Maternal & Child Health Research Institute (MCHRI)
Showing 591-600 of 1,222 Results
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Jeehee Lee
Postdoctoral Scholar, Orthopedic Surgery
BioDr. Lee is a dedicated researcher in the field of biomedical engineering, driven by a strong desire to help individuals suffering from illnesses. With a particular interest in disease treatment and regeneration, she embarked on her journey in this field. During her doctoral studies, Dr. Lee focused on developing functional biomaterials by leveraging chemical bonding at interfaces. Her expertise in this area led her to successfully create functional medical devices. Currently, as a postdoctoral researcher at Stanford University, Dr. Lee is actively involved in drug screening using a bone-mimicking 3D in vitro cancer model that utilizes biomaterials. Her research is centered around the utilization of biomaterials to develop innovative approaches for tuning the communication between cells and biomaterials. By advancing in the field of biomaterials, Dr. Lee aims to facilitate a better understanding of cell-biomaterial interactions, with the ultimate goal of improving healthcare outcomes. With her passion for cutting-edge research and her commitment to the development of biomaterials, Dr. Lee is dedicated to making significant contributions to the field and shaping the future of healthcare.
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Yunkyeong Lee
Postdoctoral Scholar, Endocrinology and Metabolism
BioYun is a postdoctoral research scholar in the Translational Genomics of Diabetes Laboratory under the mentorship of Dr. Anna Gloyn. Since joining the lab in August 2022, she has been investigating type 2 diabetes (T2D) susceptible genes and their molecular mechanisms in pancreatic β-cell dysfunction and the development of T2D. Her primary focus is on how T2D effector transcripts alter autophagy/mitophagy pathways in human pancreatic β-cells, contributing to β-cell failure, mitochondrial dysfunction, and T2D pathology. She also investigated the impact of genetic mutations underlying neonatal diabetes using CRISPR HDR knockin genome editing in human induced pluripotent stem cell (hiPSC) models and their derivatives.
During her PhD, she explored the role of an epigenetic regulator and its molecular machinery in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), now termed metabolic dysfunction-associated steatotic liver disease (MASLD). In parallel, she studied the interplay between endoplasmic reticulum (ER) stress-mediated unfolded protein response (UPR) signalling and autophagy, and examined how these processes are modulated by bioactive plant extracts in various cellular contexts.
She is particularly interested in exploring inter-organ communication, such as pancreas-liver crosstalk, and how these interactions influence systemic metabolism and contribute to the onset and progression of T2D, along with its complications. Her long-term research goal is to advance our understanding of the cellular and molecular mechanisms driving T2D and to identify novel therapeutic targets and strategies. -
Christopher Lee-Messer, MD, PhD
Clinical Associate Professor, Pediatric Neurology
Clinical Associate Professor (By courtesy), PediatricsCurrent Research and Scholarly InterestsMy chief clinical focus is in pediatric epilepsy, especially how epilepsy affects learning and development. For my research, I background in neural development and computational neuroscience towards developing better learning algorithms and applying the latest techniques in machine learning for better diagnosis and treatment of disease.
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John Leikauf
Clinical Associate Professor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
Current Research and Scholarly InterestsI am interested in better understanding the heterogeneous cognitive and electrophysiological abnormalities in children with ADHD and the many other conditions that commonly co-occur with ADHD. The long-term goal is to be able to better target treatments to specific deficits in order to promote long-term health and well-being and improve outcomes that matter to individuals and families suffering from these disorders.
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Mary Leonard
Arline and Pete Harman Professor, Professor of Pediatrics (Nephrology), of Medicine (Nephrology) and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsMy multidisciplinary research program is focused on (1) the detrimental effects of glucocorticoids, sarcopenia and inflammation on bone development in pediatric diseases, (2) the long-term effects of childhood cancer on bone and muscle quality, (3) the assessment of renal osteodystrophy using novel micro-imaging techniques, (4) the effects of vitamin D deficiency on physical function and cardiovascular disease, and (5) the evaluation of biomechanical interventions as anabolic bone therapies.
