Stanford University
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Paul George, MD, PhD
Associate Professor of Neurology and Neurological Sciences (Adult Neurology) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsDEVELOPMENT OF STROKE RECOVERY THERAPEUTICS:
Stroke is devastating to patients and their caregivers. We currently are investigating 3 neural repair approaches. The first focuses on developing a stroke recovery therapeutic based on an essential repair pathway and how it alters the immune response following stroke. The second utilizes implantable, conductive polymer devices to electrically manipulate the recovering nervous system to improve recovery and identify novel therapeutic targets. The final approach works to optimize stem cell therapeutics to enhance their ability to treat patients who have suffered from neural injury.
CONDUCTIVE BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration. Recent work utilizes these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes. -
Marios Georgiadis
Instructor, Radiology
BioMarios is an Instructor of Neuroimaging in the Department of Radiology.
His research focuses mainly on studying brain microstructure using cutting edge imaging (advanced X-ray, MRI, optical, and spatial biology approaches), with a particular focus on Alzheimer's disease hippocampi, neurodegeneration, and a special interest in myelin and iron.
He is also actively involved in projects related to imaging and modeling brain trauma, exosome signatures of neurodegeneration, and imaging the brain using advanced forms of electron and light microscopy.
His current research is being supported by NIH, the Alzheimer's Association, the American Society of Neuroradiology, the National Alzheimer's Coordinating Center (NACC), and the Stanford ADRC.
Marios is a mechanical engineer by training (School of Mechanical Engineering, National Technical University of Athens, Greece). His thesis "Closed-loop force control of a haptic surgical simulator", was performed in the Control Systems Lab of Prof. Evangelos Papadopoulos.
In 2011 he obtained his MSc in Biomedical Engineering from ETH Zurich (Swiss Federal Institute of Technology). He performed his thesis in IBM Research on "Advanced pathology using the Microfluidic Probe", under Emmanuel Delamarche and Govind Kaigala, and was awarded the ETH medal for this work.
He completed his PhD in Bone Biomechanics in the lab of Prof. Ralph Muller in ETH Zurich, where he developed X-ray scattering-based methods to investigate bone microstructure in 3D, research that earned him the 2nd Student Award from the European Society for Biomechanics in 2015.
In 2016 he started using imaging methods to study brain microstructure, in the lab of Prof. Markus Rudin, in the Institute for Biomedical Engineering of ETH Zurich. There, he combined X-ray scattering with DTI, histology and CLARITY for studying rodent brain.
In 2017 he joined the MRI Biophysics group of Profs. Els Fieremans and Dmitry Novikov in New York University School of Medicine, to study human and mouse brain microstructure using X-ray scattering and diffusion MRI.
He is in the Translational Neuroimaging lab, headed by Dr Michael Zeineh, since 2019.
His research on myelin in mouse and human brain using X-ray scattering has been supported twice by the Swiss National Science Foundation. -
Daniel Aaron Gerber, MD
Clinical Associate Professor, Medicine - Cardiovascular Medicine
BioDr. Gerber is a critical care cardiologist and medical director of Stanford's cardiac ICU. He has dual subspecialty training in cardiovascular and critical care medicine and additional board certification in echocardiography. He completed his residency in internal medicine, fellowship in cardiovascular medicine, and an additional fellowship in critical care medicine at Stanford University and joined as faculty in 2021 as a Clinical Assistant Professor in the Department of Medicine’s Division of Cardiovascular Medicine.
Dr. Gerber manages the full spectrum of heart and vascular conditions with a focus on critically ill patients with life-threatening cardiovascular disease. He is active in medical education, teaching introductory echocardiography to Stanford medical students and residents, co-directing the Stanford Critical Care Medicine Critical Care Ultrasound Program, and lecturing nationally on critical care echocardiography and point-of-care ultrasonography at the Society of Critical Care Medicine’s annual congress. Finally, Dr. Gerber’s research interests focus on optimizing cardiac intensive care, including working with the Critical Care Cardiology Trials Network (CCCTN) - a national network of tertiary cardiac ICUs coordinated by the TIMI Study Group - and studying acute mechanical circulatory support techniques to improve patient outcomes and care processes.
