School of Medicine
Showing 1,061-1,080 of 1,307 Results
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Marcia L. Stefanick, Ph.D.
Professor (Research) of Medicine (Stanford Prevention Research Center), of Obstetrics and Gynecology and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsMarcia L. Stefanick, Ph.D is a Professor of Medicine Professor of Obstetrics and Gynecology, and by courtesy, Professor of Epidemiology and Population Health at Stanford University School of Medicine. Dr. Stefanick’s research focuses on chronic disease prevention (particularly, heart disease, breast cancer, osteoporosis, and dementia) in both women and men. She is currently the Principal Investigator the Women’s Health Initiative (WHI) Extension Study, having been the PI of the Stanford Clinical Center of the landmark WHI Clinical Trials and Observational Study since 1994 and Chair of the WHI Steering and Executive Committees from 1998-2011, as well as PI of the WHI Strong and Healthy (WHISH) Trial which is testing the hypothesis that a DHHS-based physical activity intervention, being delivered to a multi-ethnic cohort of about 24,000 WHI participants across the U.S., aged 68-99 when the trial started in 2015, will reduce major cardiovascular events over 8 years, compared to an equal number of “usual activity” controls. Dr. Stefanick is also PI of the Osteoporotic Study of Men (MrOS) which is continuing to conduct clinical assessments of bone and body composition in survivors of an original cohort of nearly 6000 men aged 65 and over in 2001. As founding Director of the Stanford Women’s Health and Sex Differences in Medicine (WHSDM, “wisdom”) Center, she plays a major role in promoting research and teaching on Sex and Gender in Human Physiology and Disease, Women’s Health and Queer Health and Medicine. Dr. Stefanick also plays major leadership roles at the Stanford School of Medicine, including as co-leader of the Population Sciences Program of the Stanford Cancer Institute, Stanford’s NCI-funded comprehensive cancer center.
Dr. Stefanick obtained her B.A. in biology from the University of Pennsylvania, Philadelphia, PA (1974), then pursued her interest in hormone and sex difference research at the Oregon Regional Primate Research Center, after which she obtained her PhD in Physiology at Stanford University, focusing on reproductive physiology and neuroendocrinology, with exercise physiology as a secondary focus. Her commitment to human research led to a post-doctoral fellowship in Cardiovascular Disease Prevention at the Stanford Prevention Research Center, which has been her academic home for nearly 40 years. -
Katherine Steffen
Clinical Associate Professor, Pediatrics - Critical Care
Current Research and Scholarly InterestsMy research interests focus on using dissemination and implementation science tools to study and enhance care provided to patients in the pediatric ICU. I have a background in human factors research and in implementation science and am also interested in clinical effectiveness and outcomes in the PICU.
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Lea Steffes
Instructor, Pediatrics - Pulmonary Medicine
BioDr. Steffes, a Wisconsin native, completed medical school and pediatric residency at the Medical College of Wisconsin. She then moved to the Bay Area and completed her clinical fellowship in pediatric pulmonary medicine at Stanford University in 2020. Additionally, Dr. Steffes received further post-doctoral training in the laboratories of Dr. Maya Kumar and Dr. David Cornfield, studying the cellular and molecular mechanism driving pulmonary vascular disease. In addition to her role as an Instructor in Pediatrics in the division of Pulmonary Medicine, Dr. Steffes is also completing an advanced clinical fellowship in Pulmonary Hypertension at Lucile Packard Children’s Hospital Stanford. Her clinical work consists of caring for patients with pediatric pulmonary and pulmonary vascular diseases such as pulmonary hypertension, bronchopulmonary dysplasia, interstitial lung disease, respiratory failure, chronic cough and asthma. Her research is focused on the vascular changes seen in pulmonary hypertension, more specifically understanding the cellular characteristics of occlusive neointimal lesions, the abnormal cells that block pulmonary blood flow in pulmonary hypertension. In her most recent work, Dr. Steffes identified a subset of healthy vascular smooth muscle cells that are the cell of origin for the pathologic neointimal cells and a specific signaling pathway, that when blocked, inhibits the formation of neointimal lesions.
Dr. Steffes is currently employing advanced single cell sequencing technologies to further understand neointimal cells with the ultimate goal identifying new therapies for pulmonary hypertension, a fatal disease with no known cure. -
Robert Steffner
Clinical Associate Professor, Orthopaedic Surgery
BioDr. Steffner specializes in the evaluation, diagnosis, and treatment of bone and soft tissue tumors in pediatric and adult patients. This includes primary bone and soft tissue sarcomas, locally active conditions such as giant cell tumor, aneurysmal bone cyst, and chondroblastoma, as well as impending and pathologic fractures from metastatic carcinoma, multiple myeloma, and lymphoma. He works closely with the multidisciplinary sarcoma group at the Stanford Cancer Center to provide coordinated, highly specialized treatment strategies.
Research interests include circulating tumor DNA in bone and soft tissue sarcomas, local drug delivery, establishment of a national bone and soft tissue registry, and collaborative clinical studies on imaging and soft tissue management. -
Henning Stehr
Clinical Assistant Professor, Pathology
Current Research and Scholarly InterestsBioinformatics & Clinical Cancer Genomics
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Harise Stein
Adjunct Clinical Professor, Obstetrics & Gynecology - General
BioDr. Harise Stein has had multiple clinical, teaching and administrative roles at Stanford in addition to her private practice. In June 2022 she semi-retired, closing her private office and stopped seeing patients in Stanford ob/gyn clinics.
-- Stanford Physician PRN Support Program, where having served as an initial member of the physician wellness committee, a peer support trainer, author of the peer support manual and program Director for several years, she has now stepped down to a peer supporter. In addition, for 8 years, up until January 2019, she served as the WellMD Newsletter editor, and was the creator and webmaster for the WellMD website. She has been a frequent speaker on topics of burnout and resilience for medical and community groups.
-- Founder and Co-Chair of Stanford Family Abuse Prevention Council, teaching medical and community members about the health effects, recognition and management of partner and family abuse. She has created Stanford websites for domestic abuse, child abuse, elder abuse and human trafficking, as well as a monthly abuse research summary (see next section). In addition, she served for seven years as a Commissioner on the Santa Clara County Domestic Violence Council and has been a member of the LPCH Suspected Child Abuse and Neglect Committee.
-- Editor of monthly Abuse Research newsletter (abuseresearch.info), summarizing the most important articles indexed by the NLM each month on the health effects of abuse. This newsletter goes out to a large local, national and international audience of clinicians, researchers, advocates, judiciary/law, government officials and policy makers.
-- Stanford Integrative Medicine Society, as a founding member and webmaster, and until recently serving as the Director of Stanford Ob/Gyn Preoperative Mind-Body Support program, preparing patients in ob and gyn clinics for upcoming surgery using various techniques including education, mindfulness, relaxation and positive psychology.
Through her many years of caring for patients and fellow physicians, she has come to believe that the most important root factor in health and well-being is the power of relationships - how family members treat each other, the impact of an optimal patient-physician interaction, the support of medical colleagues by and for each other, and their relationship with their institution. -
Gary K. Steinberg, MD, PhD
Bernard and Ronni Lacroute-William Randolph Hearst Professor of Neurosurgery and Neurosciences and Professor, by courtesy, of Neurology
Current Research and Scholarly InterestsOur laboratory investigates the pathophysiology and treatment of cerebral ischemia, and methods to restore neurologic function after stroke. Treatment strategies include brain hypothermia, stem cell transplantation and optogenetic stimulation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease, as well as stem cell transplant.
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David Steiner
Adjunct Clinical Assistant Professor, Pathology
Current Research and Scholarly InterestsMechanistic and translational studies to better understand the functional and clinical implications of somatic mutations in aging and cancer.
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Lawrence Steinman, MD
George A. Zimmermann Professor and Professor of Pediatrics
Current Research and Scholarly InterestsOur laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.
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Lars Steinmetz
Dieter Schwarz Foundation Endowed Professor
Current Research and Scholarly InterestsWe apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.
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Laurel Stell
Research Engineer, Biomedical Data Science
Current Role at StanfordInvestigating non-glycemic genetic effects on HbA1c using the Veterans Administration Million Veteran Program (MVP). HbA1c is a widely used test that reflects average blood sugar level for the past two to three months. It is well known that certain genetic blood conditions, such as sickle cell disease, can cause HbA1c to be a misleading indicator of blood glucose levels. I am investigating the extent to which genetic variants can have this effect even without a diagnosis of one of these conditions. I am also investigating whether these effects are impacting clinical diagnosis and treatment of diabetes, and whether such impacts are reflected in health outcomes.
The impact of these variants has potentially been overlooked because they are very rare in populations with European genetic ancestry. As with the variant for sickle cell disease, they only persist when they provide an evolutionary advantage, such as protecting against malaria infection and its symptoms. Consequently, the genetic variants that I am analyzing do not appear in most genetic biobanks frequently enough to enable my analyses. MVP, however, includes genetic data for over 100,000 Veterans with African genetic ancestry, making it an ideal resource for this research. Since these variants are common among individuals with African genetic ancestry but practically non-existent in European genetic ancestry, this research may provide insight into racial health disparities in the US, particularly in T2D prevalence and outcomes.
I've also been a member of the department's JEDI Committee since its inception in 2021, providing assistance wherever I can.
