical effects governing molecules, from chemical bond breaking/formation to electron/proton transfer and electronic excited states.
Professor Martínez was born in Amityville, New York, but spent most of his childhood in Central America and the Caribbean. His chemical curiosity benefitted tremendously from the relaxed safety standards in Central American chemical supply houses, giving him unfettered access to strong acids and bases. When he also became interested in computation, limited or nonexistent computer access forced him to write and debug computer programs on paper. Today, Prof. Martínez combines these interests by working toward theoretical and computational modeling and design of molecules. Martínez received his PhD in chemistry from UCLA in 1994. After postdoctoral study at UCLA and the Hebrew University in Jerusalem, he joined the faculty at the University of Illinois in 1996. In 2009, he joined the faculty at Stanford, where he is now the Ehrsam and Franklin Professor of Chemistry and Professor of Photon Science at SLAC National Accelerator Laboratory. He has received numerous awards for his contributions, including a MacArthur Fellowship (commonly known as the “genius award”). He is co-editor of Annual Reviews in Physical Chemistry, associate editor of The Journal of Chemical Physics, and an elected fellow of the American Academy of Arts and Sciences.
Current research in the Martínez lab aims to make molecular modeling both predictive and routine. New approaches to interactive molecular simulation are being developed, in which users interact with a virtual-reality based molecular modeling kit that fully understands quantum mechanics. New techniques to discover heretofore unknown chemical reactions are being developed and tested, exploiting the many efficient methods that the Martínez group has introduced for solving quantum mechanical problems quickly, using a combination of physical/chemical insights and commodity videogaming hardware. For more details, please visit http://mtzweb.stanford.edu.
Susan K. McConnell
Susan B. Ford Professor
Current Research and Scholarly InterestsSusan McConnell has studied the cellular and molecular mechanisms that underlie the development of the mammalian cerebral cortex. Her work focused on the earliest events that pattern the developing forebrain, enable neural progenitors to divide asymmetrically to generate young neurons, propel the migration of postmitotic neurons outward into their final positions, and sculpt the fates and phenotypes of the neurons as they differentiate.
Basic Life Research Scientist
BioChris McFarland is a Postdoctoral Fellow in the Petrov Lab (2014-now). I was a CEGH fellow from 2014-2015 and Cancer Systems Biology Fellow (2015-now). I study cancer using evolutionary modeling. In Leonid Mirny's lab at MIT, I used population genetics modeling and genomic analysis to argue that tumors accumulate many 'deleterious passenger' mutations that are harmful to cancer cells and possibly exploitable by existing and future therapies. I am now working in the Petrov Lab, along with folks in Monte Winslow's lab, to understand how various genetic events combine to induce lung cancer. Intriguingly, we find that the same combinations of genetic events sometimes progresses cells to cancer and sometimes do not. I want to quantitatively describe this variability and understand its origins.
David and Lucile Packard Professor of Marine Science and Senior Fellow at the Woods Institute for the Environment
Current Research and Scholarly InterestsDr Fiorenza Micheli is a marine ecologist and conservation biologist conducting research and teaching at the Hopkins Marine Station of Stanford University. Micheli’s research focuses on the processes shaping marine communities and incorporating this understanding in the management and conservation of marine ecosystems. She is a Pew Fellow, a fellow of the California Academy of Science and the Aldo Leopold Leadership Program, and past president of the Western Society of Naturalists.