School of Medicine

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  • Huaying Fang

    Huaying Fang

    Postdoctoral Research Fellow, Genetics

    Current Research and Scholarly InterestsMy research aims to develop efficient computational approaches for constructing meaningful networks using multi-omics data. The rapid development of sequencing technologies produces a lot of multi-omics data. We could construct much more stable and accurate biological networks from these multi-omics data than only one-omic data. Then we can make further analysis on the association between networks and diseases from the system views.

  • Mohsen Fathzadeh

    Mohsen Fathzadeh

    Postdoctoral Research Fellow, Cardiovascular Medicine

    BioMy long-term goal is to investigate the functional genomics of rare and common variants that cause metabolic and cardiovascular comorbidity. In particular, I am interested in the genetics of insulin resistance as major underlying risk factor for cardiometabolic diseases.
    After completing my master’s degree, I was attracted by the hypothesis that early onset coronary artery disease (CAD) is a genetic subtype of the common type of CAD. In collaboration with Dr. Arya Mani, an expert in Mendelian forms of CAD (Yale University), and Prof Reza Malekzadeh, a pioneer of cohort studies (Tehran University), and HHMI investigator in Yale University, Dr. Richard Lifton, I contributed to the genetic analysis of families with early onset CAD and metabolic syndrome. We identified DYRK1B as a causative gene (co-first author; N Engl J Med; 2014).
    During my PhD thesis, I worked on exome data of Mendelian/monogenic disorders that have been sequenced at Yale Genome center to filter them for rare and pathogenic variants. Also, I used RNA-Seq to sequence the transcriptome of human skeletal muscle biopsies from the carriers and non-carriers of the DYRK1B mutation. I also applied LFQ-MS (label free quantification- tandem mass spectrometry) to address changes in the proteome of DYRK1B mutants in both human muscle biopsies and in vitro models. Through these studies I gained an experimental and conceptual framework for high-throughput data analyses focusing on the networks of metabolic pathways for insulin resistance.
    I am enthusiastic to pursue functional genomic characterization of genes found through GWAS of Insulin Resistance with fantastic group of investigators at Stanford medicine.

  • Holger Fehlauer

    Holger Fehlauer

    Postdoctoral Research Fellow, Molecular and Cellular Physiology

    BioI am a Postdoc in Dr. Goodman’s lab. Here we investigate (mechano-) sensation of the nematode C. elegans. I am especially interested in the touch response and in the chemo-sensation learning behavior. For these studies I use:
    - Fluorescence microscopy
    - Microfluidic chips
    - Calcium imaging
    - Image and data analysis with ImageJ and Python

    Before coming to Stanford I did my Ph.D. at the University of Cologne, Germany. For this I did my doctoral research at Prof. Kaupp’s lab at the research center caesar in Bonn, Germany. The title of my thesis is: "Single-molecule studies of the ligand binding of a hyperpolarization-activated and cyclic nucleotide-gated ion channel". For these studies I used:
    - Fluorescence, single-molecule microscopy (TIRF)
    - Image analysis with ImageJ
    - Electrophysiology
    - Fluorescence lifetime spectroscopy

    Before starting my doctoral research I studied physics, with focus on optics, at the Leibniz University Hannover, Germany. I did my diploma at Prof. Heisterkamp’s lab at the Laser Center Hannover, Germany. The title of my thesis is: "Plasmonic-based laser transfection". For these studies I used:
    - fs laser pulses
    - Plasmonics at gold nanoparticels
    - Two-photon microscopy