School of Medicine
Showing 21-36 of 36 Results
Wallenberg-Bienenstock Professor and Professor of Bioengineering and of Microbiology and Immunology
Current Research and Scholarly InterestsMy research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.
Professor of Pediatrics (Neonatology) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine)
Current Research and Scholarly InterestsNeurological monitoring in critically ill infants. Altered hemodynamics in neonates, especially in relation to prematurity, congenital heart disease, and central nervous system injury. Determination of the hemodynamic significance and effects of a patent ductus arteriosus in the preterm infant. Utilizing NIRS (near-infrared spectroscopy) and other technologies for improved monitoring in the NICU.
Danny Hung-Chieh Chou
Assistant Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
Daniel Eugene Clark
Clinical Assistant Professor, Medicine - Cardiovascular Medicine
Clinical Assistant Professor, Pediatrics - Cardiology
BioDr. Clark completed a 4-year MD/MPH program at the University of Texas Health Science Center in San Antonio. He subsequently completed all of his post-graduate training at Vanderbilt University Medical Center (VUMC), including Internal Medicine-Pediatrics, Adult Cardiology, and Adult Congenital Heart Disease (ACHD). Additionally, he served as Chief Fellow of the Vanderbilt Cardiovascular Medicine Fellowship, trained in multimodality cardiovascular imaging, and conducted clinical research during a two-year NIH-funded T32 research fellowship at VUMC.
Prior to joining the Stanford ACHD faculty, he was appointed Instructor of Cardiovascular Medicine at Vanderbilt and read cardiac magnetic resonance (CMR) imaging as an attending for two years. He is appointed Assistant Professor of Medicine and Pediatrics at Stanford University School of Medicine.
His academic and investigative interests focus on advanced cardiovascular imaging for ACHD patients, particularly the application of CMR in this population. During the COVID-19 pandemic, Dr. Clark pivoted his scholarly efforts to focus on studying the cardiovascular effects of COVID-19 with CMR. His current clinical investigations include understanding the CMR-derived diastolic patterns of Fontan physiology and the effect of cardiac rehabilitation on functional status among patients with Fontan failure.
Shoa L. Clarke, MD, PhD
Assistant Professor of Medicine (Cardiovascular Medicine) and of Pediatrics
BioDr. Clarke is a preventive cardiologist and a physician-scientist focused on disease prevention. He earned his undergraduate degree in human biology from the Division of Nutritional Sciences at Cornell University before obtaining his MD and PhD (genetics) from Stanford University School of Medicine. He has completed clinical training in internal medicine (Brigham & Women’s Hospital), pediatrics (Boston Children’s Hospital), and cardiovascular medicine (Stanford Hospital), and he is board certified in all three specialties. His research is focused on 1) understanding complex disease genetics in diverse populations, 2) integrating monogenic and polygenic risk with clinical risk, 3) large-scale phenotyping using the electronic health record and medical images. His clinical practice focuses on identifying risk factors for cardiovascular disease with the goal of promoting health and longevity through evidence-based personalized treatment. He is interested in developing family-centric approaches for the treatment of adults and children carrying genetic risk for disease.
William Clusin, MD
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsCardiac action potentials; tissue culture, voltage, clamp technique; role of calcium in ischemia arrhythmias; coronary, artery disease; myocardial infarction.
Jennifer R. Cochran
Senior Associate Vice Provost for Research, Addie and Al Macovski Professor, Professor of Bioengineering and, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsMolecular Engineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology
Associate Professor of Pediatrics (Pulmonary Medicine)On Leave from 08/01/2023 To 12/31/2023
Current Research and Scholarly InterestsI am interested in studying the effects of inflammation in the lung, in particular, how N-acetylcysteine may affect and decrease that in CF patients. I am the PI of a multi-center study researching this question. Additionally, in a separate study involving children who have received lung transplants, I am a participating site in an NIH-sponsored observational and mechanistic multi-center study that will examine the role of viral infections in causing chronic graft rejection.
Christopher H. Contag
Professor of Pediatrics (Neonatology), Emeritus
Current Research and Scholarly InterestsWe develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.
John P. Cooke, MD, PhD
Professor of Medicine (Cardiovascular Medicine), Emeritus
Current Research and Scholarly InterestsOur translational research program in vascular regeneration is focused on generating and characterizing vascular cells from human induced pluripotential stem cells. We are also studying the therapeutic application of these cells in murine models of peripheral arterial disease. In these studies we leverage our longstanding interest in endothelial signaling, eg by nitric oxide synthase (NOS) as well as by nicotinic cholinergic receptors (nAChR).
David N. Cornfield
Anne T. and Robert M. Bass Professor of Pediatric Pulmonary Medicine and Professor, by courtesy, of Surgery
Current Research and Scholarly InterestsOver the past 20 years, the Cornfield Laboratory has focused upon basic, translational and clinical research, with a primary focus on lung biology. As an active clinician-scientist, delivering care to acutely and chronically ill infants and children, our lab focuses on significant clinical challenges and tried to use science to craft novel solutions to difficult clinical problems.
Shriram Chair of the Department of Bioengineering, Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors.
David Korn, MD, Professor of Pathology and Professor of Developmental Biology
Current Research and Scholarly InterestsChromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin and epigenetic regulation in living cells.
Job and Gertrud Tamaki Professor of Chemistry
Current Research and Scholarly InterestsOur objective is to develop new biophysical methods to advance current understandings of cellular machinery in the complicated environment of living cells. Currently, we are focusing on four research areas: (1) Membrane curvature at the nano-bio interface; (2) Nanoelectrode arrays (NEAs) for scalable intracellular electrophysiology; (3) Electrochromic optical recording (ECORE) for neuroscience; and (4) Optical control of neurotrophin receptor tyrosine kinases.
Maria Elizabeth Currie, MD, PhD
Clinical Assistant Professor, Cardiothoracic Surgery
BioDr. Currie is a board-certified, fellowship-trained cardiothoracic surgeon. She is also a clinical assistant professor at Stanford University School of Medicine. With subspecialty training in heart failure, Dr. Currie treats all forms of cardiomyopathy, ischemic heart disease, and valvular heart disease. She performs heart transplant, lung transplant, and combined heart-lung transplant procedures as part of a multidisciplinary team. She excels at valve surgery and the implantation of mechanical circulatory support systems.
Dr. Currie welcomes referrals from cardiologists and primary care physicians as early as possible when cardiovascular disease is suspected. Understanding that early intervention can prevent later complications, she invites communication about screening, diagnostics, and treatment strategies.
For each patient, Dr. Currie’s goal is to achieve the best possible outcome using the most advanced minimally invasive cardiac care techniques and technology available. Combined with technical expertise and a focus on excellent clinical outcomes, Dr. Currie delivers empathetic, thoughtful patient care. She ensures that patients are well informed about what they can expect both before and after their surgical procedure.
Dr. Currie is passionate about improving the safety of cardiac surgery. Her research includes translational studies on new ways to visualize anatomic structures that are difficult to see during minimally invasive surgery. One published study investigated the use of augmented reality (AR) guided by transesophageal echocardiography in minimally invasive mitral valve repair. Her work has appeared in The Journal of Thoracic and Cardiovascular Surgery, The Annals of Thoracic Surgery, The International Journal of Medical Robotics and Computer Assisted Surgery, Transplant Immunology, and other peer reviewed publications.
Dr. Currie’s interest in technological advances is rooted in her commitment to the evolution of technology and technique in the fast-changing, relatively young field of cardiac surgery. Also driving her interest is her PhD background in biomedical engineering. She has made presentations on the use of AR systems, 3D visualization technology, and robotics-assisted surgical procedures at the American Association for Thoracic Surgery Annual Meeting, International Society for Minimally Invasive Surgery Annual Scientific Meeting, and other conferences.
Dr. Currie has won numerous awards for her research achievements and scholarship. She is a Fellow of the Royal College of Surgeons of Canada. She is also a member of The Society of Thoracic Surgeons, the International Society for Heart and Lung Transplantation, the International Society for Minimally Invasive Cardiothoracic Surgery, Women in Thoracic Surgery, and the Association of Women Surgeons. With its long legacy of leadership in cardiac surgery and research, Dr. Currie feels Stanford Health Care enables her to pursue her research interests and offers her patients access to the latest innovations, along with expertise across specialties including engineering and statistics.
Martha S. Cyert
Dr. Nancy Chang Professor
Current Research and Scholarly InterestsThe Cyert lab is identifying signaling networks for calcineurin, the conserved Ca2+/calmodulin-dependent phosphatase, and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin’s many physiological functions. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied.