School of Medicine
Showing 3,251-3,300 of 4,961 Results
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Angelika Pahulu
HR Coordinator, Educational Programs and Services
Current Role at StanfordTraining Coordinator
Handle all Cardinal Curriculum related issues
Plan ABC Research Meetings
Maintain and approve content on the DoResearch website -
Jennifer Yi-Jiun Pan
Clinical Assistant Professor (Affiliated), Medicine - Med/Gastroenterology and Hepatology
Staff, Medicine - Med/Gastroenterology and HepatologyBioMy research interests thus far have focused on immunology, GI cancers, and improving quality of care for patients. I am passionate about understanding the different genetic and lifestyle factors that are involved in GI cancers and other colonic pathology, as well as improving systems of care to better manage the health and improve the outcomes of patients with these diseases. Towards that end, I have been involved in research in Lynch syndrome in order to bridge the gap between our current understanding of cancer risk in this high-risk population and the creation and implementation of guidelines worldwide. I also had the opportunity to work with collaborators in the International Mismatch Repair Consortium at the Department of Colorectal Medicine and Genetics with the Royal Melbourne Hospital in Australia where I saw firsthand the global efforts in the fight against colorectal cancer. In my current role as a staff gastroenterologist at the VA Palo Alto, I oversee the colorectal cancer prevention program. My goal is to continue to be part of and contribute to collaborative clinical and research efforts in order to provide the best care for our patients.
Selected NCBI Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/jennifer.pan.1/bibliography/public/ -
Vijay Pande
Adjunct Professor, Structural Biology
BioVijay Pande, Henry Dreyfus Professor of Chemistry and, by courtesy, of Structural Biology and Computer Science, also currently directs of the Stanford Program in Biophysics and the Folding@home Distribtued Computing project. His research centers on novel cloud computing simulation techniques to address problems in chemical biology. In particular, he has pioneered distributed computing methodology to break fundamental barriers in the simulation of protein and nucleic acid kinetics and thermodynamics. As director of the Folding@home project (http://folding.stanford.edu), Prof. Pande has, for the first time, directly simulated protein folding dynamics, making quantitative comparisons with experimental results, often considered a “holy grail” of computational biology. His current research also includes novel computational methods for drug design, especially in the area of protein misfolding and associated diseases such as Alzheimer’s and Huntington’s Disease.
Professor Pande studied physics at Princeton University (B.A. 1992), where he was first introduced to biophysical questions, especially in undergraduate research with Nobel Laureate P. Anderson. His doctoral research in physics under Profs. T. Tanaka and A. Grosberg at MIT (Ph.D. 1995) centered on statistical mechanical models of protein folding, suggesting new ways to design protein sequences for stability and folding properties. As a Miller Fellow under Prof. D. Rokhsar at UC Berkeley, Prof. Pande extended this methodology to examine atomistic protein models, laying the foundations for his work at Stanford University. Among numerous awards, Prof. Pande has received the Biophysical Society’s Bárány Award for Young Investigators and Protein Society’s Irving Sigal Young Investigator Award, and was named to MIT’s TR100 and elected a Fellow of the American Physical Society.
The Pande research group develops and applies new theoretical methods to understand the physical properties of biological molecules such as proteins, nucleic acids and lipid membranes, using this understanding to design synthetic systems including small-molecule therapeutics. In particular, the group examines the self-assembly properties of biomolecules. For example, how do protein and RNA molecules fold? How do proteins misfold and aggregate? How can we use this understanding to tackle misfolding related degeneration and develop small molecules to inhibit disease processes?
As these phenomena are complex, spanning molecular to mesoscopic lengths and nanosecond to millisecond timescales, the lab employs a variety of methods, including statistical mechanical analytic models, Markov State Models, and statistical and informatic methods. Other tools include Monte Carlo, Langevin dynamics, and molecular dynamics computer simulations on workstations and massively parallel supercomputers, superclusters, and worldwide distributed computing. The group has also done extensive work in the application of machine learning, pioneering traditional and deep learning approaches to cheminformatics, biophysics and drug design.
For example, simulations in all-atom detail on experimentally relevant timescales (milliseconds to seconds) have produced specific predictions of the structural and physical chemical nature of protein aggregation involved in Alzheimer’s and Huntington’s diseases. These results have fed into computational small molecule drug design methods, yielding interesting new chemical entities.
Since such problems are extremely computationally demanding, the group developed a distributed computing project for protein folding dynamics. Since its launch in October 2000, Folding@Home has attracted more than 4,000,000 PCs, and today is recognized as the most powerful supercluster in the world. Such enormous computational resources have allowed simulations of unprecedented folding timescales and statistical precision and accuracy. For more details, please visit http://pande.stanford.edu. -
Heather Ryan Pankow
Life Science Rsch Prof 2, Psych/General Psychiatry and Psychology (Adult)
Current Role at StanfordLife Science Research Professional 2 in The Depression Research Clinic
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Sofia Pantis
Research Assistant, Neurology
Current Role at StanfordResearch Assistant - Laboratory of Behavioral and Cognitive Neuroscience (Parvizi Lab) - Stanford School of Medicine, Department of Neurology and Neurological Sciences
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Lori D Panu
Sr. Program Manager, Clinical Research Operations, Med/Stanford Center for Clinical Research
Current Role at StanfordSr. Program Manager, Clinical Research Operations
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Vedant Pargaonkar
Basic Life Research Scientist, Medicine - Med/Cardiovascular Medicine
BioMy long-term research interests involve development of algorithms using computational methods for early detection of coronary pathophysiology including, endothelial dysfunction and microvascular dysfunction (MVD) and/or a myocardial bridge (MB) in patients with angina and no obstructive coronary artery disease (NOCAD) and the identification of novel target therapies for primary prevention and improved prognosis in these patients. Under the mentorship of Dr. Jennifer Tremmel in Cardiovascular medicine at Stanford, I have been systematically studying to better understand the underlying pathophysiology of these patients, as well as the optimal use of diagnostic testing and treatment using the angina and no-obstructive CAD Registry at Stanford. In collaboration with other investigators in this field, we have published multiple scientific articles highlighting the limitations of current testing in this population and identification of novel diagnostic tools for early diagnosis and management of patients with angina and no obstructive CAD. My research also focuses on myocardial infarction (MI) in women, particularly spontaneous coronary artery dissection (SCAD). I have been involved in the design and execution of the first international collaborative study in SCAD, investigating peripartum vs. non-peripartum SCAD. This is analyzing the largest cohort of patients recruited from multiple US and non-US sites to understand the pathophysiological differences in these patient cohorts.
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Mitchel Pariani
Clinical Assistant Professor (Affiliated), Pediatrics - Genetics
BioMitchel earned his Master’s degree in genetic counseling from California State University, Northridge in 2007. At Cedars-Sinai Medical Center Mitchel served as genetic counselor and coordinator for David Rimoin, MD, PhD’s connective tissue disorders clinic and later established the cardiovascular genetics program at CSMC. At CSMC he also created the CSMC Summer Genetic Counseling Rotation Program that hosted students from genetic counseling programs around the United States. In 2014 he joined the new Stanford Center for Inherited Cardiovascular Disease to start a familial hypercholesterolemia clinic and provide genetic counseling for patients with cardiomyopathies. As the center expanded, Mitchel joined the Stanford Marfan Center as a genetic counselor and serves as program coordinator. He is the primary instructor for Stanford’s Cardiovascular Genetics course and serves as a clinical supervisor and mentor for students and volunteers.
