School of Medicine
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Eric Meffre
Professor of Medicine (Immunology and Rheumatology)
BioDr. Meffre obtained his PhD in Immunology from the Université d’Aix-Marseille in France before he moved to the USA as a postdoc fellow in the laboratory of Dr. Michel Nussenzweig at The Rockefeller University in New York City. He became an assistant professor at Cornell University in 2003 before being recruited at Yale University as associate professor in 2009. He was tenured at Yale in 2014 before he joined the Department of Medicine/Division of Immunology and Rheumatology at Stanford University as a tenured full professor in 2022.
Dr. Meffre’s work focuses on the etiology of autoimmune syndromes and the roles played by B cells in these diseases. His group characterized the abnormal selection of developing autoreactive B cells in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), multiple sclerosis (MS) and Sjögren’s syndrome, resulting in large numbers of autoreactive naïve B cells accumulating in the patient’s blood. Hence, these autoreactive B cells may present self-antigens to T cells and initiate autoimmune diseases. These early B cell tolerance defects are likely primary to these autoimmune diseases and may result from genetic factors such as the 1858T PTPN22 allele that segregates with RA, SLE and T1D and correlate with an impaired removal of developing autoreactive B cells.
His research goals also consist in characterizing the molecules and pathways involved in the establishment of B cell tolerance and the removal of developing autoreactive B cells generated by random V(D)J recombination through the investigation of rare patients with primary immunodeficiency (PID) enrolled through an international network. Alteration of B cell receptor (BCR) or Toll-like receptor (TLR) signaling in PID patients results in a defective central B cell tolerance and a failure to counterselect developing autoreactive B cells in the bone marrow. In contrast, functional and suppressive regulatory T cells play a key role in preventing the accumulation of autoreactive clones in the mature naïve B cell compartment. The recent development of humanized mouse models recapitulating early B cell tolerance checkpoints and their defects in autoimmune settings allow further in-depth investigation of tolerance mechanisms and the development of novel approaches to restore defective central and peripheral B cell tolerance checkpoints and thwart autoimmunity. -
Jessica Lee Mega
Affiliate, Medicine - Med/Cardiovascular Medicine
BioJessica L. Mega, MD, MPH is a leader at the intersection of technology, life science, and health. She is a Cardiologist at Stanford and serves on the Advisory Board for Stanford's Center for Digital Health. She is a Co-Founder of Alphabet's Verily and former Chief Medical Officer of Google Life Sciences. She is on the Board of Directors at Boston Scientific, as well as the Board of Advisors for Research!America and the Duke-Margolis Center for Health Policy. She is a Senior Advisor at SandboxAQ and the Chair of the Investment Committee of the American Heart Association’s GRFW Venture Fund.
As a faculty member at Harvard Medical School, a Senior Investigator with the TIMI Study Group, and a Cardiologist at Brigham and Women’s Hospital, Dr. Mega led large, international, randomized trials evaluating novel therapies and new medical technologies. She directed the TIMI Study Group’s Genomics Program, demonstrating and testing the role of CYP2C19 genetic variants on antiplatelet medications, a key pharmacogenetic finding. She has published manuscripts in the New England Journal of Medicine, Lancet, and JAMA. She served as an Advisor for the California Governor’s Precision Medicine Initiative and the Board of Directors at Danaher Corporation.
Dr. Mega is a graduate of Stanford University, Yale University School of Medicine, and Harvard School of Public Health. She completed Internal Medicine Residency at Brigham and Women’s Hospital and Cardiovascular Fellowship at Massachusetts General Hospital. She is board certified in Internal Medicine and Cardiology. She has won the Laennec Society, Samuel A. Levine, and Douglas P. Zipes Awards, and she is a Fellow of the American Heart Association and the American College of Cardiology. -
Uchechukwu Megwalu, MD, MPH
Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsOutcomes Research
Health Disparities
Comparative Effectiveness Research
Health Literacy
Head and Neck Cancer Epidemiology
SEER database analysis -
Thulaj Dattatraya Meharwade
Postdoctoral Scholar, Cardiovascular Institute
BioDr. Thulaj Meharwade is a postdoctoral fellow at the Stanford Cardiovascular Institute with research interests in Inflammaging, disease modeling, cellular heterogeneity and drug discovery. Dr. Meharwade received his PhD in Biochemistry from the University of Montreal, after conducting thesis work on signalling and transcriptional mechanisms regulating cell fate heterogeneity and totipotent stem cells.
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Arnav Mehta, MD, PhD
Adjunct Clinical Assistant Professor, Medicine - Oncology
BioDr. Mehta is a board-certified, fellowship-trained medical oncologist at the Stanford Medicine Cancer Center. He is also an adjunct clinical assistant professor in the gastrointestinal (GI) oncology group of the Department of Medicine, Division of Oncology at Stanford University School of Medicine.
Dr. Mehta specializes in gastrointestinal cancer, with a particular focus on pancreatic and gastric cancers. He also treats colorectal cancers. His treatment specialties include immunotherapy — helping a patient’s immune system fight cancer — and targeted therapies, which send cancer-fighting drugs to specific cancer cell molecules.
His research interests include understanding why GI cancers resist treatments and identifying new ways to treat these tumors. In particular, he is interested in GI tumor immunology, which focuses on directing a person’s immune system to help destroy cancer cells. He also has a special interest in tumor plasticity, which represents the ability of a tumor cell to evolve and develop resistance to therapies.
Dr. Mehta has earned research awards and grants from organizations including the American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO), American Society of Hematology (ASH), and the National Institutes of Health.
Dr. Mehta has published in many peer-reviewed journals, including Nature, Nature Genetics, Nature Immunology, Nature Medicine, Nature Cancer, Cancer Discovery and Immunity. He has written book chapters on subjects including esophageal and gastric cancer. He has also presented his research on topics including tumor immunology and pancreatic cancer at dozens of symposia and meetings around the country.
Dr. Mehta is a member of the AACR and ASCO. -
Jenny Y. Mei
Clinical Assistant Professor, Obstetrics & Gynecology - Maternal Fetal Medicine
Current Research and Scholarly InterestsPostpartum hypertension
Cardio-obstetrics
Quality improvement -
Kara Meister, MD, FAAP, FACS
Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics
BioKara D. Meister, MD, FAAP, FACS is a pediatric otolaryngologist and head & neck surgeon. She received her medical degree from Medical University of South Carolina and completed her otolaryngology residency at University of Pittsburgh. She completed a NIH-funded fellowship in head and neck research at the University of Pittsburgh. Dr. Meister then went on to complete a pediatric otolaryngology fellowship at Lucile Packard Children’s Hospital Stanford.
She is currently an Assistant Professor in the Department Otolaryngology, Division of Pediatric Otolaryngology, at Stanford University. Dr. Meister’s research interests include thyroid cancer, head & neck masses, Graves' disease. She has a special interest in the influence of the environment and pollutants (such as microplastics) on health. She currently serves as the Co-Clinical Chief of Pediatric Otolaryngology. Dr. Meister completed additional training in innovation through the Stanford Biodesign Faculty Fellowship.
Her clinical interests include the treatment of patients with head and neck masses including thyroid nodules and cancer. She is Co-Director, Surgical, of the Children's Thyroid Center at Lucile Packard Children’s Hospital Stanford and is a participating surgeon in the Aerodigestive and Airway Reconstruction Center at Stanford Children’s Health. She is co-editor of the textbook "Pediatric Bronchoscopy for Clinicians" and enjoys advocacy work with the American Academy of Pediatrics Button Battery Taskforce.
Dr. Meister is a member of the American Thyroid Association (ATA) where she serves on the Diversity, Equity, and Inclusion committee and is a member of the ATA Guidelines Writing Group for Thyroid Disease & Pregnancy. She is a member of the pediatric committee of the American Head and Neck Society. She is an author and speaker on masses and tumors of the head and neck, thyroid disease, and thyroid cancer in children and adolescents. In collaboration with SHC, she offers novel treatment for thyroid problems in children and adolescents including radiofrequency ablation of thyroid nodules.
Dr. Meister lives in Woodside with her husband, 3 children, and Rooney the dog.
Clinical Expertise:
Children's Thyroid Center, Co-Director, Surgical
Thyroid nodules
Thyroid cancer - papillary, follicular, and medullary
Surgical management of hyperthyroidism and Grave's disease
MEN syndrome
Head and Neck masses
Congenital neck masses such as branchial cleft cyst, thyroglossal duct cyst
Pediatric Head and Neck cancer
Airway evaluation and reconstruction, voice and swallowing problems, and Aerodigestive
Fetal Airway and Exit Team
