School of Medicine
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Lindhard Family Professor of Pediatric Cancer Biology
BioOur laboratory focuses on investigating molecular mechanisms of oncogene-induced tumorigenesis and tumor suppressor pathways, and oncogenic signaling in the pediatric solid tumor rhabdomyosarcoma. Our earlier work identified the tumor suppressors p53 and p18Ink4c as inhibitors of Cyclin D1-driven tumorigenesis in a pineoblastoma model, through senescence induction, and highlighted distinct roles for the the RB and p53 pathways in induction and maintenance of oncogene-induced senescence. We also identified CDK2 as a potential target for inducing senescence in premalignant lesions to inhibit tumor progression.
Our current focus is on studying oncogenic signaling and tumor suppression in the childhood tumor rhabdomyosarcoma, to identify key mediators of invasion and metastasis, which is the most common cause of treatment failure clinically. We use preclinical in vitro and in vivo models, including murine and human cell lines, and mouse models of disease.
We have recently uncovered a paracrine role for rhabdomyosarcoma-secreted exosomes in impacting biology of stromal cells. Rhabdomyosarcoma-derived exosomes carry specific miRNA cargo that imparts an invasive and migratory phenotype on normal recipient fibroblasts, and proteomic analysis revealed specific and unique pathways relevant to the two different molecular rhabdomyosarcoma subtypes that are driven by distinct oncogenic pathways. We identified that the driver oncogene in fusion-positive rhabdomyosarcoma, PAX3-FOXO1, modulates exosome cargo to promote invasion, migration, and angiogenic properties, and identified specific microRNA and protein cargo acting as effectors of PAX3-FOXO1 exosome-mediated signaling, including modulation of oxidative stress response and cell survival signaling.
Our ongoing work is focused on interrogating specific paracrine signaling pathways and molecular mechanisms of metastatic disease progression in rhabdomyosarcoma, for potential therapeutic targeting.
Clinical Assistant Professor, Pediatrics - Immunology and Allergy
Current Research and Scholarly InterestsAllergy, Immunology, Bioengineering and Biodesign
Elaine and John Chambers Professor of Pediatric Cancer and Professor of Genetics
Current Research and Scholarly InterestsWe investigate the mechanisms by which normal cells become tumor cells, and we combine genetics, genomics, and proteomics approaches to investigate the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells and to identify novel therapeutic targets in cancer cells.
Debbie C. Sakaguchi Sakai
Clinical Professor, Pediatrics
Current Research and Scholarly InterestsMedical education, shared decision making, resuscitation.
Kathleen M. Sakamoto
Shelagh Galligan Professor in the School of Medicine
Current Research and Scholarly InterestsMy research focuses on the molecular pathways that regulate normal and aberrant blood cell development, including acute leukemia and bone marrow failure syndromes. We are also studying novel drugs for treatment of cancer.
Professor of Pediatrics (Rheumatology), Emerita
Current Research and Scholarly InterestsThe major emphasis of my work in the past 2 decades has been focused on the future of academic pediatrics and pediatric rheumatology through providing training, research opportunities and environments to nurture and challenge future pediatric rheumatologists and subspecialists. In parallel in the last decade, my scope has included to workforce and physician wellbring, patient and family centered care--and more recently, diversity, equity and inclusion, and health equity.
Kelly Corbett Sanders
Clinical Instructor, Pediatrics - General Pediatrics
BioDr. Kelly Sanders is a Stanford pediatrician and the Technical Lead of the Pandemic Response Initiative at the University of California San Francisco (UCSF) Institute for Global Health Sciences. She completed a Master of Science and Doctor of Medicine at the University of San Francisco, California, and pediatrics residency training at Lucile Packard Children’s Hospital at Stanford University. Before pursuing a career as a physician, Dr. Sanders worked with the UCSF Global Health Group’s Malaria Elimination Initiative (MEI) on operational research projects with partner countries, as well as on developing communications and advocacy priorities with MEI and global partners. Previously, she worked with the UCSF Institute for Global Health Sciences, supporting the creation of the Consortium of Universities for Global Health and the UC Global Health Institute. In addition to her work at UCSF, Dr. Sanders practices clinically as a pediatrician at Stanford University, Palo Alto Medical Foundation and Santa Clara Valley Medical Center.