Stanford University
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Karen G. Hirsch, MD
Professor of Neurology and Neurological Sciences (Adult Neurology)
Current Research and Scholarly InterestsDr. Karen G. Hirsch cares for critically ill patients with neurologic disorders in the intensive care unit. Dr. Hirsch's research focuses on using continuous and discrete multi-modal data to develop phenotypes and identify signatures of treatment responsiveness in patients with coma after cardiac arrest. She is the Co-PI of PRECICECAP (PRecision Care In Cardiac ArrEst - ICECAP, NINDS R01 NS119825-01). The research team works closely with collaborators in data science at Stanford and with industry partners to apply machine learning analyses to complex multi-modal ICU data. Dr. Hirsch also studies neuro-imaging in post-cardiac arrest coma and traumatic brain injury, and with colleagues in Cardiac Anesthesia and Cardiothoracic Surgery, Dr. Hirsch studies neurologic outcomes in patients on mechanical circulatory support including ECMO.
Along with colleagues in Biomedical Ethics, Dr. Hirsch studies brain death, organ donation, and neuroethics. She is the Co-PI of BCI-DEF (Brain Computer Interfaces and Disability: Developing an Inclusive Ethical Framework, NIMH 1R01MH130518-01) which is a BRAIN Initiative funded study that is qualitatively evaluating end user perspectives about the benefits, risks, and ethical challenges of Brain Computer Interfaces for patients with acute stroke or traumatic brain injury.
Dr. Hirsch is broadly interested in improving neurologic outcomes after acute severe brain injury, identifying early phenotypes to guide precision medicine in neurocritical care, and exploring ethical issues in neurocritical care and novel neurotechnology. Dr. Hirsch greatly appreciates the importance of team science and collaboration. -
Frances Hisgen
Juris Doctor Student, Law
BioFrances Hisgen is the senior research program manager for the program on the US, China, and the World at the Hoover Institution, where she also serves as key personnel for the National Science Foundation’s SECURE program, a $67 million effort authorized by the CHIPS and Science Act of 2022 to enhance the security and integrity of the US research enterprise. Prior to joining Hoover, she worked at the American Chamber of Commerce (Hong Kong), at Caixin (Beijing), and at ChinaFile at the Asia Society's Center for US-China Relations. Hisgen earned an MPhil in World History at the University of Cambridge (UK), where she was the Paul Williams Fellow at Emmanuel College, and received her AB in History from Harvard College. Her academic work on the movement of people, ideas, and commodities spurred by European and American imperialism in greater China in the 18th through 20th centuries has been presented at the Cambridge World History Workshop, the Women's History Network Conference, and been supported by the Radcliffe Institute for Advanced Study and the Weatherhead Center for International Affairs. In addition to her work at Hoover, she is a Foreign Policy for America Next Generation Fellow in the 2024 cohort, as well as a 2024 New Voice in New America's Out in National Security initiative.