Stanford University
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Gheorghe Chistol
Assistant Professor of Chemical and Systems Biology
Current Research and Scholarly InterestsResearch in my laboratory is aimed at understanding how eukaryotes replicate their DNA despite numerous challenges (collectively known as replication stress), and more generally – how eukaryotic cells safeguard genome integrity. Specifically, we are investigating: (i) mechanisms that regulate the activity of the replicative helicase during replication stress, (ii) mechanisms that control the inheritance of epigenetic information during replication, and (iii) mechanisms of ubiquitin-mediated regulation of genome maintenance. We utilize single-molecule microscopy to directly image fluorescently-labeled replication factors and track them in real time in Xenopus egg extracts. I developed this system as a postdoctoral fellow, and used it to monitor how the eukaryotic replicative helicase copes with DNA damage. We plan to further extend the capabilities of this platform to directly visualize other essential replication factors, nucleosomes, and regulatory post-translational modifications like ubiquitin chains. By elucidating molecular mechanisms responsible for maintaining genome stability, we aim to better understand the link between genome instability and cancer, and how these mechanisms can be harnessed to improve disease treatment.
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Ani Chiti
Postdoctoral Scholar, Physics
BioI am a Brinson Prize Fellow at Stanford University, primarily interested in the formation of the first stars and galaxies, the formation of heavy elements, the early Milky Way, and local dynamical tracers of dark matter. I observe and characterize nearby stars and galaxies that formed at early times to understand these topics, in an approach known as "Near-field cosmology" or "Galactic archaeology".
Before joining Stanford, I was the inaugural Brinson Prize Fellow in Observational Astrophysics at the University of Chicago. I obtained a PhD in Physics from MIT in 2021, and received bachelor's degrees in Physics and Mathematics from Cornell University in 2014.
