Maternal & Child Health Research Institute (MCHRI)
Showing 1,101-1,120 of 1,214 Results
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Alexander Michael Vezeridis, MD, PhD
Assistant Professor of Radiology (Interventional Radiology)
BioAlexander Vezeridis MD, PhD is an Assistant Professor of Radiology at Stanford University School of Medicine, and a physician-scientist specializing in Interventional Radiology. His clinical expertise includes interventional oncology, biliary disease and endoscopy, venous disease, portal hypertension, urologic interventions, women’s and men’s health interventions, and general vascular/interventional radiology.
Dr. Vezeridis is an active researcher with expertise in translational techniques in engineering to make image-guided interventions safer and more effective for patients.
Dr. Vezeridis obtained his undergraduate, MD, and PhD degrees from Boston University. He completed a two year post-doctoral training at UC San Diego in ultrasound molecular imaging under the auspices of the Cancer Researchers in Nanotechnology (CRIN) R25T, followed by residency and fellowship at UC San Diego.
Dr. Vezeridis is highly committed to training the next generation, including students, residents, fellows, and engineering graduate students through co-directing Bio301B.
Dr. Vezeridis has a strong interest in medical device development and commercialization, and completed the Stanford Biodesign Faculty Fellowship. -
Anne Villeneuve
Berthold and Belle N. Guggenhime Professor and Professor of Developmental Biology and of Genetics
Current Research and Scholarly InterestsMechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.
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Allison Vreeland
Clinical Assistant Professor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
BioDr. Allison Vreeland (she/her) is a licensed clinical psychologist specializing in working with children, teens, and families. Dr. Vreeland received her PhD in Clinical Psychological Science with a minor in Quantitative Studies at Vanderbilt University. She completed her predoctoral clinical internship in Child Psychology at UCSF with specialty training through the Child Trauma Research Program. She completed a research and clinical fellowship in the Immune Behavioral Health Clinic at Stanford University, where she focused her research efforts on examining neurological markers of patients diagnosed with pediatric acute neuropsychiatric syndrome (PANS). Clinically, Dr. Vreeland’s program of clinical care is focused on the delivery of evidence-based clinical interventions for individuals with anxiety, OCD, PANS/PANDAS, mood disorders, and behavioral challenges.
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David Vu
Clinical Associate Professor, Pediatrics - Infectious Diseases
BioDr. Vu is a pediatric infectious diseases specialist who is researching human responses to dengue virus and malaria infections. He performed his undergraduate studies at the University of California, San Diego, and obtained his medical doctorate at the University of Pennsylvania School of Medicine. He trained in general pediatrics at UCSF Benioff Children's Hospital Oakland, and in pediatric infectious diseases at Emory University School of Medicine. His present studies on pediatric dengue and malaria co-infection are supported by an NIAID Career Development Award (K23 AI127909) and a Instructor K Award Support Program Award from the Maternal & Child Health Research Institute and Department of Pediatrics.
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Soichi Wakatsuki
Professor of Photon Science and of Structural Biology
Current Research and Scholarly InterestsUbiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators. -
Claire E Wakefield
Professor of Pediatrics (Quality of Life and Palliative Care)
BioI am a medical psychologist and researcher dedicated to improving quality of life for children affected by serious illness, as well as their families. My research spans pediatric palliative care, precision medicine, psycho-oncology, and global health, and is grounded in a deep commitment to compassionate, patient-centered care. I have published more than 340 journal articles and am named as Chief Investigator on competitive research grants totaling more than $55M.
I served as Continental President of SIOP Oceania and as a Director on the Board of the International Society of Pediatric Oncology (SIOP), advocating for children with cancer across 14 countries. I advise the World Health Organization on global childhood cancer initiatives and am a proud member of the Presidential Task Force on Advocacy for the Society of Pediatric Psychology. I am passionate about building national and global capacity in pediatric palliative care and ensuring that every child and family receives not only the best medical treatment, but also the emotional and psychological support they need. -
Rebecca D. Walker
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly InterestsInterests include international development in emergency care, healthcare disparities, wilderness medicine, human rights, administration
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Dennis Wall
Professor of Pediatrics (Clinical Informatics), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsSystems biology for design of clinical solutions that detect and treat disease
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James Wall
Clinical Professor, Surgery - Pediatric Surgery
Current Research and Scholarly InterestsHealth Technology Innovation
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Brian A. Wandell
Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and of Education
Current Research and Scholarly InterestsModels and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes. Image systems simulations of optics and sensors and image processing. Data and computation management for reproducible research.
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Bing Wang
Postdoctoral Scholar, Stem Cell Transplantation
BioMy academic training and research experience have equipped me with multidisciplinary skills and knowledge of molecular biology and immunology.
I led two projects when I was an undergraduate, in which I got primary academic learning. My team member and I investigated the bacteria content in drinking water from two types of machines that are commonly used in colleges under the guidance of our experimental microbiology teacher Zhihong Zhong. Secondly, we produced a hybridoma cell line secreting monoclonal antibody against the core antigen of the hepatitis C virus (HCV) to develop an ELISA kit for the detection of HCV under the guidance of Dr. Rushi Liu and Minjing Liao.
Thereafter, as a Ph. D. candidate at Xiaoming Feng’s lab, my research primarily focused on understanding the biology of regulatory T cells (Treg) and CD11c+ myeloid cells using cutting-edge single-cell sequencing and conditional knockout mice under healthy and disease conditions. We first revealed the heterogeneity and bifurcated differentiation pathway of human Tregs from normal donors and transplanted patients at the single-cell transcriptome level. A subsequent first and corresponding author publication identified a key innate responsive protein in CD11c+ alveolar macrophages, NRP2, that protects mice from lung injury via promoting the phagocytosis of neutrophils. I also participated in two projects regarding the role of a serine/threonine kinase, LKB1, in mice CD11c+ dendritic cells from lymphoid tissues and adipose tissue with diet-induced obesity. These academic experiences guided me into a strong passion and independent capacities for biomedical studies.
For my postdoctoral training, I will focus on developing Treg therapies and genetic stem cell therapy to cure patients with IPEX syndrome (a severe autoimmune disease) at preclinical and clinical stages, and other immune disorders. My sponsor Dr. Rosa Bacchetta is a well-known leader in treating IPEX patients and developing Treg therapies. My co-mentor Dr. Maria Grazia Roncarolo is a well-recognized pediatric immunologist and also one of the pioneers in the stem cell and gene therapy field, who discovered the type 1 regulatory T cells or Tr1 cells and translate the scientific discoveries into novel Treg therapies. Both of them have an excellent record of training postdoctoral fellows. The proposed projects will provide me with great opportunities in cutting-edge technology and translational research and outline a set of career development including grant writing, public presentation, and lab management, which will enhance my ability to become an independent investigator and help me to reach my goal of developing efficient and safe Treg therapies for a wide range of immune disorders and associated human diseases. -
C. Jason Wang, MD, PhD
LCY: Tan Lan Lee Professor and Professor of Pediatrics (General Pediatrics) and of Health Policy
BioDr. Wang is the Director of Center for Policy, Outcomes and Prevention. Prior to coming to Stanford in 2011, he was a faculty member at Boston University Schools of Medicine and Public Health. His other professional experiences include working as a management consultant with McKinsey and Company and serving as the project manager for Taiwan's National Health Insurance Reform Task-force. His current interests include: 1) pandemic preparedness; 2) role of generative Ai on child health and development; 3) use of mobile technology in improving quality of care; 4) assessing and improving the value of healthcare, and 5) healthcare delivery innovations and payment reforms.
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Li Wang
Assistant Professor of Biology
Current Research and Scholarly InterestsWe study how the extraordinary diversity of cells and synapses in the brain is generated, organized, and maintained, and how these processes are disrupted in diseases such as neurodevelopmental disorders and brain cancer. By combining single-cell and spatial genomics, lineage tracing, perturbation screens, synaptic proteomics, and machine learning models, we aim to uncover the molecular rules that define neural identity and connectivity.
Our research spans two interrelated themes, each grounded in human biology and driven by cutting-edge technologies. By comparing these processes across species, we aim to uncover both conserved mechanisms and human-specific innovations that define the unique features of the human brain. -
Marie Wang
Clinical Professor, Pediatrics
Current Research and Scholarly InterestsEvaluation and management of the febrile young infant and infections in hospitalized children; promotion of appropriate antibiotic use.
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Nancy Ewen Wang
Professor of Emergency Medicine (Pediatrics), Emerita
Current Research and Scholarly Interests- Disparities in Emergency Medical Services for children.
- Efficacy of novel interventions for pediatric access to care.
- Teaching and supporting community-initiated interventions and programs internationally. -
Paul J. Wang, MD
John R. and Ai Giak L. Singleton Director, Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Bioengineering
Current Research and Scholarly InterestsDr. Wang's research centers on the development of innovative approaches to the treatment of arrhythmias, including more effective catheter ablation techniques, more reliable implantable devices, and less invasive treatments. Dr. Wang's clinical research interests include atrial fibrillation, ventricular tachycardia, syncope, and hypertrophic cardiomyopathy. Dr. Wang is committed to addressing disparities in care and is actively involved in increasing diversity in clinical trials.
