School of Medicine


Showing 1-10 of 98 Results

  • I Lehman

    I Lehman

    William M. Hume Professor in the School of Medicine, Emeritus

    Current Research and Scholarly InterestsWe study Herpes simplex virus type 1 as a model eukaryotic chromosome for the analysis of eukaryotic DNA replication and recombination

  • Steven Artandi

    Steven Artandi

    Jerome and Daisy Low Gilbert Professor and Professor of Biochemistry

    Current Research and Scholarly InterestsTelomeres are nucleoprotein complexes that protect chromosome ends and shorten with cell division and aging. We are interested in how telomere shortening influences cancer, stem cell function, aging and human disease. Telomerase is a reverse transcriptase that synthesizes telomere repeats and is expressed in stem cells and in cancer. We have found that telomerase also regulates stem cells and we are pursuing the function of telomerase through diverse genetic and biochemical approaches.

  • Suzanne Pfeffer

    Suzanne Pfeffer

    Emma Pfeiffer Merner Professor in the Medical Sciences

    Current Research and Scholarly InterestsThe goal of our research is to elucidate the molecular mechanisms by which proteins and cholesterol are transported between specific membrane compartments. We are trying to understand how phosphorylation of Rabs may trigger Parkinson's Disease. We also study how cells acquire cholesterol from the diet and from LDL; cholesterol export from lysosomes is critical for normal cell function.

  • RonaldĀ W. Davis

    RonaldĀ W. Davis

    Professor of Biochemistry and of Genetics

    Current Research and Scholarly InterestsWe are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.

  • Mark Krasnow

    Mark Krasnow

    Professor of Biochemistry

    Current Research and Scholarly Interests- Lung development and stem cells
    - Neural circuit of breathing
    - Lung diseases including lung cancer
    - New genetic model organisms for medicine

  • Gilbert Chu

    Gilbert Chu

    Professor of Medicine (Oncology) and of Biochemistry

    Current Research and Scholarly InterestsOur laboratory seeks to understand how cells repair DNA damage. We currently focus on how non-homologous end joining proteins assemble on DNA ends to juxtapose them for repair of DNA double-strand breaks.

    We are collaborating in the development of a point-of-care device to measure ammonia from a drop of blood. The device will facilitate diagnosis and management of urea cycle defects, liver disease, and chemobrain due to elevated ammonia.

  • Daniel Herschlag

    Daniel Herschlag

    Professor of Biochemistry and, by courtesy, of Chemical Engineering and of Chemistry

    Current Research and Scholarly InterestsOur research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.

  • Patrick O. Brown

    Patrick O. Brown

    Professor of Biochemistry, Emeritus

    Current Research and Scholarly InterestsDr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program. The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.

  • Julie Theriot

    Julie Theriot

    Professor of Biochemistry and of Microbiology and Immunology

    Current Research and Scholarly InterestsWe study the interactions between infectious bacteria and the human host cell actin cytoskeleton. Listeria monocytogenes and Shigella flexneri are unrelated food-borne bacterial pathogens that share a common mechanism of invasion and actin-dependent intercellular spread in epithelial cells. Our studies fall into three broad areas: the biochemical basis of actin-based motility by these bacteria, the biophysical mechanism of force generation, and the evolutionary origin of pathogenesis.

  • Pehr Harbury

    Pehr Harbury

    Associate Professor of Biochemistry

    Current Research and Scholarly InterestsScientific breakthroughs often come on the heels of technological advances; advances that expose hidden truths of nature, and provide tools for engineering the world around us. Examples include the telescope (heliocentrism), the Michelson interferometer (relativity) and recombinant DNA (molecular evolution). Our lab explores innovative experimental approaches to problems in molecular biochemistry, focusing on technologies with the potential for broad impact.