Stanford University
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Aubrey Hargrave
Temp - Non-Exempt, Ophthalmology Research/Clinical Trials
BioMy research interests are centered on ocular immunology and neuroinflammation. My long-standing interest in eye research stems from personal experience with eye disease, which has led me to explore vision research and underlies my passion for disease-centric research in order to improve quality of life for patients.
I am fascinated by the immune response and inflammation, in part because of its broad applicability to many human diseases. To this end, I am interested in developing an understanding of the interplay between the immune and nervous systems in the ocular microenvironment and my past research has allowed me to explore this interplay within diverse areas of the eye. As an undergraduate, I conducted research with Dr. Rima Mcleod to study patients with toxoplasmosis, a disease affecting both ocular and neural tissue. We created a patient database and investigated whether genotype influences the inflammatory response to the t.gondii parasite. As a predoctoral student with Dr. Alan Burns, my research focused on ocular inflammation in two cases; first, in acute inflammation following a corneal abrasion and second, in the context of systemic inflammation caused by early metabolic syndrome. I analyzed the immune response in both cases and developed methods to determine the effect on corneal nerves.
During my postdoctoral training with Dr. Alfredo Dubra, I am continuing to build on my previous training in vision science, inflammation, and neurodegeneration by using adaptive optics imaging, in conjunction with standard clinical measurements, to explore potential biomarkers in diseases such as multiple sclerosis, glaucoma, and retinal degeneration. With high-resolution in vivo adaptive optics imaging we are able to monitor changes in retinal tissues at the cellular level over time, as well as to observe minute changes in the retina with treatment during clinical trials. -
Brian A. Hargreaves
Professor of Radiology (Radiological Sciences Laboratory) and, by courtesy, of Electrical Engineering and of Bioengineering
Current Research and Scholarly InterestsI am interested in magnetic resonance imaging (MRI) applications and augmented reality applications in medicine. These include abdominal, breast and musculoskeletal imaging, which require development of faster, quantitative, and more efficient MRI methods that provide improved diagnostic contrast compared with current methods. My work includes novel excitation schemes, efficient imaging methods and reconstruction tools and augmented reality in medicine.
