Stanford University
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Sydney X. Lu
Assistant Professor of Medicine (Hematology)
BioSydney Lu is a hematologist and medical oncologist in the Division of Hematology, Department of Medicine, studying novel therapeutics for challenging cancers and immune disorders.
Sydney's research career started with graduate studies in the laboratory of Dr. Marcel van den Brink at Memorial Sloan Kettering Cancer Center (MSKCC) studying the biology of pathologic donor T cells during graft-versus-host-disease and beneficial T cells mediating graft-versus-tumor effects after allogeneic bone marrow transplant, as well as the role of the thymus in regenerating healthy and protective donor-derived T cells post-transplant.
The direct relevance of these cellular therapies and their immediate translational applicability to patients inspired him to attend medical school at Stanford and further training in hematology and medical oncology at Memorial Sloan Kettering. There, as a fellow and junior faculty member, he studied disordered RNA splicing in cancer in the laboratory of Dr. Omar Abdel-Wahab, with the goal of developing novel drugs targeting RNA splicing. This work has led to observations that targeted degradation of the RNA binding protein RBM39 may be a feasible therapeutic for the treatment of myeloid cancers bearing RNA splicing factor mutations and that pharmacologic RNA splicing inhibition can generate MHC I-presented peptide neoantigens which are exploitable for immunotherapy in model systems.
Sydney's laboratory is broadly interested in studying RNA processing and splicing in the contexts of:
1) normal and pathologic immunity and immunotherapy
2) cancer biology
3) normal and malignant hematopoiesis -
Wan-Jin Lu
Basic Life Research Scientist, Stem Cell Bio Regenerative Med Institute
BioDr. Wan-Jin Lu is a Research Scientist in Dr. Phil Beachy's lab. Wan-Jin grew up in Taiwan, obtained her B.S. in Zoology at National Taiwan University and completed her PhD in Genetics and Development at UT Southwestern in the lab of Dr. John Abrams. Her Ph.D. research involved the identification of the evolutionary conserved function of the tumor suppressor gene p53 that ensures the quality control of germ cells. She then moved to the Bay Area, where she was a Damon Runyon Postdoctoral Fellow in the Institute of Stem Cell Biology and Regenerative Medicine in the Beachy lab. Her work currently focuses on understanding the function of Hedgehog signaling in taste receptor cell homeostasis and delineating the mechanisms of taste receptor regeneration after chemotherapy-induced loss.
Since 2017, she has been collaborating with Tabula Muris And Tabula Sapiens Consortium to investigate taste receptor stem cell renewal and regeneration in the Beachy lab. Her work has received funding support from California Institute of Regenerative Medicine (CIRM), Thomas and Stacey Siebel Foundation, and NIH (R21 and R01).
