Stanford University
Showing 161-170 of 837 Results
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Maria Barna
Associate Professor of Genetics
Current Research and Scholarly InterestsOur lab studies how intricate control of gene expression and cell signaling is regulated on a minute-by-minute basis to give rise to the remarkable diversity of cell types and tissue morphology that form the living blueprints of developing organisms. Work in the Barna lab is presently split into two main research efforts. The first is investigating ribosome-mediated control of gene expression genome-wide in space and time during cellular differentiation and organismal development. This research is opening a new field of study in which we apply sophisticated mass spectrometry, computational biology, genomics, and developmental genetics, to characterize a ribosome code to gene expression. Our research has shown that not all of the millions of ribosomes within a cell are the same and that ribosome heterogeneity can diversify how genomes are translated into proteomes. In particular, we seek to address whether fundamental aspects of gene regulation are controlled by ribosomes harboring a unique activity or composition that are tuned to translating specific transcripts by virtue of RNA regulatory elements embedded within their 5’UTRs. The second research effort is centered on employing state-of-the-art live cell imaging to visualize cell signaling and cellular control of organogenesis. This research has led to the realization of a novel means of cell-cell communication dependent on a dense network of actin-based cellular extension within developing organs that interconnect and facilitate the precise transmission of molecular information between cells. We apply and create bioengineering tools to manipulate such cellular interactions and signaling in-vivo.
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Christopher O. Barnes
Assistant Professor of Biology and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsResearch in our lab is aimed at defining the structural correlates of broad and potent antibody-mediated neutralization of viruses. We combine biophysical and structural methods (e.g., cryo-EM), protein engineering, and in vivo approaches to understand how enveloped viruses infect host cells and elicit antigen-specific immune responses. We are particularly interested in the co-evolution of HIV-1 and broadly-neutralizing IgG antibodies (bNAbs), which may hold the key to the development of an effective HIV-1 vaccine. In addition, we are investigating antibody responses to SARS-CoV-2 and related zoonotic coronaviruses (CoV), with the related goal of developing broadly-protective immunotherapies and vaccines against variants of concern and emerging CoV threats.
HIV-1; SARS-CoV-2; coronaviruses; cryo-EM; crystallography; vaccines; directed evolution -
Leandra A. Barnes, MD
Instructor, Dermatology
BioDr. Barnes is a board-certified dermatologist who provides care at Stanford Health Care Dermatology Clinics in Redwood City and Emeryville. She is also an Instructor of Dermatology within the Department of Dermatology at Stanford School of Medicine.
Dr. Barnes specializes in diagnosing and treating a broad range of skin conditions, including hidradenitis suppurativa, skin cancer, and conditions that disproportionally impact people of color. As Co-Director of the Stanford Medicine Hidradenitis Suppurativa Specialty Clinic, her clinical focus includes maximizing awareness of and care options for this condition. Dr. Barnes is also the Founding Director of the Stanford Medicine Skin of Color Program and Director of Advocacy, Equity, and Inclusion in the Department of Dermatology at Stanford Medicine.
Dr. Barnes’ clinical research focuses on identifying the underlying mechanisms associated with the onset and progression of hidradenitis suppurativa. These efforts include research on access to care among different patient populations and studies identifying immune-mediated characteristics of the condition. She is also engaged in efforts to promote broader and more effective outreach initiatives to drive melanoma awareness among minority populations and young children.
Dr. Barnes has published her work in numerous peer-reviewed journals, including the Journal of Investigative Dermatology, JAMA Dermatology, and the Journal of the American Academy of Dermatology. She has also been an invited guest speaker at national and international meetings, including those for the Society of Investigative Dermatology and the World Congress of Dermatology. -
Patrick Barnes
Professor of Radiology (Pediatric Radiology) at the Stanford University Medical Center, Emeritus
Current Research and Scholarly InterestsAdvanced imaging, including magnetic resonance imaging, of injury to the developing central nervous system; including fetal, neonatal, infant and young child; and, including nonaccidental injury (e.g. child abuse).
See Biosketch for details.
