School of Medicine
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Jessica B. Sarthi
Basic Life Research Scientist, Pediatrics - Gastroenterology
BioMolecular and Cellular Biologist (Ph.D.) with over 10 years of scientific research experience. Accomplished in developing, optimizing, validating and implementing new ideas and technology. Experience in managing and coordinating collaborative teams comprised of scientists and research technicians working to advance scientific knowledge. Technical experience in precision medicine diagnostics, cancer biology, neurobiology and epigenetics as well as in various molecular, biochemical and cell biology techniques.
Zachary M. Sellers, MD, PhD
Assistant Professor of Pediatrics (Gastroenterology)
BioI am a pediatric physician-scientist striving to advance cystic fibrosis clinical care and translational research. Clinically, I am focused on gastrointestinal manifestations of cystic fibrosis, developing diagnostic and therapeutic modalities to improve the gastrointestinal and liver health of those with cystic fibrosis. I also specialize in the clinical management of pediatric pancreatitis and am involved with the international INSPPIRE consortium to study pediatric pancreatitis. My research spans the entire spectrum across basic science and translational research to clinical research and trials. In the laboratory, my projects are centered around understanding mechanisms of ion transport in cystic fibrosis tissues and determining how loss of CFTR ion transport leads to pathologic changes in human physiology. We are also very interested in the pathophysiological relationship between pancreatitis and intestinal diseases, such as inflammatory bowel disease. Our laboratory has expertise in epithelial ion transport, with specialized skills in the measurement of bicarbonate transport. We are also part of a Multi-PI collaboration pursuing CFTR gene editing and stem cell engraftment for the treatment of cystic fibrosis. We utilize a combination of immortalized and primary cell culture, organoids, mouse and human tissue, and whole animal in vivo studies.
Eric Sibley, M.D., Ph.D.
Professor of Pediatrics (Gastroenterology)
Current Research and Scholarly InterestsMolecular Regulation of Intestinal Development and Maturation. We study transcriptional mechanisms regulating the spatial and temporal restriction of intestine-specific gene expression during gut development. Our approach is to characterize the function of gene-specific DNA cis elements and interacting nuclear proteins in cell culture and in transgenic animals. The goal is to relate the gene-specific control mechanisms to the broader pathways specifying acquisition of gut phenotypes.