School of Medicine
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Sharada Kalanidhi
Director of Data Science, Biochemistry - Genome Center
Current Role at StanfordSharada is focused on building a Data Science capability at SGTC. Her recent research has involved multivariate and machine learning analysis of the biological mechanisms underlying ME/CFS and post-viral fatigue. Her previous research involved non-parametric analysis of the use of Aripiprazole as a treatment for ME/CFS.
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Danish Khan
Postdoctoral Scholar, Biochemistry
BioDanish is an accomplished researcher who has been working as a postdoctoral research associate at Prof. Onn Brandman's Lab at the Department of Biochemistry for approximately 3.5 years. His primary area of research revolves around unraveling the intricate mechanisms of eukaryotic protein quality control and stress response pathways. Danish's scientific journey at Stanford began as a post-doc under the supervision of Prof. Georgios Skiniotis where he worked for less than a year. He joined the Brandman Lab, motivated by his strong interest in investigating ribosome-associated quality control (RQC) pathways and the fascinating phenomenon of "CAT tails," which involves the addition of amino acids to a protein without an mRNA template.
Motivated by a desire to comprehend how defects in RQC pathways contribute to the development of neurodegenerative diseases in humans, Danish aspires to develop therapeutic interventions for these conditions. Within the Brandman lab, Danish has achieved a notable accomplishment, co-authoring a second author paper in the prestigious eLife journal. The publication showcases the establishment of a groundbreaking reverse genetic screen method called ReporterSeq. Currently, Danish is diligently working on two manuscripts that disclose novel and groundbreaking findings concerning the determinants and consequences of CAT tails.
Prior to his time at Stanford, Danish successfully earned his PhD from Texas A&M University in College Station, TX. During his doctoral studies, he delved into the chemical inhibition of a lipid signaling protein, leading to the discovery of a remarkable heme-binding lipid transfer protein. Danish's exceptional work during his graduate school tenure resulted in the publication of three first-author papers in renowned journals such as eLife, Cell Chemical Biology, and the Journal of Lipid Research. Additionally, he made valuable contributions as a middle author to four additional papers.
Danish's academic journey commenced with a Bachelor's degree in Biochemistry from Presidency College, Kolkata (University of Calcutta), India. He then obtained his Master's degree in Biotechnology from Banaras Hindu University in India. Outside of his scientific pursuits, Danish harbors an interest in law and the intersection between law and technology, often immersing himself in related literature. -
Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Peter S. Kim
Virginia and D. K. Ludwig Professor of Biochemistry
On Partial Leave from 09/01/2023 To 06/30/2024Current Research and Scholarly InterestsWe are studying the mechanism of viral membrane fusion and its inhibition by drugs and antibodies. We use the HIV envelope protein (gp120/gp41) as a model system. Some of our studies are aimed at creating an HIV vaccine. We are also characterizing protein surfaces that are referred to as "non-druggable". These surfaces are defined empirically based on failure to identify small, drug-like molecules that bind to them with high affinity and specificity.
