School of Medicine
Showing 821-830 of 924 Results
-
Steven M. Corsello
Assistant Professor of Medicine (Oncology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur laboratory operates at the intersection of functional genomics and chemical biology, with the goal of advancing novel molecular mechanisms of cancer inhibition to clinical use. We aim to 1) leverage phenotypic screening and functional genomics to determine novel anti-cancer mechanisms of small molecules, 2) develop new targeted therapy approaches against solid tumors, and 3) build a comprehensive community resource for drug repurposing discovery.
-
Ximena Corso Díaz
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsWe are interested in unraveling the roles of RNA-binding proteins (RBPs) and regulatory RNAs in retinal development and homeostasis.
RNA-binding proteins mediate functional integration of transcriptional and post-transcriptional machineries influencing various aspects of gene expression and RNA metabolism. Several RBPs have cell-type enriched expression patterns in the retina or cause blinding diseases, however their role in retinal development and function is poorly understood. We have identified several RBPs that interact with the photoreceptor-specific transcription factor NRL and are likely involved in development and homeostasis of this retinal cell-type. We are pursuing the following lines of research:
1) RBPs in retinal development and degeneration. We will study the role of RBPs in regulating retinal development and maintaining homeostasis. We will focus on RBPs enriched in the retina, their interactions with retinal transcription factors like NRL, and their relevance to retinal diseases.
2) RBPs in R-loop regulation in the retina. R-loops are triple-stranded structures created when RNA anneals to one of the strands of the DNA duplex. R-loops have many regulatory roles during gene expression and their dysregulation can be detrimental to genome integrity. We observed that R-loops are dynamic during retinal development and identified key R-loop-associated RBPs that are enriched in rod photoreceptors and that interact with the transcription factor NRL. We will study the role of R-loops and their regulatory RBPs in retinal development and homeostasis.
3) Chromatin-associated regulatory RNAs through the retina lifespan. Chromatin-associated RNAs contribute to the dynamic regulation of gene expression, chromatin structure, and genome organization, playing essential roles in various biological processes, including development, differentiation, and disease. We will study how regulatory RNAs, together with their cognate RBPs, influence expression programs and chromatin dynamics through the retina lifespan. -
Angela Corvino
Postdoctoral Scholar, General Surgery
Current Research and Scholarly InterestsPostdoctoral researcher pioneering the advancement of novel radiotherapy approaches (FLASH, SFRT) to tackle a critical challenge: minimising damage to healthy tissue surrounding difficult to treat tumors. I'm hands-on in all stages of preclinical experimentation, spanning from Monte Carlo simulations for planning and precise dosimetry, to conducting small animal irradiation, follow-ups, and insightful data analysis.
-
Jennifer Cory
Director of Strategy and Operations, Peds/CDCM Center for Definitive and Curative Medicine
Current Role at StanfordDirector of Strategy and Operations, Center for Definitive and Curative Medicine
-
Zaria Cosby, MPH
Social Science Research Professional 2, Stanford-Surgery Policy Improvement Research and Education Center
BioZaria Cosby, BS, MPH, is a Social Science Research Professional at the S-SPIRE Center. She completed her Master of Public Health with a concentration in Biostatistics and Epidemiology, as well as her Bachelor of Science in Health Promotion and Disease Prevention, at the University of Southern California. During her time at USC, Zaria worked on multiple projects across a variety of topics, the most recent being her master’s capstone: a mixed-methods study into the lived experiences of women of color with HIV during the Covid pandemic. At S-SPIRE, she supports qualitative and quantitative data collection, analysis, and interpretation. Zaria also holds a Certified Personal Trainer certification from the National Academy of Sports Medicine. No matter the position or project, Zaria’s overarching goal is to help people become their healthiest selves through research and education.
