School of Medicine
Showing 1-10 of 21 Results
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Carol Clayberger
Professor (Research) of Pediatrics, Emerita
Current Research and Scholarly InterestsOur group uses molecular biology, biochemistry, and cellular immunology to investigate the activation and effector function of T lymphocytes. Research in the laboratory is currently focused on three areas: granulysin, a lytic molecule expressed late (7-12 days) after T cell activation; identification of correlates of immunity in diseases such as tuberculosis; and tolerance. The long term goal of this work is to develop new ways to treat human disease.
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Yael Gernez
Clinical Associate Professor, Pediatrics - Immunology and Allergy
BioMy clinic focuses on solving the molecular puzzles that underlie rare allergic and immunologic diseases to shed light on fundamental principles governing allergy, inflammation and immune system defects. My goal is to find better and safer therapies for my patients with rare diseases that include autoinflammation, autoimmunity and primary immune deficiency. It is important to highlight that every patient requires individualized therapeutic approaches based on their underlying genetic problem and the types and severity of their clinical manifestations. For some patients, a hematopoietic stem cell transplant (HSCT) is curative while for others, a targeted drug therapy, such as a biologic or small molecule agent, is most suitable. In some cases, a truly novel therapy may be required, .e.g., anti-sense oligonucleotide therapy to suppress aberrant gene splicing or adoptive cellular therapy. My passion is to provide the best personalized therapy for our patients with allergy and immunology diseases. This often requires performing very specialized functional assays and in some cases in enlisting laboratories with specific expertise or interest in particular genetic disorders.
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Joseph Hernandez
Clinical Assistant Professor, Pediatrics - Immunology and Allergy
BioI have a research background in basic immunology/biochemistry and animal/cellular models of allergic disease. Since 2016, I have been a full time clinical faculty member caring for patients with a variety of allergic diseases and immune deficiency. I have been involved as a participating clinician and investigator with the PANS clinic at LPCH.
