School of Medicine
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Postdoctoral Research Fellow, Genetics
Current Research and Scholarly InterestsMy research aims to develop efficient computational approaches for constructing meaningful networks using multi-omics data. The rapid development of sequencing technologies produces a lot of multi-omics data. We could construct much more stable and accurate biological networks from these multi-omics data than only one-omic data. Then we can make further analysis on the association between networks and diseases from the system views.
Postdoctoral Research Fellow, Cardiovascular Medicine
BioMy long-term goal is to investigate the functional genomics of rare and common variants that cause metabolic and cardiovascular comorbidity. In particular, I am interested in the genetics of insulin resistance as major underlying risk factor for cardiometabolic diseases.
After completing my master’s degree, I was attracted by the hypothesis that early onset coronary artery disease (CAD) is a genetic subtype of the common type of CAD. In collaboration with Dr. Arya Mani, an expert in Mendelian forms of CAD (Yale University), and Prof Reza Malekzadeh, a pioneer of cohort studies (Tehran University), and HHMI investigator in Yale University, Dr. Richard Lifton, I contributed to the genetic analysis of families with early onset CAD and metabolic syndrome. We identified DYRK1B as a causative gene (co-first author; N Engl J Med; 2014).
During my PhD thesis, I worked on exome data of Mendelian/monogenic disorders that have been sequenced at Yale Genome center to filter them for rare and pathogenic variants. Also, I used RNA-Seq to sequence the transcriptome of human skeletal muscle biopsies from the carriers and non-carriers of the DYRK1B mutation. I also applied LFQ-MS (label free quantification- tandem mass spectrometry) to address changes in the proteome of DYRK1B mutants in both human muscle biopsies and in vitro models. Through these studies I gained an experimental and conceptual framework for high-throughput data analyses focusing on the networks of metabolic pathways for insulin resistance.
I am enthusiastic to pursue functional genomic characterization of genes found through GWAS of Insulin Resistance with fantastic group of investigators at Stanford medicine.
Postdoctoral Research Fellow, Molecular and Cellular Physiology
BioI am a Postdoc in Dr. Goodman’s lab. Here we investigate (mechano-) sensation of the nematode C. elegans. I am especially interested in the touch response and in the chemo-sensation learning behavior. For these studies I use:
- Fluorescence microscopy
- Microfluidic chips
- Calcium imaging
- Image and data analysis with ImageJ and Python
Before coming to Stanford I did my Ph.D. at the University of Cologne, Germany. For this I did my doctoral research at Prof. Kaupp’s lab at the research center caesar in Bonn, Germany. The title of my thesis is: "Single-molecule studies of the ligand binding of a hyperpolarization-activated and cyclic nucleotide-gated ion channel". For these studies I used:
- Fluorescence, single-molecule microscopy (TIRF)
- Image analysis with ImageJ
- Fluorescence lifetime spectroscopy
Before starting my doctoral research I studied physics, with focus on optics, at the Leibniz University Hannover, Germany. I did my diploma at Prof. Heisterkamp’s lab at the Laser Center Hannover, Germany. The title of my thesis is: "Plasmonic-based laser transfection". For these studies I used:
- fs laser pulses
- Plasmonics at gold nanoparticels
- Two-photon microscopy