School of Medicine
Showing 571-580 of 1,220 Results
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Calvin Kuo
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
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Christin S Kuo
Assistant Professor of Pediatrics (Pulmonary Medicine)
BioDr. Kuo is a physician-scientist with expertise in single-cell genomics and pulmonary medicine. She has made pioneering contributions to pulmonary neuroendocrine cell (PNEC) biology by developing innovative strategies that established the first comprehensive framework for understanding the molecular and cellular diversity of normal PNECs and their roles in health and disease. Her discoveries have laid the foundation for this emerging field and her contributions are recognized internationally.
PNECs are exceedingly rare lung epithelial cells with specialized airway sensory, secretory, and stem cell functions. These neurosensory cells are thought to monitor airway oxygen, chemicals, mechanical deformation, infection, and injury, and serve as sentinels that signal this sensory information locally in the lung, to the brain through synapses with pulmonary sensory neurons and potentially globally throughout the body via secretion of myriad local signals and hormones. PNECs are also known to play critical roles in the control of breathing, cough, and respiratory physiology. Among their diverse physiologic functions, their response to injury has been most intensively studied in murine models and they are a cell of origin for high grade lung neuroendocrine tumors.
Dr. Kuo performed the first comprehensive anatomical mapping and lineage tracing studies of PNECs in mice which generated a foundational understanding of PNEC development (Kuo and Krasnow, Cell 2015). She also led single cell transcriptomic profiling studies that revealed a surprising diversity in PNEC sensors and signals (Kuo et al, eLife 2022). PNECs express over 25 different sensory receptor genes ("sensors") and over 40 different neuropeptide and peptide hormone genes ("signals"). Her scRNA-seq analysis of PNECs revealed a remarkable number and diversity of PNEC neuropeptide signals and their predicted cellular targets both within the lung and to innervating sensory neurons (Kuo et al., 2022, eLife).
In contrast to the advanced understanding of PNEC development, stem cell, and signaling function in mouse, little is known about human PNECs. To compare the findings of PNEC development, diversity, and function in mouse models to human diseases, her lab recently established a platform to systematically construct a human PNEC atlas. This foundational work created a molecular and anatomic framework for the entire human pulmonary neuroendocrine system and the diseases that are predicted to originate from distinct PNECs. Her lab has recently used this new PNEC atlas combined with single cell transcriptomic approaches to identify the molecular diversity of anatomically and functionally distinct human PNECs.
Dr. Kuo's studies with human models extends her lab’s current research aims to define the diverse neuroendocrine sensory and signaling interactions and the molecules that mediate them to their roles in lung cancer, neuroendocrine proliferative disorders such as diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH), neuroendocrine cell hyperplasia of infancy (NEHI) and major inflammatory and obstructive pulmonary diseases. Dr. Kuo’s lab engages a network of collaborators to develop and implement clinical protocols and strategically apply cutting-edge technologies to studying minor, but physiologically diverse airway sentinels.
Please visit the research website for additional information and current research areas (https://kuo.stanford.edu). -
Clete A. Kushida, MD, PhD
Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsDr. Kushida is a neurologist and sleep specialist who directs several NIH- and industry-sponsored research studies, focused on topics such as the physical features and neurocognitive changes associated with the obstructive sleep apnea syndrome, the epidemiology and treatment of restless legs syndrome/periodic limb movement disorder, primary care sleep education and training, and countermeasures for sleep loss.
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Angelle Desiree LaBeaud
Professor of Pediatrics (Infectious Diseases), Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Epidemiology and Population Health and of Environmental Social Sciences
Current Research and Scholarly InterestsArthropod-borne viruses are emerging and re-emerging infections that are spreading throughout the world. Our laboratory investigates the epidemiology of arboviral infections, focusing on the burden of disease and the long-term complications on human health. In particular, Dr. LaBeaud investigates dengue, chikungunya, and Rift Valley fever viruses in Kenya, where outbreaks cause fever, arthritis, retinitis, encephalitis, and hemorrhagic fever. Our main research questions focus on the risk factors for arboviral infections, the development of diagnostic tests that can be administered in the field to quickly determine what kind of arboviral infection a person has, and the genetic and immunologic investigation of why different people respond differently to the same infection. Our long-term goals are to contribute to a deeper understanding of arboviral infections and their long-term health consequences and to optimize control strategies to prevent these emerging infections. Our laboratory also investigates the effects of antenatal and postnatal parasitic infections on vaccine responses, growth, and development of Kenyan children.
My lab at Stanford supports the field work that is ongoing in Kenya, but we also have several projects that are based locally. We strive to improve diagnostics of arboviral infections and are using Luminex technology to build a new screening assay. We also have created a Luminex based platform to assess vaccine responses against multiple pathogens. -
Norman J. Lacayo, MD
Associate Professor of Pediatrics (Hematology and Oncology)
Current Research and Scholarly InterestsPediatric Hematology/Oncology, Phase I drug studies for refractory and relapsed leukemia; genomic studies, biologic risk-stratification and treatment of acute myeloid leukemia; prediction or induction response and risk of relapse using phosphoproteomics in childhood AML; novel MRD techniques in childhood ALL.
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Amy Ladd, MD
Elsbach-Richards Professor of Surgery, Emerita
Current Research and Scholarly InterestsResearch Interests
1. The kinematics and forces associated with thumb carpometcarpal (CMC) function and pathology
2. The anatomy, microstructure, and immunofluorescent characteristics of the thumb CMC joint
3. Pathomechaniics of CMC arthritis: biomechanical wear, injury, genetic, and environmental causes
4. Biomechanics of the golf swing
5. Archiving, vitalizing, and innovating medical and surgical knowledge, most recently with innovative iBook monographs -
Teresa LaFromboise
Professor of Education
Current Research and Scholarly InterestsBicultural competence and resilience in ethnic minority adolescent development. Particularly, the influence of enculturation and acculturation experiences on adolescent development. Cultural considerations in individual, school and community-based psychological interventions with adolescents and emerging adults.
