Stanford University
Showing 491-500 of 560 Results
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David N. Cornfield
Anne T. and Robert M. Bass Professor of Pediatric Pulmonary Medicine
Current Research and Scholarly InterestsOver the past 20 years, the Cornfield Laboratory has focused upon basic, translational and clinical research, with a primary focus on lung biology. As an active clinician-scientist, delivering care to acutely and chronically ill infants and children, our lab focuses on significant clinical challenges and tried to use science to craft novel solutions to difficult clinical problems.
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Steven M. Corsello
Assistant Professor of Medicine (Oncology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur laboratory operates at the intersection of functional genomics and chemical biology, with the goal of advancing novel molecular mechanisms of cancer inhibition to clinical use. We aim to 1) leverage phenotypic screening and functional genomics to determine novel anti-cancer mechanisms of small molecules, 2) develop new targeted therapy approaches against solid tumors, and 3) build a comprehensive community resource for drug repurposing discovery.
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Ximena Corso Díaz
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsWe are interested in unraveling the roles of RNA-binding proteins (RBPs) and regulatory RNAs in retinal development and homeostasis.
RNA-binding proteins mediate functional integration of transcriptional and post-transcriptional machineries influencing various aspects of gene expression and RNA metabolism. Several RBPs have cell-type enriched expression patterns in the retina or cause blinding diseases, however their role in retinal development and function is poorly understood. We have identified several RBPs that interact with the photoreceptor-specific transcription factor NRL and are likely involved in development and homeostasis of this retinal cell-type. We are pursuing the following lines of research:
1) RBPs in retinal development and degeneration. We will study the role of RBPs in regulating retinal development and maintaining homeostasis. We will focus on RBPs enriched in the retina, their interactions with retinal transcription factors like NRL, and their relevance to retinal diseases.
2) RBPs in R-loop regulation in the retina. R-loops are triple-stranded structures created when RNA anneals to one of the strands of the DNA duplex. R-loops have many regulatory roles during gene expression and their dysregulation can be detrimental to genome integrity. We observed that R-loops are dynamic during retinal development and identified key R-loop-associated RBPs that are enriched in rod photoreceptors and that interact with the transcription factor NRL. We will study the role of R-loops and their regulatory RBPs in retinal development and homeostasis.
3) Chromatin-associated regulatory RNAs through the retina lifespan. Chromatin-associated RNAs contribute to the dynamic regulation of gene expression, chromatin structure, and genome organization, playing essential roles in various biological processes, including development, differentiation, and disease. We will study how regulatory RNAs, together with their cognate RBPs, influence expression programs and chromatin dynamics through the retina lifespan. -
Victoria Cosgrove
Assistant Professor of Psychiatry and Behavioral Sciences (Child and Adolescent Psychiatry and Child Development)
Current Research and Scholarly InterestsDr. Cosgrove studies putative roles for life and family stress as well as inflammatory and neurotrophic pathways in the etiology and development of mood disorders across the life span.
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Ioanida Costache
Assistant Professor of Music
BioIoanida Costache is an assistant professor of ethnomusicology, and, by courtesy, Anthropology, at Stanford University. She is also an affiliate of the Center for Comparative Studies in Race and Ethnicity.
Her work explores the legacies of Romani historical trauma, and the feminist critiques of the present, inscribed in Romani music, sound, and art. Her writing has been published in EuropeNow, RevistaARTA, Critical Romani Studies, and is forthcoming in European History Quarterly. Her research has been supported by two Fulbright Grants and the Council of European Studies. She has held visiting and postdoctoral fellowships at the University of Pennsylvania, the United States Holocaust Memorial Museum, and the USC Shoah Foundation.
Her book project, Hearing Romani-ness, examines how music structures the political and social belonging of Romani peoples in ways that reify and work against processes of identity formation and racialization. Through an ethnographic focus on Romani musicians, the project shows how intergenerational memory of Romani trauma is discreetly imbedded in sonic expressions of sorrow within a bounded repertoire that in being kept private served as a vehicle for Romani collective healing. The book puts forth a new framework for navigating how sound, when heard as affective expression, can be used for reparative purposes in the wake of persecution, while also offering an interpretive and analytic vocabulary for learning to listen for the Roma.
