School of Medicine
Showing 1-10 of 140 Results
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Mauro Lago Docampo
Postdoctoral Scholar, Cardiology
Current Research and Scholarly InterestsI have always been fascinated by the process of genetic penetrance, how two people can carry the same mutation but only one of them may be affected.
My main project focuses on understanding the role of TBX4 in the development of Pulmonary Arterial Hypertension (PAH). Mutations in this gene are related to very different diseases. In my research, I mix cellular models, gene editing, and high throughput assays to find the determinants of penetrance in the development of PAH under these conditions. -
Mable Lam
Postdoctoral Scholar, Neurosurgery
Current Research and Scholarly InterestsMyelin is required for rapid nerve signaling by insulating axons to accelerate action potential propagation. Myelin-forming cells of the central nervous system, called oligodendrocytes, orchestrate one of the most complex morphological transformations in neurobiology. Each oligodendrocyte can extend multiple processes that selectively wrap axons in tens to hundreds of spiraling membrane layers, forming myelin sheaths that vary in thickness and length. Furthermore, oligodendrocytes can respond to neural activity by adding new sheaths or by changing the geometry of pre-existing sheaths to tune neural circuitry, a process known as adaptive myelination.
What are the membrane trafficking mechanisms that drive adaptive myelination in oligodendrocytes?
How can these mechanisms be stimulated to promote myelin regeneration in disease?
By using transgenic mouse models and primary oligodendrocytes, we have found that SNARE-mediated exocytosis drives membrane addition in myelin sheaths. Current research is focused on how these pathways in oligodendrocytes may be regulated during adaptive myelination. -
Tracy Lam-Hine
Postdoctoral Scholar, Epidemiology
BioTracy Lam-Hine (he/him), DrPH, MBA, is a postdoctoral scholar in the Department of Epidemiology and Population Health and the Center for Population Health Sciences, and a T32 trainee in the Division of Endocrinology, Gerontology, and Metabolism. Dr. Lam-Hine is a social and legal epidemiologist, studying how exposure to adverse childhood experiences and policy environments shape the risk of chronic disease and aging outcomes across the life course. Within this broad research area, he has a special focus on the health and social experiences of the US Multiracial population and the measurement of structural racism in policy. Dr. Lam-Hine also collaborates with state and local health jurisdictions in California and Hawaii in applied epidemiology and surveillance projects on topics including structural racism, adolescent health, and COVID-19.