School of Medicine
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Sriram Sudarsanam
Postdoctoral Scholar, Neurosurgery
BioSriram is broadly interested in how cellular interactions shape neurodevelopment. He completed his undergraduate studies at the Indian Institute of Science, and Masters at the Weizmann Institute. His doctoral research in Alex Kolodkin’s laboratory at Johns Hopkins addressed the development of idiosyncratic axonal arborization patterns of cortical neurons. He developed genetic strategies to visualize and perturb sparse populations of neurons in the mouse brain, using which he identified novel molecular and cellular determinants of spatially-restricted axon branching in vivo.
Now, as a postdoctoral scholar in Brad Zuchero's laboratory, Sriram is working to develop novel genetic tools to observe and perturb neuron-oligodendrocyte interactions in vivo. In collaboration with Ivan Soltesz’s laboratory, he aims to employ these tools to understand how myelination regulates neural circuit assembly and function. -
Thomas Sudhof
Avram Goldstein Professor in the School of Medicine, Professor of Neurosurgery and, by courtesy, of Neurology and Neurological Sciences and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
