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Seunghee Lee

Postdoctoral Scholar, Pulmonary and Critical Care Medicine

Contact Info
Mail Code: 5236
seunghee@stanford.edu

BioYun is a postdoctoral research scholar in Dr Anna Gloyn lab (Translational Genomics of Diabetes Lab). Since she joined the lab in August 2022, she has been involved in projects investigating type 2 diabetes (T2D) susceptible genes and their molecular mechanisms for pancreatic beta-cell dysfunction under the mentorship of Dr Gloyn. In particular, she is focusing on how T2D effector transcripts alter the autophagy/mitophagy pathways in human pancreatic beta-cells and how this may lead to beta-cell failure, mitochondrial dysfunction and T2D pathology. She has been also digging into genetic mutations which are a cause of neonatal diabetes using CRISPR genome editing technique in human induced pluripotent stem cell (hiPSC) line.
During her PhD, she focused on the roles of an epigenetic regulator and its molecular machineries in the pathogenesis of non-alcoholic fatty liver disease (NAFLD)/now metabolic dysfunction-associated steatotic liver disease (MASLD). Besides, she studied the correlation between endoplasmic reticulum (ER) stress-mediated unfolded protein response (UPR) signalling and autophagy, and further their effects on various cells using some plant extracts. Her research goal is to expand our knowledge about the cellular and molecular mechanisms of T2D and explore therapeutic targets and/or strategies.