School of Medicine
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Professor of Cardiothoracic Surgery (Adult Cardiac Surgery) at the Stanford University Medical Center
Current Research and Scholarly InterestsCardiac surgery education and simulation-based learning, coronary artery bypass surgery, cardiac valve disease, thoracic aortic disease
William Fearon, MD
Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly InterestsDr. Fearon's general research interest is coronary physiology. In particular, he is investigating invasive methods for evaluating the coronary microcirculation. His research is currently funded by an NIH R01 Award.
Jeffrey A. Feinstein, MD, MPH
Dunlevie Family Professor of Pulmonary Vascular Disease and Professor, by courts, of Bioengineering at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly InterestsResearch interests include (1) computer simulation and modeling of cardiovascular physiology with specific attention paid to congenital heart disease and its treatment, (2) the evaluation and treatment of pulmonary hypertension/pulmonary vascular diseases, and (3) development and testing of medical devices/therapies for the treatment of congenital heart disease and pulmonary vascular diseases.
Assistant Professor of Pediatrics (Endocrinology)
Current Research and Scholarly InterestsThe overall goal of our research is to understand on both a molecular and systemic level how hormones regulate stem cell fate decisions and the role these pathways play in both physiology and disease. We use molecular biology and in vivo models to elucidate mechanisms of regulating cell fate determination by the endocrine system. Understanding these processes has profound and broad implications for both science and health.
Michael Fischbein, MD, PhD
Associate Professor of Cardiothoracic Surgery (Adult Cardiac Surgery) at the Stanford University Medical Center
Current Research and Scholarly InterestsMolecular and genetic mechanisms of aortic aneurysm/dissection development. Molecular mechanisms of aneurysm formation in Marfan Syndrome. Clinical research interests include thoracic aortic diseases (aneurysms, dissections).
Professor of Radiology (General Radiology) at the Stanford University Medical Center
Current Research and Scholarly InterestsNon-invasive Cardiovascular Imaging
Contrast Medium Dynamics
Michael B. Fowler, MB, FRCP
Professor of Medicine (Cardiovascular) at the Stanford University Medical Center
Current Research and Scholarly InterestsAdrenergic nervous system; beta-adrenergic function in, heart failure; drugs in heart failure.
W. M. Keck, Sr. Professor in Engineering and Professor, by court, of Materials Science and Engineering
BioThe properties of ultrathin polymer films are often different from their bulk counterparts. We use spin casting, Langmuir-Blodgett deposition, and surface grafting to fabricate ultrathin films in the range of 100 to 1000 Angstroms thick. Macromolecular amphiphiles are examined at the air-water interface by surface pressure, Brewster angle microscopy, and interfacial shear measurements and on solid substrates by atomic force microscopy, FTIR, and ellipsometry. A vapor-deposition-polymerization process has been developed for covalent grafting of poly(amino acids) from solid substrates. FTIR measurements permit study of secondary structures (right and left-handed alpha helices, parallel and anti-parallel beta sheets) as a function of temperature and environment.
A broadly interdisciplinary collaboration has been established with the Department of Ophthalmology in the Stanford School of Medicine. We have designed and synthesized a fully interpenetrating network of two different hydrogel materials that have properties consistent with application as a substitute for the human cornea: high water swellability up to 85%,tensile strength comparable to the cornea, high glucose permeability comparable to the cornea, and sufficient tear strength to permit suturing. We have developed a technique for surface modification with adhesion peptides that allows binding of collagen and subsequent growth of epithelial cells. Broad questions on the relationships among molecular structure, processing protocol, and biomedical device application are being pursued.