Stanford University
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Pavan Yadav
Postdoctoral Scholar, Chemistry
BioI am a Postdoctoral Researcher at Stanford University in the laboratory of Professor Paul A. Wender, where I work on the development of delivery technologies for RNA therapeutics, including mRNA, circular RNA (circRNA), and oligonucleotide-based medicines. My current research focuses on lipid nanoparticles (LNPs) and transporter-based systems for targeted nucleic acid delivery, with the goal of advancing the translation of genetic medicines.
I received my Ph.D. in Pharmaceutical Sciences from CSIR–Central Drug Research Institute (CSIR-CDRI), India. During my doctoral training, I specialized in nanomedicine, drug delivery, pharmacokinetics, and bioanalytical method development, with a particular focus on developing nanocarrier-based therapeutic strategies for cancer treatment. Prior to my Ph.D., I earned both my Bachelor of Pharmacy and Master of Pharmacy degrees from Mahatma Jyotiba Phule Rohilkhand University, India.
My research interests span RNA therapeutics, drug delivery, nanomedicine, lipid nanoparticle engineering, pharmacokinetics, and translational pharmaceutical sciences. I have experience in the design, formulation, and biological evaluation of diverse delivery systems, including lipid nanoparticles, liposomes, nanoemulsions, polymeric carriers, and other nanomaterial-based therapeutic platforms. My work integrates formulation science, biological evaluation, and preclinical studies to improve the delivery and performance of therapeutic agents.
I have authored more than 35 peer-reviewed publications in journals such as Nature Communications, ACS Applied Materials & Interfaces, International Journal of Pharmaceutics, Nanomedicine, and Bioanalysis. I am particularly interested in developing innovative delivery approaches that bridge fundamental research and clinical translation, with the ultimate goal of improving treatment options for patients. -
Richard Zare
Marguerite Blake Wilbur Professor of Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly InterestsMy research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells. -
Xingyuan Zhang
Ph.D. Student in Chemistry, admitted Autumn 2023
Ph.D. Minor, Computer ScienceBioPhD candidate in Chemistry and Computer Science, Wu Tsai Neurosciences and Sarafan ChEM-H Institute at Stanford University. Working on scientific machine learning, biomolecular modeling, and protein design for drug discovery and disease modeling.
