School of Medicine
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Paul George, MD, PhD
Assistant Professor of Neurology and, by courtesy, of Neurosurgery at the Stanford University Medical CenterOn Partial Leave from 12/01/2020 To 05/31/2021
Current Research and Scholarly InterestsCONDUCTIVE POLYMER SCAFFOLDS FOR STEM CELL-ENHANCED STROKE RECOVERY:
We focus on developing conductive polymers for stem cell applications. We have created a microfabricated, polymeric system that can continuously interact with its biological environment. This interactive polymer platform allows modifications of the recovery environment to determine essential repair mechanisms. Recent work studies the effect of electrical stimulation on neural stem cells seeded on the conductive scaffold and the pathways by which it enhances stroke recovery Further understanding the combined effect of electrical stimulation and stem cells in augmenting neural repair for clinical translational is a major focus of this research going forward.
BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for stroke and neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration and stroke recovery. Recent work utilizing these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes.
Clinical Professor, Neurosurgery
Current Research and Scholarly InterestsPrincipal Investigator,
“Concussion Definition Consortium – An Evidence Based Project”. Department of Defense. There are over 40 definitions of concussion but none are evidence based- i.e. come from well done studies. We will extract the most salient data from well run studies that are designed to give us a "snapshot" of what concussion is.
“Multi-Dimensional Model for Brain Trauma”. The goal is to develop a dynamic model for concussion, validate it on a retrospective dataset, and design a second study to validate it on a prospective dataset. Department of Defense.
“EYE-TRAC Advance”. Testing 10,000 subjects with normal and post concussive eye tracking. Military and civilian athletes are included. Department of Defense.
B-TEC (Brain Trauma Evidence-based Consortium). Combines Stanford B-TEC clinical trials coordinating center with the Brain Trauma Foundation's B-TEC evidence-based center to promote and coordinate an evidence-based approach to the spectrum of brain trauma from concussion to coma.
Iris C. Gibbs, MD, FACR, FASTRO
Professor of Radiation Oncology (Radiation Therapy) and, by courtesy, of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly InterestsDr. Gibbs is a board-certified radiation oncologist who specializes in the treatment of CNS tumors. Her research focuses on developing new radiation techniques to manage brain and spinal tumors in adults and children. Dr. Gibbs has gained worldwide acclaim for her expertise in Cyberknife robotic radiosurgery.
Gerald Grant, MD, FACS
Endowed Professor in Pediatric Neurosurgery, Botha Chan Endowed Professor and Professor, by courtesy, of Neurology at the Stanford University Medical Center
Current Research and Scholarly InterestsDr. Grant directs a Blood-brain Barrier Translational Laboratory focusing on enhancing drug delivery to brain tumors in children.