School of Medicine
Showing 1-50 of 117 Results
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Ronaldo Francisco Jr
Postdoctoral Scholar, Pathology
BioI am a geneticist focused on the application of computational and statistical methods to study genetic mechanisms of disease. My research interests include (i) genomic and precision medicine; (ii) detection and analysis of genetic variants using NGS data (WGS, WES, RNA-Seq); and (iii) transcriptome and allele-specific expression.
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Dr. Qiwen Deng
Postdoctoral Scholar, Pathology
BioHow fibroblasts participate in the organ fibrosis and whether targeting fibroblasts is a good strategy to reverse fibrosis is still a mystery. We have identified two important immune checkpoints, CD47 and PD-L1, are highly expressed in fibroblasts and blocking CD47 and PD-L1 reversed lung fibrosis. This is a prove of concept that targeting immune regulatory pathways could be an effective therapeutic approach to treat fibrotic diseases. In addition to identifying novel targets for the treatment of fibrosis, I am also interested in the crosstalk between fibroblasts and innate immune cells in the development of fibrosis. Combined with cutting-edge NGS approaches including single cell sequencing, spatial transcriptomics and high-dimensional CyTOF technique, we have identified several potential targets and characterized immune cells landscape in lung fibrosis. In the long run, I will focus on the validation of these targets. Specifically, I will apply gain- and loss-function approaches to investigate their role in fibrosis in vitro and in vivo.
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Jelle Folkerts
Postdoctoral Scholar, Pathology
BioDr. Folkerts received his master's degree in Drug Innovation from Utrecht University in the Netherlands, during which he spent a year at the Galli lab at Stanford on a Fulbright Scholarship. During this time, Dr. Folkerts played a key role in developing a technology platform employing functional genomics and high-resolution single-cell confocal imaging, enabling the rapid identification of degranulation regulators in primary human mast cells. Following his time at Stanford, Dr. Folkerts studied the regulatory mechanisms of human mast cell activation under the guidance of Rudi Hendriks and Marcus Maurer, earning his Ph.D. in 2022. He then returned to Stanford as a postdoctoral fellow in the Galli lab, where his current research focuses on the identification of human mast cell degranulation regulators using a whole-genome CRISPR knockout library screen, and the validation of these findings using the recently developed technology platform. It is his long-standing goal to contribute to the design and development of specific and effective therapeutic interventions for mast cell-mediated diseases.
