School of Medicine
Showing 1-10 of 27 Results
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Mable Lam
Instructor, Neurosurgery
Current Research and Scholarly InterestsMyelin is required for rapid nerve signaling by insulating axons to accelerate action potential propagation. Myelin-forming cells of the central nervous system, called oligodendrocytes, orchestrate one of the most complex morphological transformations in neurobiology. Each oligodendrocyte can extend multiple processes that selectively wrap axons in tens to hundreds of spiraling membrane layers, forming myelin sheaths that vary in thickness and length. Furthermore, oligodendrocytes can respond to neural activity by adding new sheaths or by changing the geometry of pre-existing sheaths to tune neural circuitry, a process known as adaptive myelination.
What are the membrane trafficking mechanisms that drive adaptive myelination in oligodendrocytes?
How can these mechanisms be stimulated to promote myelin regeneration in disease?
By using transgenic mouse models and primary oligodendrocytes, we have found that SNARE-mediated exocytosis drives membrane addition in myelin sheaths. Current research is focused on how these pathways in oligodendrocytes may be regulated during adaptive myelination. -
Maarten Lansberg, MD, PhD
Professor of Neurology and Neurological Sciences (Adult Neurology) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsMy research involves the design and conduct of clinical trials to discover new treatments for patients who have suffered a stroke. These trials span treatment of acute stroke, stroke recovery, and stroke prevention. My research in acute stroke is primarily focused on the use of advanced neuroimaging methods (CT and MRI) to select patients who are most likely to benefit from therapies aimed at restoring blood flow to the brain in patients who have suffered a stroke.
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Jin Hyung Lee
Associate Professor of Neurology and Neurological Sciences (Neurology Research), of Neurosurgery and of Bioengineering and, by courtesy, of Electrical Engineering
On Leave from 09/22/2025 To 12/12/2025Current Research and Scholarly InterestsIn vivo visualization and control of neural circuits
