School of Medicine
Showing 1-10 of 25 Results
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Mable Lam
Postdoctoral Scholar, Neurosurgery
Current Research and Scholarly InterestsMyelin is required for rapid nerve signaling by insulating axons to accelerate action potential propagation. Myelin-forming cells of the central nervous system, called oligodendrocytes, orchestrate one of the most complex morphological transformations in neurobiology. Each oligodendrocyte can extend multiple processes that selectively wrap axons in tens to hundreds of spiraling membrane layers, forming myelin sheaths that vary in thickness and length. Furthermore, oligodendrocytes can respond to neural activity by adding new sheaths or by changing the geometry of pre-existing sheaths to tune neural circuitry, a process known as adaptive myelination.
What are the membrane trafficking mechanisms that drive adaptive myelination in oligodendrocytes?
How can these mechanisms be stimulated to promote myelin regeneration in disease?
By using transgenic mouse models and primary oligodendrocytes, we have found that SNARE-mediated exocytosis drives membrane addition in myelin sheaths. Current research is focused on how these pathways in oligodendrocytes may be regulated during adaptive myelination. -
Maarten Lansberg, MD, PhD
Professor of Neurology (Adult Neurology) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsMy research involves the design and conduct of clinical trials to discover new treatments for patients who have suffered a stroke. These trials span treatment of acute stroke, stroke recovery, and stroke prevention. My research in acute stroke is primarily focused on the use of advanced neuroimaging methods (CT and MRI) to select patients who are most likely to benefit from therapies aimed at restoring blood flow to the brain in patients who have suffered a stroke.
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Jin Hyung Lee
Associate Professor of Neurology (Neurology Research Faculty), of Neurosurgery and of Bioengineering and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsIn vivo visualization and control of neural circuits
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Michael Leong
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Clinical Professor (By courtesy), NeurosurgeryCurrent Research and Scholarly Interests- Intrathecal / Intraspinal Analgesics
- Ziconotide (Prialt)
- Resiniferatoxin
- Industry-supported clinical trials -
Joshua Levin, MD
Clinical Associate Professor, Orthopaedic Surgery
Clinical Associate Professor, NeurosurgeryBioDr. Levin completed a residency in physical medicine and rehabilitation at the University of Michigan in 2007, and a pain medicine fellowship at the Virginia Commonwealth University in 2008. Currently, he is a member of both the departments of orthopedic surgery and neurosurgery at Stanford University, where he also is the director of the PM&R interventional spine fellowship and the director of the PM&R residency program.
