School of Medicine
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Christopher O. Barnes
Assistant Professor of Biology and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsResearch in our lab is aimed at defining the structural correlates of broad and potent antibody-mediated neutralization of viruses. We combine biophysical and structural methods (e.g., cryo-EM), protein engineering, and in vivo approaches to understand how enveloped viruses infect host cells and elicit antigen-specific immune responses. We are particularly interested in the co-evolution of HIV-1 and broadly-neutralizing IgG antibodies (bNAbs), which may hold the key to the development of an effective HIV-1 vaccine. In addition, we are investigating antibody responses to SARS-CoV-2 and related zoonotic coronaviruses (CoV), with the related goal of developing broadly-protective immunotherapies and vaccines against variants of concern and emerging CoV threats.
HIV-1; SARS-CoV-2; coronaviruses; cryo-EM; crystallography; vaccines; directed evolution -
Andrew Beel
Instructor, Structural Biology
BioAndrew Beel received an M.D. and a Ph.D. in Biophysics from Stanford, where he studied the structure and condensation of the eukaryotic chromosome under the supervision of Roger Kornberg. He started his independent research program in late 2022 after receiving an Early Independence Award from the Office of the Director of the National Institutes of Health. His group is broadly interested in mesoscale biological organization and the physical underpinnings thereof, with a current emphasis on the axial core of the metaphase chromosome. The Beel lab is actively recruiting new members at all stages of training; interested parties are encouraged to apply (please direct inquiries to beelaj@stanford.edu).
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Axel Brunger
Professor of Molecular and Cellular Physiology, of Neurology and Neurological Sciences, of Photon Science and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsOne of Axel Brunger's major goals is to decipher the molecular mechanisms of synaptic neurotransmitter release by conducting imaging and single-molecule/particle reconstitution experiments, combined with near-atomic resolution structural studies of the synaptic vesicle fusion machinery.
