Stanford University
Showing 4,481-4,490 of 36,322 Results
-
Katie Cederberg
Postdoctoral Scholar, Psychiatry
BioDr. Cederberg is a postdoctoral scholar at Stanford University in the Mignot Lab, where she devotes her time to conducting research leveraging large datasets and machine learning approaches aimed at better understanding the relationship among genetics, proteomics and the presence and severity of symptoms related to sleep disorders. Her research further focuses on studying the effectiveness of exercise for managing symptoms of sleep disorders, primarily restless legs syndrome (RLS) and co-occurring conditions (e.g., periodic limb movements and insomnia). Her current research explores patients’ experiences with exercise and RLS, as well as the relationship between exercise and proteomic biomarkers of RLS. She received her PhD in Rehabilitation Science from the University of Alabama at Birmingham, and her dissertation used a series of methodological approaches to comprehensively examine the relationship between physical activity and RLS in adults who have multiple sclerosis. She is using her experience and training to develop a line of research for identifying the mechanism of action for the effect of exercise and informing exercise prescription parameters for managing symptoms of RLS.
-
Lynette Cegelski
Monroe E. Spaght Professor of Chemistry and Professor, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsResearch in the Cegelski laboratory is driven by the need to uncover and define the chemistry that underlies outstanding challenges in human health, the environment, and sustainability. Beyond discovery, we use chemistry as a tool to innovate and create solutions to these pressing problems. The laboratory is highly interdisciplinary, designing experimental approaches to understand how complex biological systems are built, organized, and controlled, and then perturb and influence assembly processes. The lab develops new methods and uniquely leverages: (1) small molecules in new biochemical assay development, chemical genetics approaches, and therapeutic discovery in infectious diseases, (2) fluorescence and electron microscopy coupled to analytical HPLC, mass spectrometry, and complementary biochemical techniques, and (3) spectroscopy, particularly solid-state NMR, to uncover new “dark matter” and define chemistry in insoluble, heterogeneous and complex assemblies relevant to human health, plants, and the ocean.
Long-standing efforts in the laboratory focus on defining mechanisms underlying bacterial biofilm formation and identifying new antibiotic and anti-virulence strategies, including advancing therapeutic candidates for the most difficult-to-treat infections. Through these efforts, we uncovered a new chemical structure in nature: phosphoethanolamine (pEtN) cellulose. Cellulose is the most abundant biopolymer on earth and this discovery provided the first experimental validation of a naturally produced chemically modified cellulose. We are developing alternatively modified celluloses and polysaccharides and advancing new solutions for ecofriendly, sustainably sourced, and recyclable materials. Collectively, our projects span disciplines from molecular structure and assembly chemistry to living microbial communities and natural marine systems, while aiming to translate fundamental discoveries into therapeutic and materials solutions.
